Production Method 1

921-08-4

Reaction Conditions

1.1 Reagents: Lithium hydroxide ,  Hydrogen peroxide Solvents: Tetrahydrofuran ,  Water
1.2 Reagents: Sodium sulfite Solvents: Water

Reference

Process for hydrolysis of alpha-substituted alpha-chiral carboxylic acid esters

, France, , ,

Production Method 2

921-08-4

Reaction Conditions

Reference

Paired electrolysis-enabled nickel-catalyzed enantioselective reductive cross-coupling between α-chloroesters and aryl bromides

Liu, Dong; Liu, Zhao-Ran; Wang, Zhen-Hua; Ma, Cong; Herbert, Simon; et al, Nature Communications, 2022, 13(1),

Production Method 3

921-08-4

Reaction Conditions

Reference

Synthetic methods and reactions. Part 117. α-chlorocarboxylic acids from α-amino acids

Olah, George A.; Shih, Joseph; Prakash, G. K. Surya, Helvetica Chimica Acta, 1983, 66(4), 1028-30

Production Method 4

921-08-4

Reaction Conditions

Reference

α-Chlorination of carboxylic acids mediated by chlorosulfonic acid: ε-benzoylamino-α-chlorocaproic acid

Ogata, Yoshiro; Sugimoto, Toshiyuki; Inaishi, Morio, Organic Syntheses, 1980, 59, 20-6

Production Method 5

921-08-4

Reaction Conditions

Reference

New method for preparing α-chloro(bromo)carboxylic acids

Gendrikov, E. P.; Zhudina, V. I.; Bogatskii, A. V., Dopovidi Akademii Nauk Ukrains'koi RSR, 1978, (1), 33-5

Production Method 6

921-08-4

Reaction Conditions

Reference

α-Chloroisovaleric acid

, Japan, , ,

Production Method 7

1522-46-9

921-08-4

Reaction Conditions

1.1 Reagents: Sodium hypochlorite

Reference

Haloformic reaction. I. Some new possibilities for using a haloformic reaction

Gendrikov, E. P.; Zhudina, V. I.; Bogatskii, A. V.; Kolyankovskii, A. A.; Stepanova, O. S.; et al, Zhurnal Organicheskoi Khimii, 1978, 14(4), 725-9

Production Method 8

72-18-4

921-08-4

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water ;  -5 °C; < 5 °C; 5 h, -5 °C; -5 °C → rt; overnight, rt; 20 h, rt
1.2 Reagents: Sodium carbonate

Reference

A modular synthesis of teraryl-based α-helix mimetics, Part 1: Synthesis of core fragments with two electronically differentiated leaving groups

Peters, Martin; Trobe, Melanie; Tan, Hao; Kleineweischede, Rolf; Breinbauer, Rolf, Chemistry - A European Journal, 2013, 19(7), 2442-2449

Production Method 9

516-06-3

921-08-4

Reaction Conditions

Reference

Nickel-catalyzed asymmetric reductive cross-coupling of α-chloroesters with (hetero)aryl iodides

DeLano, Travis J.; Dibrell, Sara E.; Lacker, Caitlin R.; Pancoast, Adam R.; Poremba, Kelsey E.; et al, Chemical Science, 2021, 12(22), 7758-7762

Production Method 10

921-08-4

Reaction Conditions

Reference

The α-chlorination of isovaleric acid

Ogata, Yoshiro; Ikejiri, Toshinori, Nippon Kagaku Kaishi, 1975, (9), 1517-19

Production Method 11

921-08-4

Reaction Conditions

Reference

α-Chlorination of aliphatic acids by molecular chlorine

Ogata, Yoshiro; Harada, Taira; Matsuyama, Kazuo; Ikejiri, Toshinori, Journal of Organic Chemistry, 1975, 40(20), 2960-2

Production Method 12

921-08-4

Reaction Conditions

Reference

Stereospecific ring contractions of 7-chlorobicyclo[3.2.0]hept-2-en-6-ones and equilibration studies of 7-alkylbicyclo[3.2.0]hept-2-en-6-ones

Brook, Peter R.; Duke, A. Jonathan; Harrison, John M.; Hunt, Keith, Journal of the Chemical Society, 1974, (8), 927-32

2-Chloro-3-methylbutyric acid Raw materials

• DL-Valine
• Ethyl 2-Isopropylacetoacetate
• L-Valine

2-Chloro-3-methylbutyric acid Preparation Products

• 2-Chloro-3-methylbutyric acid (921-08-4)

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• 5. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330

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