Production Method 1

19752-55-7

91085-56-2

Reaction Conditions

1.1 Reagents: Benzyltriphenylphosphonium chloride Catalysts: Bis(tri-tert-butylphosphine)palladium Solvents: Toluene ;  24 h, 20 atm, rt → 110 °C
1.2 Reagents: 4-(Dimethylamino)pyridine Solvents: Toluene ;  rt; 2 h, rt
1.3 Solvents: Ethanol ;  2 h, rt

Reference

Acid chloride synthesis by the palladium-catalyzed chlorocarbonylation of aryl bromides

Quesnel, Jeffrey S.; Kayser, Laure V.; Fabrikant, Alexander; Arndtsen, Bruce A., Chemistry - A European Journal, 2015, 21(26), 9550-9555

Production Method 2

51-36-5

91085-56-2

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water

Reference

Synthesis of trans- methyl ferulate bearing an oxadiazole ether as potential activators for controlling plant virus

He, Feng; Wei, Panpan; Yu, Gang; Guo, Shengxin; Zheng, Zhiguo; et al, Bioorganic Chemistry, 2021, 115,

Production Method 3

51-36-5

91085-56-2

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  reflux

Reference

4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors

Gavara, Laurent; Sevaille, Laurent; De Luca, Filomena; Mercuri, Paola; Bebrone, Carine ; et al, European Journal of Medicinal Chemistry, 2020, 208,

Production Method 4

51-36-5

91085-56-2

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  7 h, reflux

Reference

Synthesis of novel indole derivatives containing double 1,3,4-oxadiazole moiety as efficient bactericides against phytopathogenic bacterium Xanthomonas oryzae

Tian, Kun; Li, Xiao-Qin; Zhang, Li; Gan, Yi-Yuan; Meng, Jiao; et al, Chemical Papers, 2019, 73(1), 17-25

Production Method 5

51-36-5

91085-56-2

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Ethanol ;  10 h, rt → reflux

Reference

Synthesis, characterization and antimicrobial evaluation of novel (E)-N'-(4-(1-((3,4-dimethoxypyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)benzylidene)benzohydrazide derivatives

Saidugari, Swamy; Vadali, Lakshmana Rao; Vidya, K.; Ram, B., Oriental Journal of Chemistry, 2016, 32(4), 2155-2161

Production Method 6

51-36-5

91085-56-2

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethanol ;  reflux

Reference

Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety

Xu, F. Z.; Wang, Y. Y.; Luo, D. X.; Yu, G.; Guo, S. X.; et al, RSC Advances, 2018, 8(12), 6306-6314

Production Method 7

51-36-5

91085-56-2

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Ethanol ;  10 - 12 h, reflux

Reference

Synthesis and anti-inflammatory activity of hydrazones bearing biphenyl moiety and vanillin based hybrids

Reddy, A. L. V. Kumar; Kathale, Niren E., Oriental Journal of Chemistry, 2017, 33(2), 971-978

Production Method 8

51-36-5

91085-56-2

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  reflux

Reference

Synthesis and bioactivity of sulfide derivatives containing 1,3,4-oxadiazole and pyridine

Yu, Gang; Chen, Shunhong; He, Feng; Luo, Dexia; Zhang, Yu; et al, Turkish Journal of Chemistry, 2019, 43(4), 1075-1085

Production Method 9

51-36-5

91085-56-2

Reaction Conditions

Reference

Reductive carboxylation of aromatic esters by electron transfer from magnesium metal

Maekawa, Hirofumi; Okawara, Hikaru; Murakami, Taro, Tetrahedron Letters, 2017, 58(3), 206-209

Production Method 10

51-36-5

91085-56-2

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Ethanol ;  10 h, reflux

Reference

Synthesis and antibacterial activity of some new quinoxaline-benzohydrazides

Haripriya, V.; Laxminarayana, E.; Chary, M. Thirumala, Indian Journal of Chemistry, 2016, (2), 207-212

Production Method 11

51-36-5

91085-56-2

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethanol ;  6 - 10 h, rt → reflux

Reference

Synthesis and antimicrobial activity of new imidazole-hydrazone derivatives

Prasanna, V. Laxmi; Narender, R., Asian Journal of Chemistry, 2015, 27(10), 3605-3608

Ethyl 3,5-dichlorobenzoate Raw materials

• 3,5-Dichlorobenzoic acid
• 1-Bromo-3,5-dichlorobenzene

Ethyl 3,5-dichlorobenzoate Preparation Products

• Ethyl 3,5-dichlorobenzoate (91085-56-2)

• 1. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 2. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 3. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 4. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

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• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
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