Production Method 1

24424-99-5

3184-13-2

92235-39-7

Reaction Conditions

1.1 Reagents: Chlorotrimethylsilane Solvents: Methanol ;  overnight, reflux; reflux → 0 °C
1.2 Reagents: Sodium carbonate Solvents: Methanol ;  3.5 h, rt
1.3 10 min, rt

Reference

Preparation of optically-active octahydropyrrolo[3,2-b]pyridin-2-one derivatives and their intermediates

, Japan, , ,

Production Method 2

24424-99-5

3184-13-2

92235-39-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  15 min, 25 °C
1.2 Reagents: Alumina Solvents: Toluene ;  3 h, reflux
1.3 Reagents: Triethylamine Solvents: 1,4-Dioxane ,  Water ;  24 h, 0 °C → rt
1.4 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

First Multigram Scale-Up and Synthesis of Novel Valerolactam- Benzimidazole Hybrid Anthelmintic

Colobbio, Maximiliano ; Duarte, Gerardo; Melian, Maria Elisa; Silvera, Mauricio; Teixeira, Ramiro; et al, Letters in Drug Design & Discovery, 2023, 20(2), 225-231

Production Method 3

2480-95-7

92235-39-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Acetic acid ,  Methanol
1.2 Reagents: Sodium carbonate Solvents: Dimethylformamide

Reference

Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2

Yu, Kuo Long; Rajakumar, G.; Srivastava, Lalit K.; Mishra, Ram K.; Johnson, Rodney L., Journal of Medicinal Chemistry, 1988, 31(7), 1430-6

Production Method 4

92235-39-7

Reaction Conditions

1.1 Reagents: 4-Methylmorpholine ,  Potassium hydroxide ,  Triphosgene Solvents: Acetonitrile ,  Water ;  20 °C
1.2 Reagents: Ammonium chloride Solvents: Water ;  15 s, 20 °C

Reference

Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Microflow Reactor

Fuse, Shinichiro ; Komuro, Keiji ; Otake, Yuma ; Masui, Hisashi ; Nakamura, Hiroyuki, Chemistry - A European Journal, 2021, 27(27), 7525-7532

Production Method 5

24424-99-5

3184-13-2

92235-39-7

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ;  45 min, rt; 4 h, rt
1.2 Reagents: Sodium methoxide Solvents: Methanol ;  4 h, rt
1.3 Reagents: Triethylamine Solvents: Dichloromethane ;  60 h, 20 - 25 °C

Reference

Preparation of heterocyclic substituted aminoazacycles useful as central nervous system agents

, World Intellectual Property Organization, , ,

Production Method 6

1071421-70-9

92235-39-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium (carbon-supported) Solvents: Methanol ;  15 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Ethyl acetate ;  3 d, rt

Reference

Asymmetric synthesis of (3S,9S)-ciliatamide C

, China, , ,

Production Method 7

21887-64-9

92235-39-7

Reaction Conditions

1.1 Reagents: Sodium bicarbonate ,  BOP reagent Solvents: Dimethylformamide ;  12 h, rt

Reference

Ribosome-mediated incorporation of peptides and peptidomimetics during cell-free translation

, World Intellectual Property Organization, , ,

Production Method 8

78397-39-4

92235-39-7

Reaction Conditions

Reference

Studies directed toward the synthesis of naturally occurring acyltetramic acids. 2. Preparation of the macrocyclic subunit of ikarugamycin

Boeckman, Robert K. Jr.; Perni, Robert B., Journal of Organic Chemistry, 1986, 51(26), 5486-9

Production Method 9

21887-64-9

92235-39-7

Reaction Conditions

1.1 Reagents: Diphenylsilane ,  4-(Dimethylamino)pyridine ,  Diisopropylethylamine Solvents: Acetonitrile ;  42 h, 80 °C

Reference

Diphenylsilane as a coupling reagent for amide bond formation

Sayes, Morgane; Charette, Andre B., Green Chemistry, 2017, 19(21), 5060-5064

Production Method 10

21887-64-9

92235-39-7

Reaction Conditions

1.1 Reagents: Ethanol, 2,2,2-trifluoro-, 1,1′,1′′-triester with boric acid (H3BO3) Solvents: Acetonitrile ;  15 h, 80 °C

Reference

Direct Synthesis of Amides from Carboxylic Acids and Amines Using B(OCH2CF3)3

Lanigan, Rachel M.; Starkov, Pavel; Sheppard, Tom D., Journal of Organic Chemistry, 2013, 78(9), 4512-4523

Production Method 11

748150-93-8

92235-39-7

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Ethyl acetate

Reference

A flexible approach for the synthesis of selectively labelled L-arginine

Hamilton, Deborah J.; Sutherland, Andrew, Tetrahedron Letters, 2004, 45(29), 5739-5741

Production Method 12

24424-99-5

34294-79-6

92235-39-7

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  16 h, rt
1.2 Reagents: Diethyl ether ;  rt

Reference

Indazolecarboxamide derivatives as p38 inhibitors and their preparation and methods of use thereof

, World Intellectual Property Organization, , ,

Production Method 13

24424-99-5

40216-82-8

92235-39-7

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Methanol ;  4 h, reflux
1.2 Reagents: Ammonium chloride ;  overnight, rt
1.3 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran ,  Water ;  overnight, rt

Reference

Preparation and reactivity of aminoacyl pyroglutamates. Facile synthesis of 10-membered-ring cyclic dipeptides derived from 1,4-diaminobutyric and glutamic acids

Chulin, A. N.; Rodionov, I. L.; Baidakova, L. K.; Rodionova, L. N.; Balashova, T. A.; et al, Journal of Peptide Science, 2005, 11(3), 175-186

Production Method 14

70-26-8

24424-99-5

92235-39-7

Reaction Conditions

1.1 Reagents: Alumina Solvents: Toluene ;  reflux
1.2 -

Reference

Synthesis and Anthelmintic Evaluation of Novel Valerolactam-Benzimidazole Hybrids

Munguia, Beatriz; Mendina, Pablo; Espinosa, Romina; Lanz, Andrea; Saldana, Jenny; et al, Letters in Drug Design & Discovery, 2013, 10(10), 1007-1014

Production Method 15

24424-99-5

40216-82-8

92235-39-7

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ;  1 h, rt
1.2 Solvents: Methanol ;  18 h, rt

Reference

Preparation of heterocyclic amides, in particular azolanes and pyridines as Phosphodiesterase IV (PDE4) inhibitors for the treatment of inflammatory and allergic disorders

, World Intellectual Property Organization, , ,

N-Boc L-Orinithine Lactam Raw materials

• (2S)-2,5-diaminopentanoic acid
• Di-tert-butyl dicarbonate
• L-Norvaline, 5-azido-N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
• (s)-3-Aminopiperidin-2-one
• (S)-Methyl 5-amino-2-((tert-butoxycarbonyl)amino)pentanoate
• Nα-Boc-L-Ornithine
• H-Orn-OMe Dihydrochloride
• (S)-ornithine hydrochloride
• (S)-Methyl 5-amino-2-((tert-butoxycarbonyl)amino)pentanoate hydrochloride
• Boc-Orn(Cbz)-OMe

N-Boc L-Orinithine Lactam Preparation Products

• N-Boc L-Orinithine Lactam (92235-39-7)

• 1. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 2. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 3. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 4. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 5. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569

• 221874-51-7(tert-butyl N-(3R)-2-oxopiperidin-3-ylcarbamate)
• 76944-95-1(tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate)
• 99780-98-0(tert-butyl N-(2-oxopiperidin-3-yl)carbamate)
• 139178-66-8(Carbamic acid, [2-(methylamino)-2-oxo-1-(4-piperidinylmethyl)ethyl]-, 1,1-dimethylethyl ester, (R)- (9CI))
• 31140-42-8(tert-Butyl (2,6-Dioxopiperidin-3-yl)carbamate)
• 85574-35-2(Carbamicacid, [3-methyl-1-[(propylamino)carbonyl]butyl]-, 1,1-dimethylethyl ester, (S)-(9CI))
• 179686-45-4(tert-butyl N-(2-oxoazepan-3-yl)carbamate)
• 89226-19-7(Glycinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-)
• 139178-67-9(Carbamic acid, [2-(methylamino)-2-oxo-1-(4-piperidinylmethyl)ethyl]-,1,1-dimethylethyl ester, (S)-)
• 106691-72-9(tert-butyl N-[(3R)-2-oxoazepan-3-yl]carbamate)