Production Method 1

138526-69-9

5570-18-3

915416-45-4

Reaction Conditions

1.1 Reagents: Tripotassium phosphate Catalysts: Hexadecachloro[μ8-[[5,11,17,23,29,35,41,47-octakis(phenylmethoxy)nonacyclo[43.3.… Solvents: Ethanol ;  2 h, 80 °C

Reference

Synthesis, Catalytic Activity and Comparative Leaching Studies of Calix[8]arene-Supported Pd-NHC Complexes for Suzuki-Miyaura Cross-Couplings

Abi Fayssal, Sandra; et al, Advanced Synthesis & Catalysis, 2022, 364(5), 947-957

Production Method 2

1056196-56-5

915416-45-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  4 h, 1.5 MPa, 60 °C

Reference

Efficient and Practical Synthesis of 3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine: A Key Intermediate of Fluxapyroxad

Li, Zhenhua ; et al, Organic Process Research & Development, 2019, 23(9), 1881-1886

Production Method 3

143418-49-9

915416-45-4

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Tetrahydrofuran ,  Water ;  16 h, 70 °C

Reference

Synthesis of Celecoxib, Mavacoxib, SC-560, Fluxapyroxad, and Bixafen Enabled by Continuous Flow Reaction Modules

Britton, Joshua; et al, European Journal of Organic Chemistry, 2017, 2017(44), 6566-6574

Production Method 4

143418-49-9

915416-45-4

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Dichlorobis(triphenylphosphine)palladium Solvents: 1,4-Dioxane ,  Water ;  3 h, 70 °C

Reference

A Detailed Study of Acetate-Assisted C-H Activation at Palladium(IV) Centers

Maleckis, Ansis; et al, Journal of the American Chemical Society, 2013, 135(17), 6618-6625

3',4',5'-Trifluoro-1,1'-biphenyl-2-amine Raw materials

• 3,4,5-Trifluorophenylboronic acid
• 3',4',5'-Trifluoro-2-nitrobiphenyl
• 1-Bromo-3,4,5-trifluorobenzene
• (2-Aminophenyl)boronic acid

3',4',5'-Trifluoro-1,1'-biphenyl-2-amine Preparation Products

• 3',4',5'-Trifluoro-1,1'-biphenyl-2-amine (915416-45-4)

• 1. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 2. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 3. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 4. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 5. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

Comprehensive Overview of 3',4',5'-Trifluoro-1,1'-biphenyl-2-amine (CAS No. 915416-45-4): Properties, Applications, and Industry Relevance

The compound 3',4',5'-Trifluoro-1,1'-biphenyl-2-amine (CAS No. 915416-45-4) is a fluorinated biphenyl derivative that has garnered significant attention in pharmaceutical and materials science research. With its unique trifluorinated aromatic structure, this compound serves as a versatile building block for synthesizing advanced molecules. The presence of fluorine atoms at the 3', 4', and 5' positions enhances its electronic properties, making it valuable for designing high-performance materials and bioactive compounds.

In recent years, the demand for fluorinated organic compounds has surged due to their applications in drug discovery and agrochemical development. Researchers are particularly interested in 3',4',5'-Trifluoro-1,1'-biphenyl-2-amine for its potential role in creating selective enzyme inhibitors and ligands for catalysis. Its structural rigidity and electron-withdrawing effects contribute to improved binding affinity in molecular interactions, a hot topic in medicinal chemistry discussions.

The synthesis of 915416-45-4 typically involves palladium-catalyzed cross-coupling reactions, a method widely explored in green chemistry initiatives. This aligns with the growing industry focus on sustainable synthesis routes, as evidenced by frequent searches for "eco-friendly fluorination methods" and "catalytic amination techniques". The compound’s thermal stability also makes it a candidate for electronic materials, addressing the need for heat-resistant polymers in semiconductor packaging.

Analytical characterization of 3',4',5'-Trifluoro-1,1'-biphenyl-2-amine relies on advanced techniques like NMR spectroscopy and high-resolution mass spectrometry, topics frequently queried in academic forums. Its solubility profile (moderate in polar aprotic solvents) is critical for formulation scientists, reflecting the popularity of searches such as "fluorinated amine solubility data". Regulatory databases confirm its compliance with major chemical inventories, ensuring global accessibility for research.

Future prospects for CAS No. 915416-45-4 include explorations in OLED materials and liquid crystal displays, areas where fluorinated aromatics excel. Industry reports highlight a compound annual growth rate (CAGR) of 8.2% for fluorine-based intermediates through 2030, underscoring the relevance of this chemical. As patent filings citing similar structures increase, 3',4',5'-Trifluoro-1,1'-biphenyl-2-amine remains a compound to watch in innovation-driven sectors.

• 188731-35-3(4-fluoro-2-(4-fluorophenyl)aniline)
• 873056-62-3(3',4'-Difluoro1,1'-biphenyl-2-amine)
• 873056-60-1(2-(3,5-Difluorophenyl)aniline)
• 321-63-1(4'-Fluoro-biphenyl-2-amine)
• 113600-23-0(Benzenamine, 4,5-difluoro-2-(1-pyrenyl)-)
• 147439-11-0([1,1'-Biphenyl]-2-amine, 2',3',4',5',6'-pentafluoro-)
• 139769-17-8([1,1'-Biphenyl]-2-amine, 5-fluoro-, hydrochloride)
• 139769-18-9(2-(3-Fluorophenyl)aniline Hydrochloride)
• 2264-92-8([1,1'-Biphenyl]-2-amine, 3'-fluoro-)
• 188731-36-4([1,1'-BIPHENYL]-2-AMINE, 5-FLUORO-4'-METHYL-)