Production Method 1

387-43-9

919295-78-6

Reaction Conditions

1.1 Catalysts: Tris[2-(2-pyridinyl-κN)phenyl-κC]iridium Solvents: Dichloromethane ;  8 h, rt

Reference

C-H functionalization of heterocycles with triplet carbenes via an unexpected 1,2-alkyl radical migration

Empel, Claire; Jana, Sripati; Ciszewski, Lukasz; Zawada, Katarzyna; Pei, Chao; et al, ChemRxiv, 2022, 1, 1-12

Production Method 2

105-36-2

387-43-9

919295-78-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  15 min, < 0 °C
1.2 Reagents: Zinc chloride Solvents: Ethanol ;  0 °C → rt; 24 h, rt
1.3 Solvents: Toluene ;  24 h, rt

Reference

Discovery and Refinement of a New Structural Class of Potent Peptide Deformylase Inhibitors

Boularot, Adrien; Giglione, Carmela; Petit, Sylvain; Duroc, Yann; de Sousa, Rodolphe Alves; et al, Journal of Medicinal Chemistry, 2007, 50(1), 10-20

Production Method 3

387-43-9

919295-78-6

Reaction Conditions

1.1 Catalysts: Copper(II) triflate Solvents: Dichloromethane ;  > rt; overnight, rt

Reference

Preparation of indole and indazole derivatives as muscarinic M1 receptor pos. allosteric modulators

, World Intellectual Property Organization, , ,

Production Method 4

387-43-9

919295-78-6

Reaction Conditions

1.1 Catalysts: Tris[2-(2-pyridinyl-κN)phenyl-κC]iridium Solvents: Dichloromethane ;  8 h, rt

Reference

C-H Functionalization of Heterocycles with Triplet Carbenes by means of an Unexpected 1,2-Alkyl Radical Migration

Empel, Claire ; Jana, Sripati ; Ciszewski, Lukasz W. ; Zawada, Katarzyna ; Pei, Chao; et al, Chemistry - A European Journal, 2023, 29(29),

Production Method 5

387-43-9

919295-78-6

Reaction Conditions

1.1 Catalysts: Copper(II) triflate Solvents: Dichloromethane ;  rt → 0 °C; 0 °C; 1 h, 0 °C → rt

Reference

Tetrahydropyranoindoles, derivatives thereof, and their methods of synthesis and use

, United States, , ,

Production Method 6

387-43-9

919295-78-6

2254562-03-1

Reaction Conditions

1.1 Catalysts: Copper(II) triflate Solvents: Dichloromethane ;  rt → 0 °C
1.2 Solvents: Dichloromethane ;  0 °C; 1 h, 0 °C → rt

Reference

A Cooperative Hydrogen Bond Donor-Bronsted Acid System for the Enantioselective Synthesis of Tetrahydropyrans

Maskeri, Mark A.; O'Connor, Matthew J.; Jaworski, Ashley A.; Bay, Anna V. ; Scheidt, Karl A., Angewandte Chemie, 2018, 57(52), 17225-17229

1H-Indole-3-acetic acid, 4-fluoro-, ethyl ester Raw materials

• Ethyl bromoacetate
• 4-fluoro-1H-indole

1H-Indole-3-acetic acid, 4-fluoro-, ethyl ester Preparation Products

• 1H-Indole-3-acetic acid, 4-fluoro-, ethyl ester (919295-78-6)
• 2,3-Diethyl 4-fluoro-1H-indole-2,3-diacetate (2254562-03-1)

• 1. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
• 2. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin
• 3. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 4. Achieving crystal-induced room temperature phosphorescence and reversible photochromic properties by strong intermolecular interactions?
  Fuming Xiao,Mengzhu Wang,Yunxiang Lei,Wenbo Dai,Yunbing Zhou,Miaochang Liu,Wenxia Gao,Xiaobo Huang,Huayue Wu J. Mater. Chem. C, 2020,8, 17410-17416
• 5. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indole-3-acetic acid derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indolyl carboxylic acids and derivatives Indole-3-acetic acid derivatives

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)