- Mg- and Zn-mediated synthesis of heterocycles in solution and on the solid phaseBerillon, Laurent, 2000, , ,
Cas no 920-39-8 (Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran))
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) is a highly reactive Grignard reagent commonly employed in organic synthesis for nucleophilic addition and metal-halogen exchange reactions. The solution offers consistent reactivity due to its standardized concentration (2.9 M) and is stabilized in 2-methyltetrahydrofuran (2-MeTHF), a greener alternative to traditional ether solvents with improved safety and lower peroxide formation risk. This formulation ensures efficient handling and storage while maintaining high purity. Its applications span pharmaceutical intermediates, fine chemicals, and complex molecule construction. The solvent's low water solubility also minimizes side reactions, enhancing yield and selectivity in sensitive transformations. Suitable for air- and moisture-sensitive protocols under inert conditions.
920-39-8 structure
Product Name:Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran)
CAS No:920-39-8
MF:C3H7BrMg
MW:147.296680688858
MDL:MFCD00672110
CID:805204
PubChem ID:87571866
Update Time:2025-05-22
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) Chemical and Physical Properties
Names and Identifiers
-
- Isopropylmagnesium Bromide
- 2-Propylmagnesium bromide
- ISOPROPYLMAGNESIUM BROMIDE 3.0M 2-methyltetrahydrofuran
- Isopropylmagnesium bromide, 1.0 M solution in THF, in resealable bottle
- Isopropylmagnesium bromide, 1.0 M solution in THF, SpcSeal
- Magnesium,bromo(1-methylethyl)-
- Isopropylmagnesium Bromide 2.0 M In Diethyl Ether
- 1.0 M solution in THF, MkSeal
- 2.9 M in 2-Methyltetrahydrofuran, MkSeal
- IsopropylMagnesiuM broMide, 3M in 2-MeTHF
- IsopropylMagnesiuM broMide, 3M solution in 2-MeTHF, AcroSeal
- Isopropylmagnesium bromide, 3M solution in 2-Methyltetrahydrofuran, AcroSeal
- Magnesium, bromo(1-methylethyl)-
- Bromo(1-methylethyl)magnesium
- isopropylmagnesiumbromide
- isopropyl magnesium bromide
- iPrMgBr
- i-PrMgBr
- Bromoisopropylmagnesium
- i-propylmagnesiumbromide
- i-propylmagnesium bromide
- Bromo-isopropyl-magnesium
- isopropyl-magnesium bromide
- iso-propylmagnesium bromide
- iso-propyl magnesium bromide
- iso-propyl-magnesium bromide
- UCJIVFREPMUZDC-UHFFFAOYSA-M
- Bromo(1-methylethyl)magnesium (ACI)
- Isopropylmagnesium bromide (6CI)
- Magnesium, bromoisopropyl- (7CI, 8CI)
- Magnesium, isopropyl-, bromide (4CI)
- 1-Methylethylmagnesium bromide
- NS00079590
- 920-39-8
- J-802234
- MFCD00672110
- AKOS015902497
- Isopropylmagnesium bromide, 3 M in 2-MeTHF
- SCHEMBL5233
- DB-370619
- i-Propylmagnesium bromide, 2.9M (35wt% ?1wt%) in 2-methyltetrahydrofuran
- BROMO(ISOPROPYL)MAGNESIUM
- Isopropylmagnesium bromide, 1.0 M in THF
- DTXSID1074333
- EINECS 213-056-8
- E80426
- Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran)
-
- MDL： MFCD00672110
- Inchi： 1S/C3H7.BrH.Mg/c1-3-2;;/h3H,1-2H3;1H;/q;;+1/p-1
- InChI Key： UCJIVFREPMUZDC-UHFFFAOYSA-M
- SMILES： Br[Mg]C(C)C
Computed Properties
- Exact Mass: 145.958
- Monoisotopic Mass: 145.958
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 5
- Rotatable Bond Count: 0
- Complexity: 6.9
- Covalently-Bonded Unit Count: 3
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: nothing
Experimental Properties
- Color/Form: Not determined
- Density: 0.982?g/mL?at 25?°C
- Melting Point: 114-116 oC
- Boiling Point: 148-154 oC
- Flash Point: Fahrenheit: -22 ° f
Celsius: -30 ° c - Solubility: Miscible with tetrahydorfuran and diethyl ether. Immiscible with hydrocarbons.
- LogP: 2.20960
- Sensitiveness: Air & Moisture Sensitive
- Color/Form: 0.75?M in THF
- Solubility: Not determined
- Vapor Pressure: No data available
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) Security Information
-
Symbol:
- Prompt：dangerous
- Signal Word：Danger
- Hazard Statement： H225,H261,H314
-
Warning Statement：
P210,P231
P232,P303
P361
P353,P305
P351
P338,P405,P501A - Hazardous Material transportation number：UN 2056 3 / PGII
- WGK Germany：1
- Hazard Category Code： 11-14/15-19-34-37-40
- Safety Instruction： 16-26-36/37/39-43-45
-
Hazardous Material Identification：
- HazardClass：4.3
- PackingGroup：I
- TSCA：Yes
- Storage Condition：2-8°C
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | I129155-500ml |
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) |
920-39-8 | 1.0 M in THF | 500ml |
￥337.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | I129155-1L |
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) |
920-39-8 | 1.0 M in THF | 1l |
￥518.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | I129155-100ml |
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) |
920-39-8 | 1.0 M in THF | 100ml |
￥95.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | I129155-800ml |
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) |
920-39-8 | 1.0 M in THF | 800ml |
￥498.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | I121129-100ml |
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) |
920-39-8 | 2.9M in 2-methyltetrahydrofuran | 100ml |
￥91.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | I121129-800ml |
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) |
920-39-8 | 2.9M in 2-methyltetrahydrofuran | 800ml |
￥546.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | I121129-1L |
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) |
920-39-8 | 2.9M in 2-methyltetrahydrofuran | 1l |
￥559.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | I121129-500ml |
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) |
920-39-8 | 2.9M in 2-methyltetrahydrofuran | 500ml |
￥365.90 | 2023-09-02 | |
| A FA AI SHA ， SAI MO FEI SHI ER KE JI QI XIA GONG SI | H54840-100ml |
Isopropylmagnesium bromide, 3M in 2-MeTHF |
920-39-8 | 100ml |
￥5958.00 | 2023-04-13 | ||
| TRC | I920390-100ml |
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) |
920-39-8 | 100ml |
175.00 | 2021-08-04 |
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Magnesium Solvents: Tetrahydrofuran
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Magnesium , Iodine Solvents: Tetrahydrofuran ; heated; 10 °C; overnight, rt
Reference
- Iron-Catalyzed Cross-Coupling of Thioesters and Organomanganese ReagentsGeiger, Valentin Jacob ; Lefevre, Guillaume; Fleischer, Ivana, Chemistry - A European Journal, 2022, 28(62),
Production Method 3
Reaction Conditions
1.1 Reagents: Magnesium Catalysts: 1,2-Dibromoethane Solvents: Tetrahydrofuran ; 1.5 h, rt
1.2 Solvents: Tetrahydrofuran ; 45 min, rt; 2 h, rt
1.2 Solvents: Tetrahydrofuran ; 45 min, rt; 2 h, rt
Reference
- Synthesis of 1- and 1,2-Substituted Cyclopropylamines from Ketone HomoenolatesWest, Michael S.; Pia, Julia E.; Rousseaux, Sophie A. L., Organic Letters, 2022, 24(32), 5869-5873
Production Method 4
Reaction Conditions
1.1 Reagents: Magnesium
Reference
- Regio- and Diastereoselective Copper-Catalyzed Carbomagnesiation for the Synthesis of Penta- and Hexa-Substituted CyclopropanesCohen, Yair; Augustin, Andre U.; Levy, Laura; Jones, Peter G.; Werz, Daniel B.; et al, Angewandte Chemie, 2021, 60(21), 11804-11808
Production Method 5
Reaction Conditions
1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran ; heated; 1 - 4 h, rt
Reference
- 1,n-Bisborylalkanes via Radical Boron MigrationWang, Dinghai ; Mueck-Lichtenfeld, Christian; Studer, Armido, Journal of the American Chemical Society, 2020, 142(20), 9119-9123
Production Method 6
Reaction Conditions
1.1 Reagents: Magnesium
Reference
- Iminyl radical-promoted imino sulfonylation, imino cyanogenation and imino thiocyanation of γ,δ-unsaturated oxime esters: synthesis of versatile functionalized pyrrolinesWang, Yuebo; Ding, Jie; Zhao, Jinghui; Sun, Wan; Lian, Chang; et al, Organic Chemistry Frontiers, 2019, 6(13), 2240-2244
Production Method 7
Reaction Conditions
1.1 Reagents: Magnesium , Iodine Solvents: Diethyl ether
Reference
- Pd-Catalyzed carboannulation of γ,δ-alkenyl oximes: efficient access to 5-membered cyclic nitrones and dihydroxazinesSun, Baozhen; Liu, Shuang; Zhang, Mengru; Zhao, Jinbo; Zhang, Qian, Organic Chemistry Frontiers, 2019, 6(3), 388-392
Production Method 8
Reaction Conditions
1.1 Reagents: Magnesium
Reference
- Grignard Reagents and Their N-analogues in the Synthesis of Tricyclic and Tetracyclic Cage-like LactamsTkachenko, Igor V.; Tarabara, Igor N.; Omelchenko, Irina V.; Palchykov, Vitalii A., Journal of Heterocyclic Chemistry, 2018, 55(10), 2381-2391
Production Method 9
Reaction Conditions
1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Diethyl ether ; > rt; heated; 2 h, rt
Reference
- Method for preparing silahydrocarbons, World Intellectual Property Organization, , ,
Production Method 10
Reaction Conditions
1.1 Reagents: Magnesium Solvents: Tetrahydrofuran
Reference
- Transition Metal-Catalyzed Cross-Coupling Reactions of Functionalized Organometallic ReagentsJensen, Anne Eeg, 2001, , ,
Production Method 11
Reaction Conditions
1.1 Reagents: Magnesium
Reference
- Visible light-induced N-radical 5-exo/6-endo cyclization of alkenyl amides: facile access to isoindolinones/isoquinolinonesLei, Zhen-Yao; Hu, Kui; He, Yuan-Xiang; Geng, Shu; Chen, Li-Na; et al, Organic & Biomolecular Chemistry, 2022, 20(12), 2397-2401
Production Method 12
Reaction Conditions
1.1 Reagents: Magnesium Solvents: Tetrahydrofuran
Reference
- Mechanochemical Magnesium-Mediated Minisci C-H Alkylation of Pyrimidines with Alkyl Bromides and ChloridesWu, Chongyang; Ying, Tao; Yang, Xinjie; Su, Weike; Dushkin, Alexandr V.; et al, Organic Letters, 2021, 23(16), 6423-6428
Production Method 13
Reaction Conditions
1.1 Reagents: Magnesium Solvents: Diethyl ether ; > 1 min, rt
Reference
- Application method of Grignard reaction by two-way dripping of halide and electrophilic reagent for preparation of Grignard reagent and allowing reaction of Grignard reagent with aldehyde or ketone at the same time, China, , ,
Production Method 14
Reaction Conditions
1.1 Reagents: Magnesium Solvents: Tetrahydrofuran ; reflux; 30 min, reflux
Reference
- Concise chemoenzymatic total synthesis and identification of cellular targets of cepafungin IAmatuni, Alexander; Shuster, Anton; Adibekian, Alexander; Renata, Hans, ChemRxiv, 2020, 1, 1-7
Production Method 15
Reaction Conditions
1.1 Reagents: Magnesium Solvents: Tetrahydrofuran ; 0 °C → rt
Reference
- Silver-promoted cascade radical cyclization of γ,δ-unsaturated oxime esters with P(O)H compounds: synthesis of phosphorylated pyrrolinesChen, Chen; Bao, Yinwei; Zhao, Jinghui; Zhu, Bolin, Chemical Communications (Cambridge, 2019, 55(97), 14697-14700
Production Method 16
Reaction Conditions
1.1 Reagents: Magnesium
Reference
- Copper-Catalyzed Group-Transfer Radical Cyclization of γ,δ-Unsaturated Oxime Esters: Synthesis of Ester-Functionalized PyrrolinesZhao, Jinghui; Bao, Yinwei; Wang, Yuebo; Chen, Chen; Zhu, Bolin, Asian Journal of Organic Chemistry, 2019, 8(8), 1317-1320
Production Method 17
Reaction Conditions
1.1 Reagents: 1,2-Dibromoethane , Magnesium Solvents: Tetrahydrofuran ; 5 min, rt
Reference
- Unified Total Synthesis of Madangamine AlkaloidsSuto, Takahiro; Yanagita, Yuta; Nagashima, Yoshiyuki; Takikawa, Shinsaku; Kurosu, Yasuhiro; et al, Bulletin of the Chemical Society of Japan, 2019, 92(3), 545-571
Production Method 18
Reaction Conditions
1.1 Reagents: Magnesium Solvents: Tetrahydrofuran
Reference
- Synthesis, properties, and catalytic application of a triptycene-type borate-phosphine ligandKonishi, Shota; Iwai, Tomohiro; Sawamura, Masaya, Organometallics, 2018, 37(12), 1876-1883
Production Method 19
Production Method 20
Reaction Conditions
1.1 Reagents: Magnesium Solvents: 2-Methyltetrahydrofuran ; 50 - 60 °C; 2 h, 60 - 65 °C
Reference
- Production process for Grignard reagent, China, , ,
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) Raw materials
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) Preparation Products
Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) Suppliers
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Isopropylmagnesium Bromide Solution (2.9 M in 2-methyltetrahydrofuran) Related Literature
-
J. M. Granadino-Roldán,M. Fernández-Gómez,A. Navarro,T. Pe?a Ruiz,U. A. Jayasooriya Phys. Chem. Chem. Phys., 2004,6, 1133-1143
-
Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
-
Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
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