Production Method 1

91407-40-8

91407-41-9

347-54-6

Reaction Conditions

1.1 Reagents: Ammonium thiocyanate ,  Oxygen Catalysts: Sodium fluorescein Solvents: Acetonitrile ;  10 h, rt

Reference

Thiocyanate radical mediated dehydration of aldoximes with visible light and air

Ban, Yong-Liang; et al, Chemical Communications (Cambridge, 2019, 55(65), 9701-9704

Production Method 2

371-41-5

91407-41-9

Reaction Conditions

1.1 Reagents: Triethylamine ,  Magnesium chloride Solvents: Tetrahydrofuran ;  rt → reflux; 2 - 4 h, reflux; cooled
1.2 Reagents: Ammonia Solvents: Methanol ,  Water ;  30 min
1.3 Reagents: 2-Iodoxybenzoic acid ;  2 - 10 h

Reference

A one-pot synthesis of substituted salicylnitriles

Anwar, Hany F.; et al, Tetrahedron Letters, 2008, 49(28), 4443-4445

Production Method 3

189628-38-4

91407-41-9

Reaction Conditions

1.1 Reagents: Lithium chloride Solvents: Dimethyl sulfoxide ;  6 h, 155 °C

Reference

A Catalytic Route to Ampakines and Their Derivatives

Mulzer, Michael; et al, Organic Letters, 2011, 13(6), 1426-1428

Production Method 4

347-54-6

91407-41-9

347-54-6

Reaction Conditions

1.1 Reagents: Sodium acetate ,  Hydroxyamine hydrochloride Solvents: Ethanol ,  Water ;  30 min, rt
1.2 1 h, rt → reflux
2.1 Reagents: Ammonium thiocyanate ,  Oxygen Catalysts: Sodium fluorescein Solvents: Acetonitrile ;  10 h, rt

Reference

Thiocyanate radical mediated dehydration of aldoximes with visible light and air

Ban, Yong-Liang; et al, Chemical Communications (Cambridge, 2019, 55(65), 9701-9704

5-Fluoro-2-hydroxybenzonitrile Raw materials

• 5-Fluorosalicylaldehyde
• 5-Fluoro-2-methoxybenzonitrile
• 4-Fluoro-2-(1E)-(hydroxyimino)methylphenol
• 4-Fluorophenol

5-Fluoro-2-hydroxybenzonitrile Preparation Products

• 5-Fluorosalicylaldehyde (347-54-6)
• 5-Fluoro-2-hydroxybenzonitrile (91407-41-9)

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• 140675-43-0(2-Fluoro-6-hydroxybenzonitrile)
• 189628-38-4(5-Fluoro-2-methoxybenzonitrile)
• 357404-55-8(Benzonitrile,5-fluoro-2-hydroxy-4-methyl-)
• 186590-36-3(4,5-Difluoro-2-hydroxybenzonitrile)
• 186590-34-1(3,4-Difluoro-2-hydroxybenzonitrile)
• 186590-01-2(4-Fluoro-2-hydroxybenzonitrile)
• 186590-11-4(Benzonitrile,4-fluoro-2,5-dihydroxy-)
• 862088-17-3(3,5-Difluoro-2-hydroxybenzonitrile)
• 28177-74-4(3-Fluoro-2-hydroxybenzonitrile)
• 606489-70-7