Production Method 1

115186-37-3

91550-08-2

Reaction Conditions

1.1 Solvents: Diethyl ether ;  0 °C; 1 h, 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Rh2(II)-Catalyzed Selective Aminomethylene Migration from Styryl Azides

Kong, Chen; et al, Organic Letters, 2013, 15(4), 824-827

Production Method 2

917-54-4

115186-37-3

91550-08-2

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Tetrahydrofuran ;  -78 °C; 2 h, -78 °C

Reference

An intramolecular Tsuji-Trost reaction based approach to the synthesis of 6-methylene indolizidines

Martin, Romy E.; et al, Tetrahedron Letters, 2011, 52(38), 4878-4881

Production Method 3

69610-41-9

91550-08-2

Reaction Conditions

1.1 Solvents: Tetrahydrofuran
1.2 Reagents: Ammonium chloride Solvents: Water
1.3 Reagents: Triethylamine ,  Sulfur trioxide-pyridine Solvents: Dimethyl sulfoxide

Reference

4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors

Wallen, Erik A. A.; et al, Bioorganic & Medicinal Chemistry, 2002, 10(7), 2199-2206

Production Method 4

91550-08-2

Reaction Conditions

Reference

Fragment-based synthesis and SAR of modified FKBP ligands: influence of different linking on binding affinity

Roehrig, Christoph H.; et al, ChemMedChem, 2007, 2(7), 1054-1070

Production Method 5

1117-97-1

15761-39-4

91550-08-2

Reaction Conditions

1.1 Reagents: 1-Hydroxybenzotriazole ,  Diisopropylethylamine ,  1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Solvents: Dimethylformamide ;  0 °C
2.1 Solvents: Tetrahydrofuran ;  -78 °C; 2 h, 0 °C
2.2 Reagents: Ammonium chloride Solvents: Water ;  0 °C

Reference

Peptidomimetic catalysts as chemical probes of weak intermolecular forces: an insight into The N-H···Cl-C H-bonding interaction

Iio, Chihiro; et al, ChemRxiv, 2023, 1, 1-17

Production Method 6

1117-97-1

15761-39-4

91550-08-2

Reaction Conditions

1.1 Solvents: Dimethylformamide ,  Dichloromethane ;  22 h, rt
2.1 Solvents: Tetrahydrofuran ;  4.5 h

Reference

Synthesis of N-Boc-L-2-acetylpiperidine and N-Boc-L-2-acetylpyrrolidine

Geng, Shu; et al, Huaxue Shiji, 2016, 38(5), 414-418

Production Method 7

676-58-4

115186-37-3

91550-08-2

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  4.5 h

Reference

Synthesis of N-Boc-L-2-acetylpiperidine and N-Boc-L-2-acetylpyrrolidine

Geng, Shu; et al, Huaxue Shiji, 2016, 38(5), 414-418

Production Method 8

676-58-4

115186-37-3

91550-08-2

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  -10 °C; 1 h, -10 °C; 16 h, rt

Reference

Studies on Pumiliotoxin A Alkaloids: An Approach to Preparing the Indolizidinic Core by Intramolecular Diastereoselective N-Heterocyclic Carbene Catalyzed Benzoin Reaction

Correia, Jose Tiago M.; et al, European Journal of Organic Chemistry, 2016, 2016(11), 1972-1976

Production Method 9

288086-98-6

91550-08-2

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  rt → -65 °C
1.2 Reagents: Butyllithium Solvents: Hexane ;  30 min, -65 °C
1.3 Solvents: Tetrahydrofuran ;  1 h, -60 °C; 3 h, -60 °C
1.4 Solvents: Water

Reference

Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors

Ferraris, Dana; et al, Bioorganic & Medicinal Chemistry Letters, 2004, 14(22), 5579-5583

Production Method 10

33857-76-0

917-54-4

91550-08-2

Reaction Conditions

1.1 Catalysts: Cuprous iodide Solvents: Diethyl ether ,  Tetrahydrofuran

Reference

α-Amino ketones derived from L-proline, as precursors for isomitosanes and mitosenes

Orlemans, E. O. M.; et al, Recueil des Travaux Chimiques des Pays-Bas, 1989, 108(2), 64-72

Production Method 11

15761-39-4

91550-08-2

Reaction Conditions

1.1 Reagents: Oxalyl chloride Solvents: Dimethylformamide ,  Pyridine
1.2 Reagents: Pyridine ,  N,O-Dimethylhydroxylamine hydrochloride
1.3 Solvents: Tetrahydrofuran

Reference

Stereoelectronic requirements of palladium(0)-catalyzed cyclization. A synthesis of allo-pumiliotoxin 339B

Trost, Barry M.; et al, Journal of the American Chemical Society, 1989, 111(13), 4988-90

Production Method 12

1117-97-1

15761-39-4

91550-08-2

Reaction Conditions

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane ;  15 min, rt; 15 h, rt
2.1 Solvents: Diethyl ether ;  0 °C; 1 h, 0 °C
2.2 Reagents: Ammonium chloride Solvents: Water

Reference

Rh2(II)-Catalyzed Selective Aminomethylene Migration from Styryl Azides

Kong, Chen; et al, Organic Letters, 2013, 15(4), 824-827

Production Method 13

15761-39-4

6638-79-5

91550-08-2

Reaction Conditions

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran ;  1 h, rt
1.2 Reagents: Triethylamine ;  overnight, rt
2.1 Solvents: Diethyl ether ;  0 °C; 1 h, 0 °C
2.2 Reagents: Ammonium chloride Solvents: Water

Reference

Efficient analysis of 2-acetyl-1-pyrroline in foods using a novel derivatization strategy and LC-MS/MS

Jost, Tobias ; et al, Journal of Agricultural and Food Chemistry, 2019, 67(10), 3046-3054

Tert-butyl (2S)-2-acetylpyrrolidine-1-carboxylate Raw materials

• 1-Pyrrolidinecarboxylic acid, 2-[(2-pyridinylthio)carbonyl]-, 1,1-dimethylethyl ester, (S)- (9CI)
• N,O-Dimethylhydroxylamine
• Boc-L-Pro-OH
• Methyllithium (1.6M in Diethyl Ether)
• Methylmagnesium Chloride (3M in THF)
• tert-butyl (2S)-2-formylpyrrolidine-1-carboxylate
• N,O-Dimethylhydroxylamine hydrochloride
• (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine
• tert-butyl (2S)-2-methoxy(methyl)carbamoylpyrrolidine-1-carboxylate

Tert-butyl (2S)-2-acetylpyrrolidine-1-carboxylate Preparation Products

• Tert-butyl (2S)-2-acetylpyrrolidine-1-carboxylate (91550-08-2)

• 1. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidine carboxylic acids and derivatives Pyrrolidine carboxylic acids

• 152533-47-6(Tert-Butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate)
• 675185-27-0(tert-butyl (2R)-2-acetylpyrrolidine-1-carboxylate)
• 187658-90-8(Tert-butyl 2-propionylpyrrolidine-1-carboxylate)
• 208037-77-8(8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester, (1R,5S)-)
• 1246661-06-2(1-Pyrrolidinecarboxylic acid, 2-(2-aminoacetyl)-, 1,1-dimethylethyl ester, (2S)-)
• 102284-42-4(1-Pyrrolidinecarboxylic acid, 2-[[(1-methylethyl)amino]acetyl]-,1,1-dimethylethyl ester, (S)-)
• 92012-22-1(tert-butyl 2-acetylpyrrolidine-1-carboxylate)
• 532410-54-1(1,4-Bis(N-tert-butoxycarbonyl-2-pyrrolidinyl)-1,4-butanedione)
• 100334-80-3(tert-Butyl (2S)-2-Propanoylpyrrolidine-1-carboxylate)
• 163513-98-2(tert-butyl (1R,4S)-2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate)