Production Method 1

91147-07-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium ,  Carbon Solvents: Methanol

Reference

β-Carboline alkaloids. Part 6. Total synthesis of the phosphodiesterase inhibitor infractine

Bracher, F.; Hildebrand, D., Pharmazie, 1995, 50(3), 182-3

Production Method 2

91147-07-8

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ;  24 h, reflux; reflux → rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 8

Reference

Synthesis of Alkyl-Substituted Pyridines by Directed Pd(II)-Catalyzed C-H Activation of Alkanoic Amides

Hu, Peng; Bach, Thorsten, Synlett, 2015, 26(20), 2853-2857

Production Method 3

91147-07-8

Reaction Conditions

Reference

Synthesis of manzamine C, infractine and 6-hydroxyinfractine

Nowak, Wolfgang; Gerlach, Hans, Liebigs Annalen der Chemie, 1993, (2), 153-9

Production Method 4

92870-51-4

91147-07-8

Reaction Conditions

1.1 Reagents: 2-Chloropyridine ,  Trifluoromethanesulfonic anhydride Solvents: Dichloromethane ;  1 min, -78 °C; 5 min, -78 °C; 5 min, -78 °C → 0 °C; 0 °C → rt; 3 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Solution Phase and Nanoparticular Biosynthetically Inspired Interconnections in the Canthin-6-one β-Carboline Series and Study of Phenotypic Properties on C. elegans

Cebrian-Torrejon, Gerardo; Mackiewicz, Nicolas; Vazquez-Manrique, Rafael P.; Fournet, Alain; Figadere, Bruno; et al, European Journal of Organic Chemistry, 2013, 2013(26), 5821-5828

methyl 3-(9H-beta-carbolin-1-yl)propanoate Raw materials

• N-(2-Indol-3-ylethyl)-succinamic Acid Methyl Ester

methyl 3-(9H-beta-carbolin-1-yl)propanoate Preparation Products

• methyl 3-(9H-beta-carbolin-1-yl)propanoate (91147-07-8)

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• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives Harmala alkaloids Harmala alkaloids
• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives Harmala alkaloids

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• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
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• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
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