• 1. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 2. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 3. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 4. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 5. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinoline carboxylic acids

Recent Advances in the Application of 8-Fluoroquinoline-2-carboxylic acid (CAS: 914208-13-2) in Chemical Biology and Pharmaceutical Research

The compound 8-Fluoroquinoline-2-carboxylic acid (CAS: 914208-13-2) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications in drug discovery and development. This heterocyclic compound, characterized by a quinoline backbone with a fluorine substituent at the 8-position and a carboxylic acid group at the 2-position, exhibits unique physicochemical properties that make it a valuable scaffold for designing novel therapeutic agents. Recent studies have explored its potential as a building block for antimicrobial, anticancer, and anti-inflammatory agents, leveraging its ability to interact with various biological targets.

One of the most notable advancements in the application of 8-Fluoroquinoline-2-carboxylic acid is its role in the development of antimicrobial agents. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit potent activity against multidrug-resistant bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. The researchers attributed this activity to the compound's ability to inhibit bacterial DNA gyrase and topoisomerase IV, key enzymes involved in DNA replication. The fluorine substituent was found to enhance the compound's binding affinity to these enzymes, while the carboxylic acid group facilitated solubility and bioavailability.

In the realm of anticancer research, 8-Fluoroquinoline-2-carboxylic acid has been investigated as a precursor for the synthesis of kinase inhibitors. A recent study in Bioorganic & Medicinal Chemistry Letters highlighted its utility in designing selective inhibitors of the epidermal growth factor receptor (EGFR), a target of significant interest in oncology. The study reported that modifications to the quinoline core, particularly at the 2-carboxylic acid position, yielded compounds with improved potency and selectivity against EGFR mutant forms commonly found in non-small cell lung cancer (NSCLC). These findings underscore the compound's potential as a versatile scaffold for targeted cancer therapies.

Beyond its antimicrobial and anticancer applications, 8-Fluoroquinoline-2-carboxylic acid has also shown promise in the development of anti-inflammatory agents. A 2024 study published in European Journal of Medicinal Chemistry explored its derivatives as inhibitors of cyclooxygenase-2 (COX-2), an enzyme implicated in inflammatory diseases such as rheumatoid arthritis and osteoarthritis. The researchers found that the fluorine atom at the 8-position played a critical role in enhancing the compound's binding to the COX-2 active site, while the carboxylic acid group contributed to its anti-inflammatory efficacy. These results suggest that further optimization of this scaffold could lead to the development of novel anti-inflammatory drugs with improved safety profiles.

The synthesis and characterization of 8-Fluoroquinoline-2-carboxylic acid have also been the subject of recent research. Advanced spectroscopic techniques, including nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS), have been employed to confirm the compound's structure and purity. Additionally, computational modeling studies have provided insights into its molecular interactions with biological targets, facilitating the rational design of derivatives with enhanced pharmacological properties. These methodological advancements have significantly contributed to the compound's growing prominence in drug discovery pipelines.

In conclusion, 8-Fluoroquinoline-2-carboxylic acid (CAS: 914208-13-2) represents a highly versatile and promising scaffold in chemical biology and pharmaceutical research. Its applications span antimicrobial, anticancer, and anti-inflammatory therapies, with recent studies highlighting its potential to address unmet medical needs. Continued research into its derivatives and mechanisms of action is expected to yield further breakthroughs, solidifying its role as a key player in the development of next-generation therapeutics. As the field progresses, interdisciplinary collaborations between chemists, biologists, and pharmacologists will be essential to fully unlock the compound's potential.

• 3093-97-8(6-Fluoro-1H-indole-2-carboxylic acid)
• 920985-68-8(2-Quinolinecarboxylic acid, 5,8-difluoro-)
• 511234-64-3(5-fluoroquinoline-2-carboxylic acid)
• 399-76-8(5-fluoro-1H-indole-2-carboxylic acid)
• 834884-09-2(2-Quinolinecarboxylic acid, 3,7-difluoro-)
• 834884-07-0(2-Quinolinecarboxylic acid, 3-fluoro-)
• 86324-51-8(6-Fluoroquinoline-2-carboxylic acid)
• 186432-20-2(5,7-Difluoro-1H-indole-2-carboxylic acid)
• 256929-92-7(7-fluoroquinoline-2-carboxylic acid)
• 399-67-7(7-Fluoro-1H-indole-2-carboxylic acid)