- Deazapurines, thienopyrimidines and furopyrimidines as phosphoinositide 3-kinase inhibitors with a zinc binding moiety and their preparation and use in the treatment of diseases, United States, , ,
Cas no 920304-57-0 (2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
920304-57-0 structure
Product Name:2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No:920304-57-0
MF:C16H26BNO2
MW:275.1941447258
MDL:MFCD10000956
CID:757662
PubChem ID:87559845
Update Time:2024-10-26
2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Chemical and Physical Properties
Names and Identifiers
-
- Benzenamine,N,N-diethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- N,N-diethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
- N,N-diethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)Benzenamine
- 4-(Diethylamino)phenylboronic Acid Pinacol Ester
- 2-[4-(Diethylamino)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- WVPMYKCIKQQJIV-UHFFFAOYSA-N
- N,N-diethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
- OR16404
- D3601
- 4-(Diethylamino)phenylboronic Acid Pinaco
- N,N-Diethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine (ACI)
- 4,4,5,5-Tetramethyl-2-(4-diethylaminophenyl)-1,3,2-dioxaborolane
- Diethyl[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]amine
- N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N,N-diethylamine
- BCP31412
- AKOS015838659
- 920304-57-0
- Z2044807255
- AS-55614
- CS-0176004
- SCHEMBL1091446
- EN300-1674533
- 2-[4-(Diethylamino)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;4-(Diethylamino)phenylboronic Acid Pinacol Ester
- 4-(Diethylamino)benzeneboronic acid,pinacol ester
- MFCD10000956
- Diethyl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-amine
- T71460
- DTXSID30659782
- DA-40518
- 2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
-
- MDL： MFCD10000956
- Inchi： 1S/C16H26BNO2/c1-7-18(8-2)14-11-9-13(10-12-14)17-19-15(3,4)16(5,6)20-17/h9-12H,7-8H2,1-6H3
- InChI Key： WVPMYKCIKQQJIV-UHFFFAOYSA-N
- SMILES： O1C(C)(C)C(C)(C)OB1C1C=CC(N(CC)CC)=CC=1
Computed Properties
- Exact Mass: 275.20600
- Monoisotopic Mass: 275.206
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 20
- Rotatable Bond Count: 4
- Complexity: 304
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: nothing
- Topological Polar Surface Area: 21.7
Experimental Properties
- Density: 0.995
- Boiling Point: 377.028°C at 760 mmHg
- Flash Point: 181.82°C
- Refractive Index: 1.504
- PSA: 21.70000
- LogP: 2.83200
2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Security Information
-
Symbol:
- Prompt：warning
- Hazard Statement： H315-H319
- Warning Statement： P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | D3601-1g |
2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane |
920304-57-0 | 98.0%(GC) | 1g |
￥990.0 | 2022-06-10 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | N870958-200mg |
N,N-Diethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline |
920304-57-0 | 98% | 200mg |
320.40 | 2021-05-17 | |
| TRC | D473573-25mg |
2-[4-(Diethylamino)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane |
920304-57-0 | 25mg |
$64.00 | 2023-05-18 | ||
| TRC | D473573-50mg |
2-[4-(Diethylamino)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane |
920304-57-0 | 50mg |
$75.00 | 2023-05-18 | ||
| TRC | D473573-100mg |
2-[4-(Diethylamino)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane |
920304-57-0 | 100mg |
$87.00 | 2023-05-18 | ||
| TRC | D473573-250mg |
2-[4-(Diethylamino)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane |
920304-57-0 | 250mg |
$98.00 | 2023-05-18 | ||
| Apollo Scientific | OR16404-250mg |
4-(Diethylamino)benzeneboronic acid, pinacol ester |
920304-57-0 | 98% | 250mg |
￡50.00 | 2024-05-25 | |
| Apollo Scientific | OR16404-1g |
4-(Diethylamino)benzeneboronic acid, pinacol ester |
920304-57-0 | 98% | 1g |
￡150.00 | 2024-05-25 | |
| Apollo Scientific | OR16404-5g |
4-(Diethylamino)benzeneboronic acid, pinacol ester |
920304-57-0 | 98% | 5g |
￡455.00 | 2024-05-25 | |
| TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd. | D3601-1G |
N,N-Diethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline |
920304-57-0 | >98.0%(GC) | 1g |
￥895.00 | 2024-04-15 |
2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ; overnight, 85 °C
Reference
Production Method 2
Reaction Conditions
1.1 Catalysts: 1,10-Phenanthroline , Bis[(1,2,5,6-η)-1,5-cyclooctadiene]di-μ-methoxydiiridium Solvents: Cyclohexane ; 2 min, rt
1.2 12 h, 40 °C
1.2 12 h, 40 °C
Reference
- Meta Selective C-H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic InteractionChaturvedi, Jagriti; Haldar, Chabush; Bisht, Ranjana; Pandey, Gajanan; Chattopadhyay, Buddhadeb, Journal of the American Chemical Society, 2021, 143(20), 7604-7611
Production Method 3
Reaction Conditions
1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ; overnight, 85 °C
Reference
- Treatment of cancers having k-ras mutations using PI3 kinase and HDAC inhibitors and preparation of bifunctional thienopyrimidine compounds that inhibit both enzymes, World Intellectual Property Organization, , ,
Production Method 4
Reaction Conditions
1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran , Hexane ; -78 °C; 1 h, -78 °C
1.2 -78 °C; -78 °C → rt; 12 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; neutralized, rt
1.2 -78 °C; -78 °C → rt; 12 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; neutralized, rt
Reference
- Synthesis and biological activity of new 4-(pyridin-4-yl)-(3-methoxy-5-methylphenyl)-1H-pyrazoles derivatives as ROS receptor tyrosine kinase inhibitorsPark, Byung Sun; El-deeb, Ibrahim M.; Yoo, Kyung Ho; Han, Dong Keun; Tae, Jin Sung; et al, Bulletin of the Korean Chemical Society, 2012, 33(11), 3629-3634
Production Method 5
Reaction Conditions
1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; overnight, rt
Reference
- Preparation of pyridopyrazine compounds as novel syk inhibitors, World Intellectual Property Organization, , ,
Production Method 6
Reaction Conditions
1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; overnight, rt
Reference
- Preparation of pyridopyrazine derivatives for use as Syk inhibitors, World Intellectual Property Organization, , ,
Production Method 7
Reaction Conditions
1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; rt → 0 °C; 30 min, 0 °C
1.2 0 °C; 0 °C → rt; 3 d, rt
1.2 0 °C; 0 °C → rt; 3 d, rt
Reference
- Preparation of benzo[a]carbazole and indeno[1,2-b]indole derivatives as TPO mimetics, World Intellectual Property Organization, , ,
Production Method 8
Reaction Conditions
1.1 Catalysts: 1,10-Phenanthroline , Bis[(1,2,5,6-η)-1,5-cyclooctadiene]di-μ-methoxydiiridium Solvents: Cyclohexane ; 12 h, 40 °C
Reference
- Electrostatically Directed meta Selective Borylation of ArenesChaturvedi, Jagriti; Haldar, Chabush; Chattopadhyay, Buddhadeb, Synlett, 2022, 33(12), 1108-1116
2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Raw materials
- N,N-Diethylaniline
- 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- Bis(pinacolato)diborane
- 4-Bromo-N,N-diethylaniline
- 4-Aminophenylboronic acid pinacol ester
2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Preparation Products
2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Related Literature
-
Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
-
J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
-
Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
920304-57-0 (2-4-(Diethylamino)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane) Related Products
- 871125-87-0(Piperazine,1-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-)
- 852227-90-8(1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine)
- 656257-45-3(1-Ethyl-4-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylpiperazine)
- 747413-18-9(1-methyl-4-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine)
- 912369-50-7(1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine)
- 1073354-18-3(4-(4-Isopropylpiperizinyl)phenylboronic acid, pinacol ester)
- 747413-21-4(1-methyl-4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine)
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- 857283-63-7(3-(Pyrrilidyl)phenylboronic Acid pinacol ester)
- 852227-96-4(1-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenylpiperidine)
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