Production Method 1

867-13-0

6704-31-0

922500-91-2

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  0 °C; 30 min, rt
1.2 overnight, rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Synthesis of All-Carbon Quaternary Centers by Palladium-Catalyzed Olefin Dicarbofunctionalization

Koy, Maximilian ; Bellotti, Peter ; Katzenburg, Felix; Daniliuc, Constantin G. ; Glorius, Frank, Angewandte Chemie, 2020, 59(6), 2375-2379

Production Method 2

6704-31-0

922500-91-2

Reaction Conditions

Reference

Selective preparation of tetrasubstituted fluoroalkenes by fluorine-directed oxetane ring-opening reactions

Fontenelle, Clement Q. ; Thierry, Thibault ; Laporte, Romain ; Pfund, Emmanuel ; Lequeux, Thierry, Beilstein Journal of Organic Chemistry, 2020, 16, 1936-1946

Production Method 3

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane

Reference

3-Oxetanone

Banerjee, Abhisek, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2014, 1, 1-6

Production Method 4

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  0.5 h, rt

Reference

Preparation of imidazo[4,5-c]quinoline derivatives that are kinase inhibitors inhibitors useful in treatment of proliferative , neoplastic and other kinase-mediated diseases

, World Intellectual Property Organization, , ,

Production Method 5

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  0 °C; 2 h, 0 °C → rt

Reference

GPR40 receptor agonist, and its preparing method, pharmaceutical composition and application

, China, , ,

Production Method 6

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  cooled; 2 h, rt

Reference

Preparation of tetrahydrothienopyrimidinesulfonamide compounds as poly(ADPribose)glycohydrolase (PARG) inhibitors and anticancer agents

, World Intellectual Property Organization, , ,

Production Method 7

867-13-0

6704-31-0

922500-91-2

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide ,  Sodium hydride Solvents: Tetrahydrofuran ;  0 - 5 °C; 30 min, 0 - 5 °C
1.2 0 - 5 °C; 17 h, 0 - 5 °C

Reference

Preparation of 3-(substituted phenyl) oxetane-3-carboxylic acid and intermediates

, China, , ,

Production Method 8

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  0 °C; 0 °C → rt; 15 min, rt

Reference

Preparation of [1H-pyrazolo[3,4-b]pyridin-4-yl]phenyl or pyridin-2-yl derivatives as protein kinase C-theta inhibitors

, World Intellectual Property Organization, , ,

Production Method 9

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  cooled; overnight, rt

Reference

Preparation of the novel spirocyclic k-ras g12c inhibitor

, China, , ,

Production Method 10

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  1 h, < 10 °C; < 10 °C → rt; 1.5 h, rt

Reference

Imidazoles as Nav1.8 inhibitors and their preparation and use in the treatment of pain

, World Intellectual Property Organization, , ,

Production Method 11

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane

Reference

Oxetanes in Drug Discovery: Structural and Synthetic Insights

Wuitschik, Georg; Carreira, Erick M.; Wagner, Bjorn; Fischer, Holger; Parrilla, Isabelle; et al, Journal of Medicinal Chemistry, 2010, 53(8), 3227-3246

Production Method 12

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  0 °C; 30 min, rt

Reference

Concise synthesis and characterization of novel seco-steroids bearing a spiro-oxetane instead of a metabolically labile C3-hydroxy group

Fujishima, Toshie; Suenaga, Tsutomu; Nozaki, Takato, Tetrahedron Letters, 2014, 55(28), 3805-3808

Production Method 13

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  rt

Reference

Preparation of arylalkylamine compound as CaSR agonist and used for treatment or prevention of diseases or disorders mediated by CaSR activity

, China, , ,

Production Method 14

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  rt

Reference

(Ethoxycarbonylmethylene)triphenylphosphorane

Reitz, Allen B.; McDonnell, Mark E.; Nikonov, George, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2012, 1, 1-9

Production Method 15

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  0 °C; 15 min, 0 °C → rt

Reference

Oxetanes as promising modules in drug discovery

Wuitschik, Georg; Rogers-Evans, Mark; Mueller, Klaus; Fischer, Holger; Wagner, Bjoern; et al, Angewandte Chemie, 2006, 45(46), 7736-7739

Production Method 16

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  0 °C; 1 h, rt
1.2 30 min, rt

Reference

Preparation of bicyclo[3.2.0]heptane derivatives for treatment of pain

, World Intellectual Property Organization, , ,

Production Method 17

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  0 °C; 3 h, 0 °C

Reference

Preparation method for bicyclic compound and application as antifungal agent

, World Intellectual Property Organization, , ,

Production Method 18

3699-66-9

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  0 °C → rt; 2 h, rt

Reference

Preparation of aromatic urea derivatives as IDO inhibitors

, World Intellectual Property Organization, , ,

Production Method 19

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  0 °C; 0 °C → rt; 15 min, rt

Reference

Preparation of nitrogen heterocyclic compounds useful as 3',5'-cyclic nucleotide-specific phosphodiesterase 10 (PDE10) inhibitors

, World Intellectual Property Organization, , ,

Production Method 20

1099-45-2

6704-31-0

922500-91-2

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  0 °C; overnight, rt

Reference

Design and Identification of a GPR40 Full Agonist (SCO-267) Possessing a 2-Carbamoylphenyl Piperidine Moiety

Furukawa, Hideki ; Miyamoto, Yasufumi; Hirata, Yasuhiro; Watanabe, Koji; Hitomi, Yuko; et al, Journal of Medicinal Chemistry, 2020, 63(18), 10352-10379

Ethyl 2-(oxetan-3-ylidene)acetate Raw materials

• Triethyl phosphonoacetate
• ethyl 2-diethoxyphosphorylpropanoate
• ethyl 2-(triphenyl-λ?-phosphanylidene)acetate
• 3-Oxetanone

Ethyl 2-(oxetan-3-ylidene)acetate Preparation Products

• Ethyl 2-(oxetan-3-ylidene)acetate (922500-91-2)

• 1. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 2. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 3. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 4. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 5. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid esters
• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid derivatives Carboxylic acid esters

• 34876-10-3(2-Butenoic acid,3-methyl-, 1,1'-anhydride)
• 51552-26-2(2-Butenoic acid, 3-methyl-, 2-propenyl ester)
• 6124-79-4(4-Methyl-2(5H)-furanone)
• 638-10-8(ethyl 3-methylbut-2-enoate)
• 62285-74-9(2-Butenal, 4-(acetyloxy)-3-methyl-, (E)-)
• 65594-81-2(2-Butenal, 4-(acetyloxy)-3-methyl-)
• 41891-38-7(2-Butenoic acid,3-methyl-4-oxo-, ethyl ester)
• 27819-09-6(2-Butenoic acid,2-methyl-2-propen-1-yl ester)
• 62054-50-6(2-Butenoic acid, 3-methyl-4-oxo-, ethyl ester, (Z)-)
• 72779-06-7(2-Butenoic acid,3-methyl-, 3-methyl-2-buten-1-yl ester)