Production Method 1

90145-48-5

916314-03-9

Reaction Conditions

1.1 Reagents: Potassium(1+), (4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane-κN1,κ… Solvents: Dimethyl sulfoxide ;  20 min, 180 °C

Reference

Synthesis of fluorine-18-labeled 5- and 6-fluoro-2-pyridinamine

Abrahim, Aiman; et al, Journal of Labelled Compounds and Radiopharmaceuticals, 2006, 49(4), 345-356

Production Method 2

916314-04-0

916314-03-9

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Water ;  rt → 0 °C; 0 °C; 5 min, rt

Reference

Synthesis of fluorine-18-labeled 5- and 6-fluoro-2-pyridinamine

Abrahim, Aiman; et al, Journal of Labelled Compounds and Radiopharmaceuticals, 2006, 49(4), 345-356

Production Method 3

97483-77-7

916314-03-9

Reaction Conditions

1.1 Reagents: Potassium(1+), (4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane-κN1,κ… Solvents: Dimethyl sulfoxide ;  5 min, 150 °C
2.1 Reagents: Potassium hydroxide Solvents: Water ;  rt → 0 °C; 0 °C; 5 min, rt

Reference

Synthesis of fluorine-18-labeled 5- and 6-fluoro-2-pyridinamine

Abrahim, Aiman; et al, Journal of Labelled Compounds and Radiopharmaceuticals, 2006, 49(4), 345-356

5-Fluoro-2-pyridinecarboxamide Raw materials

• 5-Bromopyridine-2-carboxamide
• 5-Bromopicolinonitrile
• 5-(Fluoro-18F)-2-pyridinecarbonitrile

5-Fluoro-2-pyridinecarboxamide Preparation Products

• 5-Fluoro-2-pyridinecarboxamide (916314-03-9)

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