Production Method 1

90989-12-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  16 h, rt

Reference

Enantioselective synthesis of amino acids from ammonia

Li, Mao-Lin ; Pan, Jia-Bin; Zhou, Qi-Lin, Nature Catalysis, 2022, 5(6), 571-577

Production Method 2

90989-12-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ,  Dichloromethane ;  60 °C

Reference

Large scale enantiomeric synthesis, purification, and characterization of ω-unsaturated amino acids via a Gly-Ni(II)-BPB-complex

Gu, Xuyuan; Ndungu, John M.; Qiu, Wei; Ying, Jinfa; Carducci, Michael D.; et al, Tetrahedron, 2004, 60(37), 8233-8243

Production Method 3

90989-12-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ,  Water ;  rt; 50 °C

Reference

Asymmetric synthesis, biological activity and molecular docking studies of some unsaturated α-amino acids, derivatives of glycine, allylglycine and propargylglycine

Mkrtchyan, Anna F.; Saghyan, Ashot S.; Hayriyan, Liana A.; Sargsyan, Armen S.; Karapetyan, Ani J.; et al, Journal of Molecular Structure, 2020, 1208,

Production Method 4

375859-31-7

90989-12-1

Reaction Conditions

1.1 Reagents: Potassium hydroxide ,  Sulfuric acid magnesium salt (1:1) Solvents: Water
1.2 Reagents: Sulfuric acid Solvents: Water
1.3 Reagents: Benzaldehyde ,  Sodium hydroxide Solvents: Water

Reference

A biocatalytic route to enantiomerically pure unsaturated α-H-α-amino acids

Wolf, Larissa B.; Sonke, Theo; Tjen, Kim C. M. F.; Kaptein, Bernard; Broxterman, Quirinus B.; et al, Advanced Synthesis & Catalysis, 2001, 343, 662-674

Production Method 5

226985-05-3

90989-12-1

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  6 h, rt

Reference

Methylene analogs of neopetrosiamide as potential antimetastatic agents: solid-supported syntheses using diamino diacids for pre-stapling of peptides with multiple disulfides

Pascoe, Cameron A.; Engelhardt, Daniel B.; Rosana, Albert Remus R.; van Belkum, Marco J. ; Vederas, John C., Organic Letters, 2021, 23(23), 9216-9220

Production Method 6

90989-12-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ,  Water

Reference

A novel strategy toward [6,5]-bicyclic β-turn dipeptide

Gu, Xuyuan; Tang, Xuejun; Cowell, Scott; Ying, Jinfa; Hruby, Victor J., Tetrahedron Letters, 2002, 43(37), 6669-6672

Production Method 7

141943-64-8

90989-12-1

Reaction Conditions

1.1 Reagents: Potassium hydroxide ,  Monopotassium phosphate Solvents: Water ;  15 min, pH 7.5 - 8, 40 °C
1.2 Catalysts: Aminoacylase

Reference

Homoallylglycine residues are superior precursors to orthogonally modified thioether containing polypeptides

Perlin, Pesach; Gharakhanian, Eric G.; Deming, Timothy J., Chemical Communications (Cambridge, 2018, 54(48), 6196-6199

Production Method 8

226985-05-3

90989-12-1

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  1 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  1 h, 40 °C

Reference

Thiyl Glycosylation of Olefinic Proteins: S-Linked Glycoconjugate Synthesis

Floyd, Nicola; Vijayakrishnan, Balakumar; Koeppe, Julia R.; Davis, Benjamin G., Angewandte Chemie, 2009, 48(42), 7798-7802

Production Method 9

141943-64-8

90989-12-1

Reaction Conditions

1.1 Reagents: Potassium hydroxide ,  Monopotassium phosphate Catalysts: Aminoacylase Solvents: Water ;  pH 7.5 - 8, 40 °C
1.2 40 °C → 60 °C

Reference

Influence of Sulfoxide Group Placement on Polypeptide Conformational Stability

Gharakhanian, Eric G.; Bahrun, Ehab; Deming, Timothy J., Journal of the American Chemical Society, 2019, 141(37), 14530-14533

Production Method 10

141943-64-8

90989-12-1

142034-37-5

Reaction Conditions

1.1 Reagents: Lithium hydroxide Catalysts: Cobalt chloride (CoCl2) Solvents: Water ;  pH 7.5, 38 °C
1.2 Reagents: Ammonium hydroxide Catalysts: Aminoacylase ;  24 h, pH 7.5, 38 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3
1.4 Reagents: Dowex 50W-X8

Reference

α-Chymotrypsin and L-acylase aided synthesis of 5-hydroxypipecolic acid via Jacobsen's hydrolytic kinetic resolution of epoxy amino acids

Krishnamurthy, Suvratha; Venkataprasad, Jalli; Chand Vagvala, Tarun; Moriguchi, Tetsuji; Tsuge, Akihiko, RSC Advances, 2015, 5(64), 52154-52160

Production Method 11

141943-64-8

90989-12-1

103067-78-3

Reaction Conditions

1.1 Catalysts: Aminoacylase

Reference

Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects

Zajdel, Pawel ; Kos, Tomasz; Marciniec, Krzysztof; Satala, Grzegorz; Canale, Vittorio; et al, European Journal of Medicinal Chemistry, 2018, 145, 790-804

(2S)-2-aminohex-5-enoic acid Raw materials

• (2S)-Bis(1,1-dimethylethoxy)carbonylamino-5-hexenoic Acid 1,1-Dimethylethyl Ester
• 2-acetamidohex-5-enoic acid
• 2-Amino-5-hexenamide HCl

(2S)-2-aminohex-5-enoic acid Preparation Products

• 5-Hexenoic acid, 2-(acetylamino)-, (R)- (142034-37-5)
• (2R)-2-aminohex-5-enoic acid (103067-78-3)
• (2S)-2-aminohex-5-enoic acid (90989-12-1)

• 1. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 2. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 3. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 4. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 5. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
  Zhizhen Lai,Mo Zhang,Jinyu Zhou,Tianjing Chen,Dan Li,Xuejing Shen,Jia Liu,Jiang Zhou,Zhili Li Analyst, 2021,146, 4261-4267

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 1140737-02-5((S)-2-Aminooct-7-enoic acid)
• 73322-75-5(5-methylidene-L-norleucine)
• 10325-17-4(2-Aminohept-6-enoic acid)
• 924307-76-6((2S)-2-aminonon-8-enoic acid)
• 103067-79-4((R)-2-(4’-pentenyl) glycine)
• 16258-05-2(2-aminohex-5-enoic acid)
• 56472-43-6(9-Octadecenoic acid,2-amino-, (9Z)-)
• 103067-78-3((2R)-2-aminohex-5-enoic acid)
• 89895-48-7(2-Amino-6-heptenoic Acid Hydrochloride)
• 166734-64-1((2S)-2-aminohept-6-enoic acid)