Production Method 1

2142-69-0

91054-33-0

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Oxygen Catalysts: Nickel ferrite Solvents: Dimethylformamide ;  70 h, 100 °C

Reference

Highly active recyclable heterogeneous nanonickel ferrite catalyst for cyanation of aryl and heteroaryl halides

Matloubi Moghaddam, Firouz; Tavakoli, Ghazal; Rezvani, Hamid Reza, Applied Organometallic Chemistry, 2014, 28(10), 750-755

Production Method 2

7188-38-7

2142-70-3

91054-33-0

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Catalysts: Tricyclohexylphosphine ,  Manganese ,  Nickel bromide Solvents: Toluene ;  22 h, 150 °C

Reference

Nickel-catalyzed cyanation reaction of aryl/alkenyl halides with alkyl isocyanides

Zhang, Yanling; Zhang, Zhiguo; Hu, Yuanyuan; Liu, Yunkui; Jin, Hongwei; et al, Organic & Biomolecular Chemistry, 2022, 20(41), 8049-8053

Production Method 3

13943-58-3

2142-69-0

91054-33-0

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Diethyl azodicarboxylate Catalysts: Bis[2-[[bis(phenylmethyl)amino-κN]methyl]phenyl-κC]di-μ-bromodipalladium Solvents: Dimethylformamide ;  1 min, 130 °C; 20 min, 130 °C; 130 °C → rt

Reference

Microwave-enhanced synthesis of aryl nitriles using dimeric orthopalladated complex of tribenzylamine and K4[Fe(CN)6]

Hajipour, Abdol Reza; Rafiee, Fatemeh; Ruoho, Arnold E., Tetrahedron Letters, 2012, 53(5), 526-529

Production Method 4

551-93-9

91054-33-0

Reaction Conditions

1.1 Reagents: Acetic acid ,  Hydrochloric acid Solvents: Water ;  rt; 5 min, reflux; reflux → 0 °C
1.2 Reagents: Sodium nitrite Solvents: Water ;  0 °C; 0 °C → rt; 2 h, rt
1.3 Reagents: Cuprous cyanide Solvents: Toluene ,  Water ;  rt; 1 h, 65 °C; 2 h, rt

Reference

Highly Stereoselective Chemoenzymatic Synthesis of the 3H-Isobenzofuran Skeleton. Access to Enantiopure 3-Methylphthalides

Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente, Organic Letters, 2012, 14(6), 1444-1447

Production Method 5

13943-58-3

2142-69-0

91054-33-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Palladium(1+), [2-[(amino-κN)methyl]phenyl-κC][1-(4-methoxyphenyl)-2-(triphenylp… Solvents: Dimethylformamide ;  30 min, 130 °C; 130 °C → rt

Reference

An efficient palladium catalytic system for microwave assisted cyanation of aryl halides

Hajipour, Abdol R.; Karami, Kazem; Tavakoli, Ghazal; Pirisedigh, Azade, Journal of Organometallic Chemistry, 2011, 696(4), 819-824

Production Method 6

138642-62-3

91054-33-0

Reaction Conditions

1.1 Reagents: Cesium carbonate Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene ;  24 h, 100 °C

Reference

Synthesis and organocatalytic asymmetric nitro-aldol initiated cascade reactions of 2-acylbenzonitriles leading to 3,3-disubstituted isoindolinones

Romano, Fabio; Di Mola, Antonia; Palombi, Laura; Tiffner, Maximilian; Waser, Mario; et al, Catalysts, 2019, 9(4), 327/1-327/11

Production Method 7

551-93-9

91054-33-0

Reaction Conditions

1.1 Reagents: Copper ,  Sulfuric acid ,  Copper sulfate Solvents: Water ;  2 h, reflux
1.2 Reagents: Sodium nitrite Solvents: Water ;  80 - 90 °C

Reference

Candida tenuis xylose reductase catalyzed reduction of acetophenones: the effect of ring-substituents on catalytic efficiency

Vogl, Michael; Kratzer, Regina; Nidetzky, Bernd; Brecker, Lothar, Organic & Biomolecular Chemistry, 2011, 9(16), 5863-5870

Production Method 8

91054-33-0

Reaction Conditions

Reference

Direct formation of organocopper compounds by oxidative addition of zerovalent copper to organic halides

Ebert, Greg; Rieke, Reuben D., Journal of Organic Chemistry, 1984, 49(26), 5280-2

Production Method 9

4387-36-4

6213-94-1

91054-33-0

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: Triphenylphosphine ,  Palladium diacetate Solvents: Dimethyl sulfoxide ,  Dimethylformamide ;  rt; 2 h, 100 °C

Reference

Microwave-assisted one-step synthesis of acetophenones via palladium-catalyzed regioselective arylation of vinyloxytrimethylsilane

Qian, Wangke; Zhang, Lei; Sun, Haifeng; Jiang, Hualiang; Liu, Hong, Advanced Synthesis & Catalysis, 2012, 354(17), 3231-3236

Production Method 10

34136-59-9

91054-33-0

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Acetonitrile ,  Water ;  3.5 h, 80 °C

Reference

Synthesis of 2-Acetylbenzonitriles and Their Reactivity in Tandem Reactions with Carbon and Hetero Nucleophiles: Easy Access to 3,3-Disubstituted Isoindolinones

Di Mola, Antonia; Di Martino, Miriam; Capaccio, Vito; Pierri, Giovanni; Palombi, Laura; et al, European Journal of Organic Chemistry, 2018, 2018(14), 1699-1708

Production Method 11

2142-69-0

91054-33-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Catalysts: Samarium Solvents: Dimethyl sulfoxide ;  12 h, 110 °C

Reference

A ligand and Palladium-free Avenue for Cyanation of Aryl Halides: The Art of Samarium Powder in C-C Coupling Reaction

Moghaddam, Firouz Matloubi ; Pourkaveh, Raheleh; Gholamtajari, Milad; Karimi, Ashkan, ChemistrySelect, 2019, 4(33), 9618-9621

Production Method 12

2142-68-9

91054-33-0

Reaction Conditions

1.1 Reagents: 4-(Dimethylamino)pyridine Catalysts: Zinc ,  Nickel dichloride ,  1,1-Bis(diphenylphosphino)ferrocene Solvents: Acetonitrile ;  6 h, 80 °C; 80 °C → rt

Reference

General and Mild Nickel-Catalyzed Cyanation of Aryl/Heteroaryl Chlorides with Zn(CN)2: Key Roles of DMAP

Zhang, Xingjie; Xia, Aiyou; Chen, Haoyi; Liu, Yuanhong, Organic Letters, 2017, 19(8), 2118-2121

Production Method 13

2142-70-3

91054-33-0

19222-23-2

Reaction Conditions

1.1 Catalysts: Tetrabutylammonium iodide Solvents: Dimethylformamide ,  tert-Butanol ,  Water ;  24 h, 110 °C

Reference

A Serendipitous One-Pot Cyanation/Hydrolysis/Enamide Formation: Direct Access to 3-Methyleneisoindolin-1-ones

Banik, Trisha; Kaliappan, Krishna P., Chemistry - A European Journal, 2021, 27(2), 628-633

Production Method 14

2142-69-0

91054-33-0

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  12 h, 150 °C

Reference

An Unprecedented, Lewis Acid-Mediated, Metal-Free Iodoannulation Strategy to Aromatic Iodides

Banik, Trisha; Betkekar, Vipul V.; Kaliappan, Krishna P., Chemistry - An Asian Journal, 2018, 13(23), 3676-3680

Production Method 15

91054-33-0

Reaction Conditions

1.1 Solvents: 1,2-Dimethoxyethane

Reference

Preparation of aryl, alkynyl, and vinyl organocopper compounds by the oxidative addition of zerovalent copper to carbon-halogen bonds

Ebert, Greg W.; Rieke, Reuben D., Journal of Organic Chemistry, 1988, 53(19), 4482-8

Production Method 16

131379-17-4

91054-33-0

Reaction Conditions

1.1 Catalysts: Cobalt dibromide Solvents: Acetonitrile ;  rt

Reference

A convenient method for the preparation of aromatic ketones from acyl chlorides and arylzinc bromides using a cobalt catalysis

Fillon, Hyacinthe; Gosmini, Corinne; Perichon, Jacques, Tetrahedron, 2003, 59(41), 8199-8202

Production Method 17

13943-58-3

2142-69-0

91054-33-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Bis[2-[2-(amino-κN)ethyl]-3-methoxyphenyl-κC]di-μ-bromodipalladium Solvents: Dimethylformamide ;  20 min, 130 °C

Reference

Microwave-enhanced cyanation of aryl halides with a dimeric ortho-palladated complex catalyst

Hajipour, Abdol-Reza; Abrisham, Fatemeh; Tavakoli, Ghazal, Transition Metal Chemistry (Dordrecht, 2011, 36(7), 725-730

Production Method 18

91054-33-0

Reaction Conditions

Reference

Product class 4: organometallic complexes of copper

Heaney, H.; Christie, S., Science of Synthesis, 2004, 3, 305-662

2-Acetylbenzonitrile Raw materials

• 1-(2-chlorophenyl)ethanone
• 2-cyanophenylzinc bromide
• (2-cyanophenyl)boronic acid
• Tert-BUTYL ISOCYANIDE
• Potassium hexacyanoferrate
• 2'-Aminoacetophenone
• 2'-Iodoacetophenone
• 2-Ethylbenzonitrile
• 2'-Bromoacetophenone
• 2-Iodobenzonitrile
• Trimethyl(vinyloxy)silane

2-Acetylbenzonitrile Preparation Products

• 2-Acetylbenzonitrile (91054-33-0)
• 1H-Isoindol-1-one, 2,3-dihydro-3-methylene- (19222-23-2)

• 1. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 2. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 5. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431

• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

• 684215-40-5(Benzonitrile, 3-acetyl-4-methyl- (9CI))
• 37774-78-0(Benzonitrile,2-benzoyl-)
• 912468-84-9(Benzonitrile, acetyl-)
• 93340-14-8(Benzonitrile,2-ethyl-3-formyl-)
• 40180-77-6(Benzonitrile, 5-acetyl-2-methyl- (9CI))
• 37649-98-2(2-Anthracenecarbonitrile, 9,10-dihydro-9,10-dioxo-)
• 64113-87-7(Benzonitrile,2-acetyl-5-methyl-)
• 6955-26-6( )
• 913485-57-1(4-(2-Methylphenyl)carbonylbenzonitrile)
• 496848-58-9(4-acetyl-3-methylbenzonitrile)