Production Method 1

103-40-2

91970-62-6

Reaction Conditions

1.1 Reagents: (Dimethyl sulfide)trihydroboron Solvents: Tetrahydrofuran ;  -18 °C; 1 h, -18 °C; -18 °C → rt; 5.5 h, rt; rt → 0 °C

Reference

Synthesis of the Polyketide (E)-Olefin of the Jamaicamides

Watanabe, Satoshi; Watanabe, Sho; Aoki, Naoto; Usuki, Toyonobu, Synthetic Communications, 2013, 43(10), 1397-1403

Production Method 2

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Water
1.2 Reagents: Tetrabutylammonium iodide Solvents: Acetone

Reference

Development of Methods for the Synthesis of an Analogue of Rhazinilame

Vallat, Olivier, 2004, , ,

Production Method 3

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water
1.2 Reagents: Tetrabutylammonium bromide Solvents: Acetone

Reference

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

Weber, Ann E.; Halgren, Thomas A.; Doyle, John J.; Lynch, Robert J.; Siegl, Peter K. S.; et al, Journal of Medicinal Chemistry, 1991, 34(9), 2692-701

Production Method 4

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  rt → 70 °C; 12 h, 70 °C
1.2 Catalysts: Tetrabutylammonium iodide Solvents: Acetone ;  6 h, reflux; overnight, rt

Reference

Novel aminophosphinic derivatives as aminopeptidase A inhibitors

, World Intellectual Property Organization, , ,

Production Method 5

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  1 h, 100 °C
1.2 Catalysts: Tetrabutylammonium fluoride Solvents: Acetone ;  3 h, reflux

Reference

Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof

, World Intellectual Property Organization, , ,

Production Method 6

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  overnight, 100 °C
1.2 Solvents: Acetone ;  overnight, 60 °C

Reference

Cyclic peptide-n-acetylgalactosamine conjugates for drug delivery to liver cells

, World Intellectual Property Organization, , ,

Production Method 7

91970-62-6

Reaction Conditions

1.1 Reagents: Tetrabutylammonium hydroxide Solvents: Methanol ;  2 h, 70 °C
1.2 Solvents: Dimethylformamide ;  16 h, 25 °C

Reference

Preparation of prodrugs of neuroactive steroids brexanolone, ganaxolone, and zuranolone

, World Intellectual Property Organization, , ,

Production Method 8

86170-45-8

91970-62-6

Reaction Conditions

Reference

Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin-infused rat model and in conscious sodium-depleted monkeys

Thaisrivongs, Suvit; Pals, Donald T.; DuCharme, Donald W.; Turner, Steve R.; DeGraaf, Garry L.; et al, Journal of Medicinal Chemistry, 1991, 34(2), 633-42

Production Method 9

90318-49-3

91970-62-6

Reaction Conditions

1.1 Catalysts: Tetrabutylammonium bromide Solvents: Acetone ;  12 h, 60 °C

Reference

Synthesis of modified amine lipids for lipid nanoparticle compositions that deliver nucleic acid cargo

, World Intellectual Property Organization, , ,

Production Method 10

103-40-2

91970-62-6

Reaction Conditions

1.1 Reagents: (Dimethyl sulfide)trihydroboron Solvents: Tetrahydrofuran ;  1 h, 5 - 10 °C; 6 h, 25 - 30 °C; 30 °C → 0 °C
1.2 Reagents: Potassium carbonate Solvents: Water

Reference

Compounds and compositions comprising sunitinib, brinzolamide, or dorzolamide prodrugs for ocular delivery, to treat glaucoma

, World Intellectual Property Organization, , ,

Production Method 11

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  24 h, 70 °C
1.2 Catalysts: Tetrabutylammonium bromide Solvents: Acetone ;  24 h, reflux

Reference

Syntheses of glycoclusters containing a phosphocholine residue related to a glycosphingolipid from the earthworm Pheretima hilgendorfi

Hada, Noriyasu; Shida, Yukihiko; Negishi, Natsuko; Schweizer, Frank; Takeda, Tadahiro, Chemical & Pharmaceutical Bulletin, 2009, 57(10), 1081-1088

Production Method 12

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  rt → 70 °C; 12 h, 70 °C
1.2 Catalysts: Tetrabutylammonium iodide Solvents: Acetone ;  6 h, reflux; overnight, reflux → rt; 6 h, reflux

Reference

Aminopeptidase A inhibitors and pharmaceutical compositions comprising the same

, World Intellectual Property Organization, , ,

Production Method 13

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ;  rt; 5 - 6 h, > 30 °C
1.2 Solvents: Dimethyl sulfoxide ;  > 30 °C; 3 h, rt; rt → 15 °C
1.3 Reagents: Water

Reference

Methods of synthesizing 4-valyloxybutyric acid

, World Intellectual Property Organization, , ,

Production Method 14

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  overnight, 70 °C
1.2 Catalysts: Tetrabutylammonium bromide Solvents: Acetone ;  overnight, reflux

Reference

Inverse Electron-Demand Diels-Alder Bioconjugation Reactions Using 7-Oxanorbornenes as Dienophiles

Agramunt, Jordi ; Ginesi, Rebecca; Pedroso, Enrique ; Grandas, Anna, Journal of Organic Chemistry, 2020, 85(10), 6593-6604

Production Method 15

91970-62-6

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Dichloromethane
1.2 Reagents: Sodium hydroxide Solvents: Water ;  24 h, 70 °C
1.3 Reagents: Tetrabutylammonium bromide Solvents: Acetone ,  Toluene ;  24 h, 60 °C

Reference

A new template of Mitsunobu acylate cleavable in non-alkaline conditions

Sakakibara, Yoshimichi; Sai, Yusuke; Uraki, Yasumitsu; Ubukata, Makoto; Shigetomi, Kengo, Heterocycles, 2022, 104(1), 140-158

Production Method 16

103-40-2

91970-62-6

Reaction Conditions

1.1 Reagents: (Dimethyl sulfide)trihydroboron Solvents: Tetrahydrofuran ;  0 °C; 1 h, 0 °C; 5.5 h, rt; rt → 0 °C
1.2 Reagents: Potassium carbonate Solvents: Diethyl ether ,  Water

Reference

Phosphoramidate derivates as controlled-release prodrugs of L-Dopa

Olatunji, Feyisola P.; Kesic, Brittany N.; Choy, Cindy J.; Berkman, Clifford E., Bioorganic & Medicinal Chemistry Letters, 2019, 29(18), 2571-2574

Production Method 17

91970-62-6

Reaction Conditions

1.1 Reagents: Tetrabutylammonium hydroxide Solvents: Methanol ;  7 h, rt → 90 °C

Reference

Aminoquinazoline derivatives as HER-2 inhibitors and their preparation, pharmaceutical compositions and use in the treatment of proliferative diseases

, China, , ,

Production Method 18

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Catalysts: Tetrabutylammonium bromide Solvents: Acetone ;  rt; rt → 65 °C; overnight, 65 °C
1.2 Solvents: Water

Reference

Di-(benzimidazole)-1, 2, 3-triazole derivative and preparation therefor and use thereof

, World Intellectual Property Organization, , ,

Production Method 19

91970-62-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide Catalysts: Tetrabutylammonium bromide Solvents: Acetone ;  rt; rt → 65 °C; overnight, 65 °C; 65 °C → rt
1.2 Reagents: Water ;  rt

Reference

Di-(benzimidazole)-1,2,3-triazole derivatives and preparation and application thereof in inflammatory dermatoses

, China, , ,

Production Method 20

502-85-2

91970-62-6

Reaction Conditions

1.1 Reagents: Tetrabutylammonium hydrogen sulfate Solvents: Dichloromethane ,  Water ;  4 d, rt

Reference

Haptens for preparing antibodies for the detection of EPN by enzyme-linked immunosorbent assays

, Korea, , ,

4-Hydroxybutyric Acid Benzyl Ester Raw materials

• Butanoic acid, 4-hydroxy-, sodium salt
• Succinic Acid Monobenzyl Ester
• SODIUM 4-HYDROXYBUTYRATE
• 3-Butenoic acid, phenylmethyl ester

4-Hydroxybutyric Acid Benzyl Ester Preparation Products

• 4-Hydroxybutyric Acid Benzyl Ester (91970-62-6)

• 1. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 2. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 3. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 4. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 5. An antimonate pyrochlore (H1.23Sr0.45SbO3.48) for photocatalytic oxidation of benzene: effective oxygen usage and excellent activity?
  Jing Chen,Yu Shao,Danzhen Li J. Mater. Chem. A, 2017,5, 937-941

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyloxycarbonyls

• 6938-45-0(Hexanoic acid,phenylmethyl ester)
• 6471-66-5(Benzyl nonanoate)
• 79275-69-7(Dodecanedioic acid, bis(phenylmethyl) ester)
• 31161-71-4(Tetradecanoic acid,phenylmethyl ester)
• 103-40-2(Succinic Acid Monobenzyl Ester)
• 103-43-5(dibenzyl succinate)
• 74978-19-1(Heptadecanoic acid,phenylmethyl ester)
• 103-37-7(Benzyl butyrate)
• 3089-55-2(Benzyl octyl adipate)
• 140-21-6(Butanedioic acid,1-(phenylmethyl) ester, sodium salt (1:1))