- Antiviral compounds, their preparation, pharmaceutical compositions, and use in therapy, World Intellectual Property Organization, , ,
Cas no 91870-15-4 (2,5-Dichloro-1,8-naphthyridine)
91870-15-4 structure
Product Name:2,5-Dichloro-1,8-naphthyridine
CAS No:91870-15-4
MF:C8H4Cl2N2
MW:199.036759376526
MDL:MFCD13181698
CID:1039784
PubChem ID:15588316
Update Time:2024-10-26
2,5-Dichloro-1,8-naphthyridine Chemical and Physical Properties
Names and Identifiers
-
- 2,5-Dichloro-1,8-naphthyridine
- 2,5-Dichloro-1,8-phthyridine
- 1,8-Naphthyridine,2,5-dichloro
- 2,5-dichloro-[1,8]naphthyridine
- 1,8-Naphthyridine, 2,5-dichloro-
- PubChem18425
- UXTNCJSJGKRLSV-UHFFFAOYSA-N
- 1,8-Naphthyridine,2,5-dichloro-
- ZB0083
- 5515AC
- FCH1186175
- AX8238371
- 2,5-Dichloro-1,8-naphthyridine (ACI)
- CS-0143250
- AKOS016005761
- MFCD13181698
- DS-13139
- W16859
- SCHEMBL2023814
- DTXSID20575200
- DB-079188
- 91870-15-4
- EN300-3231945
-
- MDL： MFCD13181698
- Inchi： 1S/C8H4Cl2N2/c9-6-3-4-11-8-5(6)1-2-7(10)12-8/h1-4H
- InChI Key： UXTNCJSJGKRLSV-UHFFFAOYSA-N
- SMILES： ClC1C=CC2C(=NC=CC=2Cl)N=1
Computed Properties
- Exact Mass: 197.97500
- Monoisotopic Mass: 197.9751535g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 12
- Rotatable Bond Count: 0
- Complexity: 165
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 25.8
- XLogP3: 3
Experimental Properties
- Density: 1.487
- Boiling Point: 300.4°C at 760 mmHg
- Flash Point: 163.841°C
- Refractive Index: 1.671
- PSA: 25.78000
- LogP: 2.93660
2,5-Dichloro-1,8-naphthyridine Security Information
- Signal Word：Warning
- Hazard Statement： H302-H315-H319-H335
- Warning Statement： P261-P305+P351+P338
- Storage Condition：Inert atmosphere,2-8°C(BD238371)
2,5-Dichloro-1,8-naphthyridine Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
2,5-Dichloro-1,8-naphthyridine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 230766-250mg |
2,5-Dichloro-1,8-naphthyridine |
91870-15-4 | 95% | 250mg |
￡189.00 | 2022-02-28 | |
| Fluorochem | 230766-1g |
2,5-Dichloro-1,8-naphthyridine |
91870-15-4 | 95% | 1g |
￡471.00 | 2022-02-28 | |
| Fluorochem | 230766-5g |
2,5-Dichloro-1,8-naphthyridine |
91870-15-4 | 95% | 5g |
￡1436.00 | 2022-02-28 | |
| Alichem | A219008092-250mg |
2,5-Dichloro-1,8-naphthyridine |
91870-15-4 | 95% | 250mg |
$237.60 | 2023-08-31 | |
| Alichem | A219008092-1g |
2,5-Dichloro-1,8-naphthyridine |
91870-15-4 | 95% | 1g |
$540.00 | 2023-08-31 | |
| Ambeed | A141393-100mg |
2,5-Dichloro-1,8-naphthyridine |
91870-15-4 | 95% | 100mg |
$46.0 | 2025-04-15 | |
| Ambeed | A141393-250mg |
2,5-Dichloro-1,8-naphthyridine |
91870-15-4 | 95% | 250mg |
$75.0 | 2025-04-15 | |
| Ambeed | A141393-1g |
2,5-Dichloro-1,8-naphthyridine |
91870-15-4 | 95% | 1g |
$260.0 | 2025-04-15 | |
| Ambeed | A141393-5g |
2,5-Dichloro-1,8-naphthyridine |
91870-15-4 | 95% | 5g |
$823.0 | 2025-04-15 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-FN333-50mg |
2,5-Dichloro-1,8-naphthyridine |
91870-15-4 | 95+% | 50mg |
583.0CNY | 2021-07-12 |
2,5-Dichloro-1,8-naphthyridine Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Phosphorus oxychloride ; 6 h, 50 °C; 50 °C → rt
1.2 Reagents: Ammonium hydroxide Solvents: Water ; pH 10, cooled
1.2 Reagents: Ammonium hydroxide Solvents: Water ; pH 10, cooled
Reference
Production Method 2
Reaction Conditions
Reference
- Preparation of 1,6- and 1,8-naphthyridines as antiviral compounds for treatment of HCV infections, United States, , ,
Production Method 3
Reaction Conditions
1.1 Reagents: Phosphorus oxychloride ; 6 h, 50 °C; 50 °C → rt
1.2 Reagents: Water ; cooled
1.3 Reagents: Ammonium hydroxide ; pH 10
1.2 Reagents: Water ; cooled
1.3 Reagents: Ammonium hydroxide ; pH 10
Reference
- Preparation of 1,6- and 1,8-naphthyridines as antiviral compounds for treatment of HCV infections, World Intellectual Property Organization, , ,
Production Method 4
Reaction Conditions
1.1 Reagents: Phosphorus oxychloride ; 6 h, 105 °C
1.2 Reagents: Sodium carbonate Solvents: Water ; pH 8, cooled
1.2 Reagents: Sodium carbonate Solvents: Water ; pH 8, cooled
Reference
- Process for the preparation of 2-chloro-1,8-naphthyridine derivatives, China, , ,
Production Method 5
Reaction Conditions
1.1 Reagents: Phosphorus oxychloride
Reference
- Potential antimalarials. I. 1,8-NaphthyridinesBarlin, Gordon B.; Tan, Weng Lai, Australian Journal of Chemistry, 1984, 37(5), 1065-73
2,5-Dichloro-1,8-naphthyridine Raw materials
2,5-Dichloro-1,8-naphthyridine Preparation Products
2,5-Dichloro-1,8-naphthyridine Related Literature
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Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
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Vitaly Gurylev,Chung-Yi Su,Tsong-Pyng Perng Phys. Chem. Chem. Phys., 2016,18, 16033-16038
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