Production Method 1

533-58-4

1004517-48-9

920981-12-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ;  10 min, 5 °C
1.2 5 °C → rt; 2 h, rt

Reference

Process for preparation of difluoromethyl containing compounds using (difluoromethyl)trialkylammonium salts

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Production Method 2

17378-82-4

44498-05-7

533-58-4

920981-12-0

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Dimethylformamide ;  4 h, 75 °C

Reference

Decarboxylative Trifluoromethylating Reagent [Cu(O2CCF3)(phen)] and Difluorocarbene Precursor [Cu(phen)2][O2CCF2Cl]

Lin, Xiaoxi; Hou, Chuanqi; Li, Haohong; Weng, Zhiqiang, Chemistry - A European Journal, 2016, 22(6), 2075-2084

Production Method 3

533-58-4

384-67-8

920981-12-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Acetonitrile ,  Water ;  -78 °C; -78 °C → 80 °C; 4 h, 80 °C

Reference

2-Chloro-2,2-difluoroacetophenone: A Non-ODS-based difluorocarbene precursor and its use in the difluoromethylation of phenol derivatives

Zhang, Laijun; Zheng, Ji; Hu, Jinbo, Journal of Organic Chemistry, 2006, 71(26), 9845-9848

Production Method 4

1577210-68-4

920981-12-0

Reaction Conditions

1.1 Reagents: Phosphorus pentachloride Solvents: Dichloromethane ;  12 h, 35 °C
1.2 Reagents: Hydrofluoric acid Solvents: Tetrahydrofuran ;  12 h, rt
1.3 Solvents: Water ;  rt

Reference

Three step procedure for the preparation of aromatic and aliphatic difluoromethyl ethers from phenols and alcohols using a chlorine/fluorine exchange methodology

Dolbier, William R. Jr.; Wang, Fei; Tang, Xiaojun; Thomoson, Charles S.; Wang, Linhua, Journal of Fluorine Chemistry, 2014, 160, 72-76

Production Method 5

533-58-4

1004517-48-9

920981-12-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Acetonitrile ;  10 min, 5 °C
1.2 5 °C; 1.5 h, 5 °C → rt
1.3 Reagents: Water ;  rt

Reference

Difluoromethylation of O-, S-, N-, C-nucleophiles using difluoromethyltri(n-butyl)ammonium chloride as a new difluorocarbene source

Wang, Fei; Huang, Weizhou; Hu, Jinbo, Chinese Journal of Chemistry, 2011, 29(12), 2717-2721

Production Method 6

1535-65-5

533-58-4

920981-12-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Acetonitrile ,  Water ;  5 h, 50 °C

Reference

Chlorodifluoromethyl phenyl sulfone: a novel non-ozone-depleting substance-based difluorocarbene reagent for O- and N-difluoromethylations

Zheng, Ji; Li, Ya; Zhang, Laijun; Hu, Jinbo; Meuzelaar, Gerrit Joost; et al, Chemical Communications (Cambridge, 2007, (48), 5149-5151

Production Method 7

930836-30-9

533-58-4

920981-12-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Acetonitrile ,  Water ;  4 h, 60 °C; 60 °C → rt

Reference

Method for preparation of difluoromethyl-containing compound

, China, , ,

Production Method 8

354-08-5

533-58-4

920981-12-0

Reaction Conditions

1.1 Reagents: Cesium carbonate Catalysts: fac-Tris(2-(2-pyridinyl)phenyl)iridium Solvents: Dimethylformamide ;  12 h, 25 °C

Reference

Visible-Light Photoredox Difluoromethylation of Phenols and Thiophenols with Commercially Available Difluorobromoacetic Acid

Yang, Jinyan; Jiang, Min; Jin, Yunhe; Yang, Haijun; Fu, Hua, Organic Letters, 2017, 19(10), 2758-2761

Production Method 9

533-58-4

920981-12-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  0.5 h, 60 - 70 °C
1.2 4 - 5 h, 60 - 70 °C; 12 h, 60 - 70 °C
1.3 Reagents: Water

Reference

Preparation of tricyclic compounds as mPGES-1 inhibitors

, World Intellectual Property Organization, , ,

1-(Difluoromethoxy)-2-iodobenzene Raw materials

• Bromodifluoroacetic acid
• Phenol, 2-iodo-, 1-formate
• Difluoromethyl Phenyl Sulfone
• Copper(1+),bis(1,10-phenanthroline-kN1,kN10)-, (T-4)-
• Acetic acid, 2-chloro-2,2-difluoro-, ion(1-)
• Chloro(difluoro)methylsulfonylbenzene
• 2-Iodophenol
• 2-chloro-2,2-difluoro-1-phenylethan-1-one
• N,N-Dibutyl-N-(difluoromethyl)-1-butanaminium Chloride (1:1)

1-(Difluoromethoxy)-2-iodobenzene Preparation Products

• 1-(Difluoromethoxy)-2-iodobenzene (920981-12-0)

• 1. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 2. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 3. An investigation on the interaction modes of a single-strand DNA aptamer and RBP4 protein: a molecular dynamic simulations approach?
  Raheleh Torabi,Hedayatollah Ghourchian,Massoud Amanlou Org. Biomol. Chem., 2016,14, 8141-8153
• 4. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 5. Acetyl protected thiol methacrylic polymers as effective ligands to keep quantum dots in luminescent standby mode?
  Marta Liras,Isabel Quijada-Garrido,Marta Palacios-Cuesta,Sonia Mu?oz-Durieux,Olga García Polym. Chem., 2014,5, 433-442

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

• 198206-33-6(1-Iodo-3-(trifluoromethoxy)benzene)
• 897670-96-1(Benzene, 4-chloro-1-(difluoromethoxy)-2-iodo-)
• 873203-37-3(Benzene, 1-(4-iodophenoxy)-4-(trifluoromethoxy)-)
• 405517-72-8(Phenol, 2,6-diiodo-4-(trifluoromethoxy)-)
• 529-28-2(2-Iodoanisole)
• 128140-82-9(1-(Difluoromethoxy)-4-iodobenzene)
• 518070-17-2(3-(Difluoromethoxy)iodobenzene)
• 1000575-32-5(4-bromo-2-(difluoromethoxy)-1-iodobenzene)
• 103962-05-6(1-Iodo-4-(trifluoromethoxy)benzene)
• 175278-00-9(1-Iodo-2-(trifluoromethoxy)benzene)