Production Method 1

189321-63-9

919354-20-4

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane ;  2 h, rt

Reference

Preparation of piperidinylpyrrolopyrimidines as LIM kinase 2 (LIMK2) inhibitors

, United States, , ,

Production Method 2

189321-63-9

919354-20-4

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Cyclopentyl methyl ether ;  overnight, rt

Reference

Heterocyclic spiro-compounds as AM2 receptor inhibitors and their preparation

, World Intellectual Property Organization, , ,

Production Method 3

189321-63-9

919354-20-4

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane ;  0 °C; 5 h, rt

Reference

Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent

Cao, Yangzhi; Kong, Deyu; Sun, Lulu; Meng, Xin; Zhang, Yinyong; et al, ChemistrySelect, 2021, 6(13), 3183-3186

Production Method 4

189321-63-9

919354-20-4

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane ;  15 h, rt

Reference

Preparation of aminomethyl-2H-chromene compounds and derivative thereof as agonists of S1P1 receptor

, World Intellectual Property Organization, , ,

Production Method 5

892493-16-2

919354-20-4

Reaction Conditions

1.1 Reagents: Potassium trimethylsilanolate Solvents: Tetrahydrofuran ;  overnight, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane ;  rt

Reference

Pyridine analogs as P2Y12 inhibitors and their preparation, pharmaceutical compositions and use in the treatment of platelet aggregation disorders

, World Intellectual Property Organization, , ,

Production Method 6

892493-16-2

919354-20-4

Reaction Conditions

1.1 Reagents: Potassium trimethylsilanolate Solvents: Tetrahydrofuran ;  overnight, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: 1,4-Dioxane

Reference

Preparation of pyridine derivatives as P2Y12 inhibitors

, World Intellectual Property Organization, , ,

4-methylpiperidine-4-carboxylic acid;hydrochloride Raw materials

• 1-tert-butoxycarbonyl-4-methyl-piperidine-4-carboxylic acid
• methyl 4-methylpiperidine-4-carboxylate

4-methylpiperidine-4-carboxylic acid;hydrochloride Preparation Products

• 4-methylpiperidine-4-carboxylic acid;hydrochloride (919354-20-4)

• 1. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 2. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 3. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 4. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 5. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids and derivatives Piperidinecarboxylic acids

• 1227465-56-6(4-Propylpiperidine-4-carboxylic acid)
• 71235-92-2(1-Methylpiperidine-4-carboxylic acid hydrochloride)
• 5984-56-5(Isonipecotic acid hydrochloride)
• 62581-22-0(Piperidinium, 4-carboxy-1,1-dimethyl-, chloride)
• 40117-63-3(1-azabicyclo[2.2.2]octane-4-carboxylic acid hydrochloride)
• 1227465-48-6(4-Ethylpiperidine-4-carboxylic acid hydrochloride)
• 1185325-87-4(1,4-Dimethylpiperidine-4-carboxylic acid hydrochloride)
• 71985-80-3(1-methylpiperidine-4-carboxylic acid;hydrochloride)
• 162648-32-0(4-Methyl-4-piperidinecarboxylic Acid)
• 52700-61-5( )