Production Method 1

923023-07-8

923023-08-9

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  150 °C

Reference

Preparation of cyclohexylamine substituted isoquinolones as Rho-kinase inhibitors

, World Intellectual Property Organization, , ,

trans-4-Methylamino-cyclohexanol hydrochloride Raw materials

• Acetamide, 2,2,2-trifluoro-N-(trans-4-hydroxycyclohexyl)-N-methyl-

trans-4-Methylamino-cyclohexanol hydrochloride Preparation Products

• trans-4-Methylamino-cyclohexanol hydrochloride (923023-08-9)

• 1. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
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Professional Introduction to trans-4-Methylamino-cyclohexanol hydrochloride (CAS No. 923023-08-9)

trans-4-Methylamino-cyclohexanol hydrochloride, identified by its CAS number 923023-08-9, is a compound of significant interest in the field of pharmaceutical chemistry and drug development. This compound, a hydrochloride salt, has garnered attention due to its structural properties and potential applications in medicinal chemistry. The unique configuration of the trans-4-methylamino group on the cyclohexanol backbone contributes to its distinct pharmacological profile, making it a valuable candidate for further investigation.

The chemical structure of trans-4-Methylamino-cyclohexanol hydrochloride consists of a cyclohexane ring substituted with an amino group at the 4-position and a methyl group adjacent to it. This arrangement imparts specific steric and electronic properties that influence its interactions with biological targets. The hydrochloride form enhances the compound's solubility in aqueous solutions, facilitating its use in various pharmaceutical formulations and experimental protocols.

In recent years, there has been growing interest in exploring the pharmacological potential of compounds with similar structural motifs. The presence of the amino group and the cyclohexane ring suggests possible applications in the development of central nervous system (CNS) therapeutics, given the importance of these structural elements in modulating neurotransmitter activity. Preclinical studies have begun to uncover promising leads in this area, indicating that trans-4-Methylamino-cyclohexanol hydrochloride may exhibit properties relevant to treatments for neurological disorders.

One of the most compelling aspects of this compound is its potential as a precursor or analog in drug design. The flexibility of the cyclohexane ring allows for modifications that can fine-tune pharmacokinetic and pharmacodynamic properties. Researchers are particularly interested in how variations around the methylamino group can influence binding affinity and selectivity for specific receptors or enzymes. This has led to several synthetic strategies aimed at optimizing the scaffold for improved therapeutic efficacy.

The hydrochloride salt form of trans-4-Methylamino-cyclohexanol hydrochloride also offers advantages in terms of stability and handling. Hydrochlorides are commonly used in pharmaceuticals due to their well-established compatibility with various excipients and their ability to provide a stable crystalline form. This makes them ideal for formulation into tablets, capsules, and other dosage forms, ensuring consistent delivery to patients.

Recent advancements in computational chemistry have enabled more sophisticated modeling of molecular interactions, which has been instrumental in guiding the development of derivatives of trans-4-Methylamino-cyclohexanol hydrochloride. By leveraging machine learning algorithms and molecular dynamics simulations, researchers can predict how structural modifications will affect biological activity. This approach has accelerated the discovery process, allowing for rapid screening of potential candidates with optimized properties.

In addition to its potential applications in CNS disorders, trans-4-Methylamino-cyclohexanol hydrochloride has shown promise in other therapeutic areas. Its structural features make it a viable candidate for exploring interactions with enzymes involved in metabolic pathways, such as those relevant to inflammation and pain management. Preliminary data suggest that derivatives of this compound may exhibit anti-inflammatory effects by modulating key signaling pathways.

The synthesis of trans-4-Methylamino-cyclohexanol hydrochloride involves multi-step organic reactions that require precise control over reaction conditions. Advances in synthetic methodologies have made it possible to produce this compound with high yield and purity, ensuring its suitability for both research and commercial applications. Techniques such as catalytic hydrogenation and asymmetric synthesis have been particularly useful in constructing the desired stereoisomer.

The growing body of research on trans-4-Methylamino-cyclohexanol hydrochloride underscores its importance as a building block in medicinal chemistry. Its unique structural features offer opportunities for innovation across multiple therapeutic domains. As more data becomes available from preclinical studies, it is likely that this compound will continue to attract attention from academic researchers and pharmaceutical companies alike.

In conclusion, trans-4-Methylamino-cyclohexanol hydrochloride (CAS No. 923023-08-9) represents a significant advancement in pharmaceutical research. Its structural characteristics, combined with its potential applications, make it a compelling subject for further investigation. As scientific understanding progresses, this compound is poised to play a crucial role in the development of novel therapeutics aimed at addressing unmet medical needs.

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