Production Method 1

75-64-9

918-02-5

Reaction Conditions

1.1 Reagents: Water Catalysts: Gold (supported on alumina) ;  24 h, 112 °C

Reference

Water as Co-Hydrogen Donor in Reductive Aminations

Ke, Zhengang; Cui, Xinjiang; Shi, Feng, ACS Sustainable Chemistry & Engineering, 2016, 4(7), 3921-3926

Production Method 2

14610-37-8

918-02-5

Reaction Conditions

1.1 Reagents: Diphenylsilane Catalysts: 2254080-71-0 Solvents: Acetonitrile ;  24 h, 2.7 atm, 120 °C

Reference

Diverse catalytic reactivity of a dearomatized PN3P*-nickel hydride pincer complex towards CO2 reduction

Li, Huaifeng; Goncalves, Theo P.; Zhao, Qianyi; Gong, Dirong; Lai, Zhiping; et al, Chemical Communications (Cambridge, 2018, 54(81), 11395-11398

Production Method 3

75-64-9

918-02-5

Reaction Conditions

1.1 Catalysts: Bis(dichloro(η6-p-cymene)ruthenium) Solvents: Hexane ,  Water ;  5 h, 50 °C; 50 °C → rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  neutralized, rt

Reference

Ruthenium-Catalyzed Methylation of Amines with Paraformaldehyde in Water under Mild Conditions

van der Waals, Dominic; Heim, Leo. E.; Gedig, Christian; Herbrik, Fabian; Vallazza, Simona; et al, ChemSusChem, 2016, 9(17), 2343-2347

Production Method 4

21981-37-3

918-02-5

Reaction Conditions

Reference

Synthesis of N-methyldi-tert-butylamine: a highly hindered trialkylamine

Audeh, Costandi A.; Fuller, Steven E.; Hutchinson, Richard J.; Lindsay Smith, John R., Journal of Chemical Research, 1979, (8),

Production Method 5

75-64-9

918-02-5

14610-37-8

Reaction Conditions

1.1 Reagents: Formic acid

Reference

Application of statistical design to organic synthesis. Reductive alkylation of tert-butylamine (Leuckart Reaction)

Meiners, Alfred F.; Bolze, Calvin; Scherer, Alfred L.; Morriss, F. V., Journal of Organic Chemistry, 1958, 23, 1122-5

Production Method 6

75-64-9

918-02-5

Reaction Conditions

1.1 Catalysts: stereoisomer of [2-[Bis(1-methylethyl)phosphino-κP]-N-[2-[bis(1-methylethyl)phos… ;  24 h, 120 °C

Reference

Amination of Aliphatic Alcohols and Diols with an Iridium Pincer Catalyst

Andrushko, Natalia; Andrushko, Vasyl; Roose, Peter; Moonen, Kristof; Boerner, Armin, ChemCatChem, 2010, 2(6), 640-643

Production Method 7

75-64-9

918-02-5

Reaction Conditions

1.1 Reagents: Poly(methylhydrosiloxane) Catalysts: Tripotassium phosphate ,  18-Crown-6 Solvents: Acetonitrile ;  72 h, 1 atm, 80 °C

Reference

Scalable direct N-methylation of drug-like amines using 12CO2/13CO2 by simple inorganic base catalysis

Lu, Chunlei; Qiu, Zetian; Zhu, Yiling; Lin, Bo-Lin, Science Bulletin, 2019, 64(11), 723-729

Production Method 8

75-64-9

918-02-5

Reaction Conditions

1.1 Reagents: Zinc ,  Monosodium phosphate ,  Dipotassium phosphate Solvents: Water ;  20 h, 30 °C

Reference

Reductive methylation of primary and secondary amines and amino acids by aqueous formaldehyde and zinc

da Silva, Renato A.; Estevam, Idalia H. S.; Bieber, Lothar W., Tetrahedron Letters, 2007, 48(43), 7680-7682

Production Method 9

4981-48-0

918-02-5

Reaction Conditions

1.1 Solvents: Methanol ;  20 h, 100 °C; 100 °C → rt
1.2 Reagents: Potassium carbonate Catalysts: 2043953-31-5 Solvents: Methanol ;  36 h, 140 °C

Reference

Synthesis of N-methylated amines from acyl azides using methanol

Chakrabarti, Kaushik; Dutta, Kuheli; Kundu, Sabuj, Organic & Biomolecular Chemistry, 2020, 18(30), 5891-5896

Production Method 10

75-64-9

918-02-5

Reaction Conditions

1.1 Reagents: Hydrogen ;  1.0 MPa, 150 °C

Reference

Amination of aliphatic alcohols catalyzed by CuO-NiO/γ-Al2O3

Huang, Jia-min; Qian, Chao; Feng, Lie; Chen, Yun-bin; Chen, Xin-zhi, Monatshefte fuer Chemie, 2013, 144(8), 1187-1190

Production Method 11

918-02-5

Reaction Conditions

Reference

Reactions of alkylbenzyldimethylammonium halides with amide in liquid ammonia

Bumgardner, Carl L.; Hsu, Hon-Bin; Afghahi, F.; Roberts, William L.; Purrington, Suzanne T., Journal of Organic Chemistry, 1979, 44(14), 2348-53

N,N-Dimethyl-tert-butylamine Raw materials

• N-Methyl-tert-butylamine
• 2-Propanamine,N-(1,1-dimethylethyl)-2-methyl-
• Pivaloyl azide
• 2-methylpropan-2-amine

N,N-Dimethyl-tert-butylamine Preparation Products

• N-Methyl-tert-butylamine (14610-37-8)
• N,N-Dimethyl-tert-butylamine (918-02-5)

• 1. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
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• 2. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
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• 5. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Tertiary amines

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)