• 1. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 2. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 3. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 4. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 5. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-halopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines 2-halopyridines

Comprehensive Overview of O-1-(6-chloropyridin-3-yl)ethylhydroxylamine (CAS No. 918311-18-9)

O-1-(6-chloropyridin-3-yl)ethylhydroxylamine (CAS No. 918311-18-9) is a specialized chemical compound with significant applications in pharmaceutical research and agrochemical development. This compound, characterized by its unique hydroxylamine functional group attached to a chloropyridinyl backbone, has garnered attention for its potential in intermediate synthesis and bioactive molecule design. Researchers and industry professionals frequently search for its synthetic pathways, physicochemical properties, and applications in drug discovery, making it a topic of interest in modern chemical innovation.

The structural features of O-1-(6-chloropyridin-3-yl)ethylhydroxylamine include a chlorine-substituted pyridine ring, which enhances its reactivity in nucleophilic substitution reactions. This property is particularly valuable in the development of crop protection agents and pharmaceutical intermediates. Recent trends in green chemistry have also sparked interest in optimizing its synthesis to reduce environmental impact, aligning with global demands for sustainable chemical processes. Common queries related to this compound include its solubility, stability under various conditions, and compatibility with other reagents.

In the context of drug discovery, O-1-(6-chloropyridin-3-yl)ethylhydroxylamine serves as a key building block for N-oxide derivatives, which are pivotal in enhancing the bioavailability of therapeutic compounds. Its role in catalysis and ligand design has been explored in peer-reviewed studies, addressing questions about its mechanistic pathways and potential side products. The compound’s molecular weight (C₇H₉ClN₂O) and spectroscopic data (e.g., NMR, IR) are frequently cited in analytical protocols, catering to laboratories focused on quality control and method validation.

Another emerging topic is the integration of O-1-(6-chloropyridin-3-yl)ethylhydroxylamine into high-throughput screening platforms. Its compatibility with automated synthesis systems and combinatorial chemistry workflows makes it a candidate for accelerating lead compound identification. Searches related to its scalability and cost-effective production reflect industry priorities, while academic inquiries often focus on its crystal structure and hydrogen bonding patterns.

From a regulatory perspective, the compound’s safety data and handling guidelines are critical for compliance with laboratory standards. Though not classified as hazardous, proper storage conditions (e.g., inert atmosphere, low temperature) are recommended to maintain its integrity. Discussions on patent literature and intellectual property surrounding its derivatives further highlight its commercial relevance.

In summary, O-1-(6-chloropyridin-3-yl)ethylhydroxylamine (CAS No. 918311-18-9) bridges fundamental research and industrial applications, addressing contemporary challenges in molecular design and process optimization. Its versatility ensures continued exploration across chemical, pharmaceutical, and agrochemical domains, supported by robust scientific inquiry and technological advancements.

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