- Quinoline derivatives as antibacterial agents and their preparation, pharmaceutical compositions and use in the treatment of bacterial infections, World Intellectual Property Organization, , ,
Cas no 918518-81-7 (3-Benzyl-7-bromo-2-chloroquinoline)
3-Benzyl-7-bromo-2-chloroquinoline is a halogenated quinoline derivative with a benzyl substituent at the 3-position, offering versatile reactivity for synthetic applications. The bromo and chloro functional groups at the 7- and 2-positions, respectively, provide selective sites for further modifications, making it a valuable intermediate in medicinal chemistry and material science. Its rigid quinoline core ensures stability, while the benzyl group enhances solubility in organic solvents, facilitating downstream reactions. This compound is particularly useful in cross-coupling reactions, heterocyclic synthesis, and as a building block for pharmaceuticals or agrochemicals. High purity and well-defined structure ensure reproducibility in research and industrial applications.
918518-81-7 structure
Product Name:3-Benzyl-7-bromo-2-chloroquinoline
CAS No:918518-81-7
MF:C16H11BrClN
MW:332.622242212296
MDL:MFCD21092049
CID:773916
PubChem ID:59200512
Update Time:2025-06-07
3-Benzyl-7-bromo-2-chloroquinoline Chemical and Physical Properties
Names and Identifiers
-
- Quinoline, 7-bromo-2-chloro-3-(phenylmethyl)-
- 3-benzyl-7-bromo-2-chloroquinoline
- 7-Bromo-2-chloro-3-(phenylmethyl)quinoline (ACI)
- AKOS015958901
- CS-15248
- SCHEMBL11982909
- CS-0011269
- 918518-81-7
- DB-099131
- C13206
- DTXSID40731245
- 3-Benzyl-7-bromo-2-chloroquinoline
-
- MDL： MFCD21092049
- Inchi： 1S/C16H11BrClN/c17-14-7-6-12-9-13(16(18)19-15(12)10-14)8-11-4-2-1-3-5-11/h1-7,9-10H,8H2
- InChI Key： YUQCGFZOLAXBGO-UHFFFAOYSA-N
- SMILES： ClC1C(CC2C=CC=CC=2)=CC2C(=CC(=CC=2)Br)N=1
Computed Properties
- Exact Mass: 330.97634g/mol
- Monoisotopic Mass: 330.97634g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 1
- Heavy Atom Count: 19
- Rotatable Bond Count: 2
- Complexity: 293
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 12.9
- XLogP3: 5.8
Experimental Properties
- Density: 1.5±0.1 g/cm3
- Boiling Point: 435.9±40.0 °C at 760 mmHg
- Flash Point: 217.4±27.3 °C
- Vapor Pressure: 0.0±1.0 mmHg at 25°C
3-Benzyl-7-bromo-2-chloroquinoline Security Information
- Signal Word：warning
- Hazard Statement： H303+H313+H333
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
3-Benzyl-7-bromo-2-chloroquinoline Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| eNovation Chemicals LLC | D769915-100mg |
Quinoline, 7-bromo-2-chloro-3-(phenylmethyl)- |
918518-81-7 | 98+% | 100mg |
$210 | 2024-06-07 | |
| eNovation Chemicals LLC | D769915-250mg |
Quinoline, 7-bromo-2-chloro-3-(phenylmethyl)- |
918518-81-7 | 98+% | 250mg |
$330 | 2024-06-07 | |
| eNovation Chemicals LLC | D769915-1g |
Quinoline, 7-bromo-2-chloro-3-(phenylmethyl)- |
918518-81-7 | 98+% | 1g |
$635 | 2024-06-07 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1066857-100mg |
3-Benzyl-7-bromo-2-chloroquinoline |
918518-81-7 | 98% | 100mg |
￥1649.00 | 2024-04-25 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1066857-250mg |
3-Benzyl-7-bromo-2-chloroquinoline |
918518-81-7 | 98% | 250mg |
￥3169.00 | 2024-04-25 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1066857-1g |
3-Benzyl-7-bromo-2-chloroquinoline |
918518-81-7 | 98% | 1g |
￥6327.00 | 2024-04-25 | |
| A2B Chem LLC | AD13114-1g |
Quinoline, 7-bromo-2-chloro-3-(phenylmethyl)- |
918518-81-7 | 98% | 1g |
$713.00 | 2024-07-18 | |
| eNovation Chemicals LLC | D769915-100mg |
Quinoline, 7-bromo-2-chloro-3-(phenylmethyl)- |
918518-81-7 | 98+% | 100mg |
$210 | 2025-02-25 | |
| eNovation Chemicals LLC | D769915-250mg |
Quinoline, 7-bromo-2-chloro-3-(phenylmethyl)- |
918518-81-7 | 98+% | 250mg |
$330 | 2025-02-25 | |
| eNovation Chemicals LLC | D769915-1g |
Quinoline, 7-bromo-2-chloro-3-(phenylmethyl)- |
918518-81-7 | 98+% | 1g |
$635 | 2025-02-25 |
3-Benzyl-7-bromo-2-chloroquinoline Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Phosphorus oxychloride Solvents: Phosphorus oxychloride ; 5 °C; 5 °C → rt
1.2 rt; 6 h, 85 °C; 85 °C → rt
1.2 rt; 6 h, 85 °C; 85 °C → rt
Reference
3-Benzyl-7-bromo-2-chloroquinoline Raw materials
3-Benzyl-7-bromo-2-chloroquinoline Preparation Products
3-Benzyl-7-bromo-2-chloroquinoline Related Literature
-
Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
-
Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
-
Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
-
Jason Wan Lab Chip, 2020,20, 4528-4538
-
M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
918518-81-7 (3-Benzyl-7-bromo-2-chloroquinoline) Related Products
- 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
- 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
- 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
- 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
- 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
- 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
- 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
- 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
- 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
- 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)
Recommended suppliers
Jinan Hanyu Chemical Co.,Ltd.
Gold Member
Audited Supplier
CN Supplier
Bulk
SunaTech Inc.
Gold Member
Audited Supplier
CN Supplier
Reagent
上海帛亦醫(yī)藥科技有限公司
Gold Member
Audited Supplier
CN Supplier
Reagent
Shanghai Bent Chemical Co., Ltd
Gold Member
Audited Supplier
CN Supplier
Bulk
Hangzhou Cedareal Technology Co., Ltd.
Gold Member
Audited Supplier
CN Supplier
Bulk
