- Efficient access to novel mono- and disubstituted pyrido[3,2-d]pyrimidinesTikad, Abdellatif; et al, Synlett, 2006, (12), 1938-1942
Cas no 915302-21-5 (Pyrido[3,2-d]pyrimidine, 2-chloro-)
![Pyrido[3,2-d]pyrimidine, 2-chloro- structure](https://ossimg.kuujia.com/scimg/915500/915302-21-5x500.png)
915302-21-5 structure
Product Name:Pyrido[3,2-d]pyrimidine, 2-chloro-
CAS No:915302-21-5
MF:C7H4ClN3
MW:165.579759597778
MDL:MFCD13189444
CID:4311728
PubChem ID:11958054
Update Time:2024-10-26
Pyrido[3,2-d]pyrimidine, 2-chloro- Chemical and Physical Properties
Names and Identifiers
-
- Pyrido[3,2-d]pyrimidine, 2-chloro-
- 2-Chloro-pyrido[3,2-d]pyrimidine
- 2-Chloropyrido[3,2-d]pyrimidine (ACI)
- MFCD13189444
- 2-Chloropyrido[3,2-d]pyrimidine
- SY358399
- PB28512
- 2-Chloro-pyrido[3,2-d]pyrimidine-C12288
- E76687
- BS-51072
- 915302-21-5
- LEIGIRAWJADGAI-UHFFFAOYSA-N
- SCHEMBL2269742
- chloropyridopyrimidine
- CS-0187912
-
- MDL： MFCD13189444
- Inchi： 1S/C7H4ClN3/c8-7-10-4-6-5(11-7)2-1-3-9-6/h1-4H
- InChI Key： LEIGIRAWJADGAI-UHFFFAOYSA-N
- SMILES： ClC1N=C2C(N=CC=C2)=CN=1
Computed Properties
- Exact Mass: 165.0093748g/mol
- Monoisotopic Mass: 165.0093748g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 11
- Rotatable Bond Count: 0
- Complexity: 142
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 1.5
- Topological Polar Surface Area: 38.7?2
Experimental Properties
- Density: 1.4±0.1 g/cm3
- Melting Point: Not available
- Boiling Point: Not available
- Flash Point: Not available
- Vapor Pressure: Not available
Pyrido[3,2-d]pyrimidine, 2-chloro- Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - Safety Instruction： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
Pyrido[3,2-d]pyrimidine, 2-chloro- Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Matrix Scientific | 122845-1g |
2-Chloro-pyrido[3,2-d]pyrimidine, 95+% |
915302-21-5 | 95+% | 1g |
$2492.00 | 2023-09-06 | |
| Chemenu | CM529349-50mg |
2-Chloropyrido[3,2-d]pyrimidine |
915302-21-5 | 97% | 50mg |
$82 | 2024-07-20 | |
| Chemenu | CM529349-100mg |
2-Chloropyrido[3,2-d]pyrimidine |
915302-21-5 | 97% | 100mg |
$155 | 2024-07-20 | |
| Chemenu | CM529349-250mg |
2-Chloropyrido[3,2-d]pyrimidine |
915302-21-5 | 97% | 250mg |
$356 | 2024-07-20 | |
| Chemenu | CM529349-1g |
2-Chloropyrido[3,2-d]pyrimidine |
915302-21-5 | 97% | 1g |
$1069 | 2024-07-20 | |
| eNovation Chemicals LLC | Y1106690-1g |
2-chloropyrido[3,2-d]pyrimidine |
915302-21-5 | 95% | 1g |
$1500 | 2024-07-23 | |
| Ambeed | A787023-25mg |
2-Chloropyrido[3,2-d]pyrimidine |
915302-21-5 | 97% | 25mg |
$67.0 | 2024-08-02 | |
| Ambeed | A787023-50mg |
2-Chloropyrido[3,2-d]pyrimidine |
915302-21-5 | 97% | 50mg |
$81.0 | 2024-08-02 | |
| Ambeed | A787023-100mg |
2-Chloropyrido[3,2-d]pyrimidine |
915302-21-5 | 97% | 100mg |
$98.0 | 2024-08-02 | |
| Ambeed | A787023-250mg |
2-Chloropyrido[3,2-d]pyrimidine |
915302-21-5 | 97% | 250mg |
$239.0 | 2024-08-02 |
Pyrido[3,2-d]pyrimidine, 2-chloro- Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Tributylstannane Solvents: Toluene ; 30 min, rt
1.2 Catalysts: Tetrakis(triphenylphosphine)palladium ; 1 h, 100 °C; 100 °C → rt
1.3 Reagents: Potassium fluoride Solvents: Water ; rt
1.2 Catalysts: Tetrakis(triphenylphosphine)palladium ; 1 h, 100 °C; 100 °C → rt
1.3 Reagents: Potassium fluoride Solvents: Water ; rt
Reference
Production Method 2
Reaction Conditions
Reference
- Efficient synthesis of 2-substituted pyrido[3,2-d]pyrimidines involving SNAr and palladium-catalyzed cross-coupling reactionsTikad, Abdellatif; et al, Synthesis, 2009, (14), 2379-2384
Production Method 3
Reaction Conditions
1.1 Reagents: Pyridine Solvents: Toluene ; 24 h, reflux
2.1 Reagents: Aluminum chloride Solvents: Anisole ; 2 h, rt
3.1 Reagents: Phosphorus oxychloride , Phosphorus pentachloride ; 4 h, reflux
4.1 Reagents: Tributylstannane Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene ; 1 h, 100 °C
2.1 Reagents: Aluminum chloride Solvents: Anisole ; 2 h, rt
3.1 Reagents: Phosphorus oxychloride , Phosphorus pentachloride ; 4 h, reflux
4.1 Reagents: Tributylstannane Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene ; 1 h, 100 °C
Reference
- New synthesis method and reactivity of 2,4-dichloro- and 4-chloropyrido[3,2-d]pyrimidinesTikad, Abdellatif; et al, Studii si Cercetari Stiintifice: Chimie si Inginerie Chimica, 2006, 7(1), 55-58
Production Method 4
Reaction Conditions
1.1 Reagents: Phosphorus pentachloride Solvents: Phosphorus oxychloride ; 4 h, reflux; reflux → rt
1.2 Reagents: Sodium carbonate Solvents: Water ; neutralized, rt
2.1 Reagents: Tributylstannane Solvents: Toluene ; 30 min, rt
2.2 Catalysts: Tetrakis(triphenylphosphine)palladium ; 1 h, 100 °C; 100 °C → rt
2.3 Reagents: Potassium fluoride Solvents: Water ; rt
1.2 Reagents: Sodium carbonate Solvents: Water ; neutralized, rt
2.1 Reagents: Tributylstannane Solvents: Toluene ; 30 min, rt
2.2 Catalysts: Tetrakis(triphenylphosphine)palladium ; 1 h, 100 °C; 100 °C → rt
2.3 Reagents: Potassium fluoride Solvents: Water ; rt
Reference
- Efficient access to novel mono- and disubstituted pyrido[3,2-d]pyrimidinesTikad, Abdellatif; et al, Synlett, 2006, (12), 1938-1942
Production Method 5
Reaction Conditions
1.1 Reagents: Aluminum chloride Solvents: Anisole ; 2 h, rt
2.1 Reagents: Phosphorus pentachloride Solvents: Phosphorus oxychloride ; 4 h, reflux; reflux → rt
2.2 Reagents: Sodium carbonate Solvents: Water ; neutralized, rt
3.1 Reagents: Tributylstannane Solvents: Toluene ; 30 min, rt
3.2 Catalysts: Tetrakis(triphenylphosphine)palladium ; 1 h, 100 °C; 100 °C → rt
3.3 Reagents: Potassium fluoride Solvents: Water ; rt
2.1 Reagents: Phosphorus pentachloride Solvents: Phosphorus oxychloride ; 4 h, reflux; reflux → rt
2.2 Reagents: Sodium carbonate Solvents: Water ; neutralized, rt
3.1 Reagents: Tributylstannane Solvents: Toluene ; 30 min, rt
3.2 Catalysts: Tetrakis(triphenylphosphine)palladium ; 1 h, 100 °C; 100 °C → rt
3.3 Reagents: Potassium fluoride Solvents: Water ; rt
Reference
- Efficient access to novel mono- and disubstituted pyrido[3,2-d]pyrimidinesTikad, Abdellatif; et al, Synlett, 2006, (12), 1938-1942
Production Method 6
Reaction Conditions
1.1 Reagents: Aluminum chloride Solvents: Anisole ; 2 h, rt
2.1 Reagents: Phosphorus oxychloride , Phosphorus pentachloride ; 4 h, reflux
3.1 Reagents: Tributylstannane Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene ; 1 h, 100 °C
2.1 Reagents: Phosphorus oxychloride , Phosphorus pentachloride ; 4 h, reflux
3.1 Reagents: Tributylstannane Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene ; 1 h, 100 °C
Reference
- New synthesis method and reactivity of 2,4-dichloro- and 4-chloropyrido[3,2-d]pyrimidinesTikad, Abdellatif; et al, Studii si Cercetari Stiintifice: Chimie si Inginerie Chimica, 2006, 7(1), 55-58
Production Method 7
Reaction Conditions
1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran ; rt → -10 °C
1.2 Reagents: Ethyl chloroformate ; 1.5 h, -10 °C
1.3 Reagents: Sodium azide Solvents: Water ; 1.5 h, 0 °C
1.4 Solvents: Toluene ; 2 h, reflux; reflux → rt
1.5 Solvents: Pyridine ; 24 h, reflux
2.1 Reagents: Aluminum chloride Solvents: Anisole ; 2 h, rt
3.1 Reagents: Phosphorus pentachloride Solvents: Phosphorus oxychloride ; 4 h, reflux; reflux → rt
3.2 Reagents: Sodium carbonate Solvents: Water ; neutralized, rt
4.1 Reagents: Tributylstannane Solvents: Toluene ; 30 min, rt
4.2 Catalysts: Tetrakis(triphenylphosphine)palladium ; 1 h, 100 °C; 100 °C → rt
4.3 Reagents: Potassium fluoride Solvents: Water ; rt
1.2 Reagents: Ethyl chloroformate ; 1.5 h, -10 °C
1.3 Reagents: Sodium azide Solvents: Water ; 1.5 h, 0 °C
1.4 Solvents: Toluene ; 2 h, reflux; reflux → rt
1.5 Solvents: Pyridine ; 24 h, reflux
2.1 Reagents: Aluminum chloride Solvents: Anisole ; 2 h, rt
3.1 Reagents: Phosphorus pentachloride Solvents: Phosphorus oxychloride ; 4 h, reflux; reflux → rt
3.2 Reagents: Sodium carbonate Solvents: Water ; neutralized, rt
4.1 Reagents: Tributylstannane Solvents: Toluene ; 30 min, rt
4.2 Catalysts: Tetrakis(triphenylphosphine)palladium ; 1 h, 100 °C; 100 °C → rt
4.3 Reagents: Potassium fluoride Solvents: Water ; rt
Reference
- Efficient access to novel mono- and disubstituted pyrido[3,2-d]pyrimidinesTikad, Abdellatif; et al, Synlett, 2006, (12), 1938-1942
Production Method 8
Reaction Conditions
1.1 Reagents: Triethylamine , Ethyl chloroformate ; 1.5 h, -10 °C
1.2 Reagents: Sodium azide Solvents: Water ; 1.5 h, -10 °C → 0 °C
1.3 Solvents: Toluene ; 2 h, reflux
2.1 Reagents: Pyridine Solvents: Toluene ; 24 h, reflux
3.1 Reagents: Aluminum chloride Solvents: Anisole ; 2 h, rt
4.1 Reagents: Phosphorus oxychloride , Phosphorus pentachloride ; 4 h, reflux
5.1 Reagents: Tributylstannane Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene ; 1 h, 100 °C
1.2 Reagents: Sodium azide Solvents: Water ; 1.5 h, -10 °C → 0 °C
1.3 Solvents: Toluene ; 2 h, reflux
2.1 Reagents: Pyridine Solvents: Toluene ; 24 h, reflux
3.1 Reagents: Aluminum chloride Solvents: Anisole ; 2 h, rt
4.1 Reagents: Phosphorus oxychloride , Phosphorus pentachloride ; 4 h, reflux
5.1 Reagents: Tributylstannane Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene ; 1 h, 100 °C
Reference
- New synthesis method and reactivity of 2,4-dichloro- and 4-chloropyrido[3,2-d]pyrimidinesTikad, Abdellatif; et al, Studii si Cercetari Stiintifice: Chimie si Inginerie Chimica, 2006, 7(1), 55-58
Pyrido[3,2-d]pyrimidine, 2-chloro- Raw materials
- (4-methoxyphenyl)methanamine
- 2,4-Dichloropyrido[3,2-D]pyrimidine
- 3-(4-methoxyphenyl)methyl-1H,2H,3H,4H-pyrido3,2-dpyrimidine-2,4-dione
- 2-(methoxycarbonyl)pyridine-3-carboxylic acid
- 3-isocyanato-2-Pyridinecarboxylic acid methyl ester
- 1H-pyrido[3,2-d]pyrimidine-2,4-dione
Pyrido[3,2-d]pyrimidine, 2-chloro- Preparation Products
Pyrido[3,2-d]pyrimidine, 2-chloro- Related Literature
-
Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
-
Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
-
Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
-
Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
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