Production Method 1

19005-93-7

90888-62-3

Reaction Conditions

1.1 Solvents: Methanol ;  4 h, rt
1.2 Reagents: Sodium borohydride ;  10 min, 0 °C; 0 °C → rt

Reference

Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity

Li, Baoli; Ni, Shuaishuai; Mao, Fei; Chen, Feifei ; Liu, Yifu; et al, Journal of Medicinal Chemistry, 2018, 61(1), 224-250

Production Method 2

1477-50-5

90888-62-3

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ;  12 h, rt
1.2 Solvents: Dichloromethane ;  0 °C; overnight, rt
1.3 Reagents: Lithium aluminum hydride Solvents: 1,4-Dioxane ;  0 °C; overnight, reflux
1.4 Reagents: Sodium sulfate Solvents: Water ;  0 °C
1.5 Reagents: Sodium hydroxide Solvents: Water ;  pH 10

Reference

Synthesis of heteroarylogous 1H-indole-3-carboxamidines via a three-component interrupted Ugi reaction

La Spisa, Fabio; Meneghetti, Fiorella; Pozzi, Beatrice; Tron, Gian Cesare, Synthesis, 2015, 47(4), 489-496

(1H-Indol-2-ylmethyl)methylamine Raw materials

• Indole-2-carbaldehyde
• Indole-2-carboxylic acid

(1H-Indol-2-ylmethyl)methylamine Preparation Products

• (1H-Indol-2-ylmethyl)methylamine (90888-62-3)

• 1. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
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• 5. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indoles

Comprehensive Guide to (1H-Indol-2-ylmethyl)methylamine (CAS No. 90888-62-3): Properties, Applications, and Market Insights

(1H-Indol-2-ylmethyl)methylamine (CAS No. 90888-62-3) is a specialized organic compound with a molecular structure that combines an indole ring system with a methylamine substituent. This unique configuration makes it a valuable intermediate in pharmaceutical and biochemical research. The compound is also referred to as 2-(methylaminomethyl)indole, highlighting its structural features. Researchers and industry professionals often search for terms like "(1H-Indol-2-ylmethyl)methylamine synthesis", "CAS 90888-62-3 applications", and "indole derivatives in drug discovery", reflecting its growing importance in scientific communities.

The physical and chemical properties of (1H-Indol-2-ylmethyl)methylamine contribute to its versatility. With a molecular formula of C₁₀H₁₂N₂, it typically appears as a light-colored crystalline solid under standard conditions. Its indole-methylamine hybrid structure provides both aromatic character and basic nitrogen functionality, enabling diverse reactivity patterns. Recent studies have focused on its solubility profile and stability parameters, which are crucial for formulation scientists working on novel drug delivery systems.

In pharmaceutical applications, (1H-Indol-2-ylmethyl)methylamine serves as a key building block for neurologically active compounds. The indole nucleus is structurally similar to serotonin and melatonin, making derivatives of this compound particularly interesting for CNS drug development. Current research trends explore its potential in designing selective receptor modulators, with particular attention to neurodegenerative disease treatments—a hot topic in medical chemistry circles. Scientists frequently investigate "indoleamine analogs in Parkinson's research" and "methylaminoindole derivatives as cognitive enhancers", demonstrating the compound's relevance.

The synthetic chemistry of 90888-62-3 has seen significant advancements in recent years. Modern green chemistry approaches have developed more efficient routes to this intermediate, reducing environmental impact—a major concern in today's chemical industry. Techniques such as catalytic amination and microwave-assisted synthesis have improved yields while minimizing waste generation. These developments align with growing searches for "sustainable indole derivative production" and "eco-friendly heterocyclic synthesis methods".

Analytical characterization of (1H-Indol-2-ylmethyl)methylamine employs advanced techniques including HPLC-MS, NMR spectroscopy, and X-ray crystallography. Quality control protocols for this compound emphasize purity assessment and isomeric composition, critical factors for research reproducibility. The analytical data available for CAS 90888-62-3 supports its use in high-throughput screening programs and structure-activity relationship studies.

Market dynamics for indole-based intermediates like (1H-Indol-2-ylmethyl)methylamine show steady growth, driven by expanding pharmaceutical R&D budgets worldwide. Suppliers have responded to increasing demand by offering custom synthesis services and scale-up capabilities for this compound. Industry reports tracking "specialty chemicals market trends" and "pharmaceutical intermediate pricing" often feature this chemical class due to its commercial significance.

From a regulatory perspective, 90888-62-3 is properly classified and documented in major chemical inventories. Proper handling procedures and storage conditions are well-established, ensuring safe laboratory use. The compound's safety data has been thoroughly evaluated, with comprehensive information available about its toxicological profile and environmental fate—topics frequently searched by EHS professionals.

Future research directions for (1H-Indol-2-ylmethyl)methylamine may explore its potential in material science applications, particularly in developing functional polymers or organic electronic components. The compound's electron-rich aromatic system and coordinating nitrogen atoms make it an interesting candidate for molecular engineering projects. Such interdisciplinary applications are gaining attention, as seen in search trends for "indole compounds in advanced materials".

For researchers sourcing CAS 90888-62-3, current best practices include verifying supplier credentials and requesting full analytical certificates. The compound is available in various packaging options ranging from milligram quantities for discovery research to kilogram scales for process development. Procurement specialists often search for "reliable (1H-Indol-2-ylmethyl)methylamine suppliers" and "bulk indole derivative pricing" when sourcing this material.

In conclusion, (1H-Indol-2-ylmethyl)methylamine represents an important chemical tool with wide-ranging scientific utility. Its unique structure bridges medicinal chemistry and materials science, while ongoing methodological improvements enhance its accessibility. As research into indole-containing compounds continues to expand, 90888-62-3 will likely maintain its position as a valuable intermediate for innovation across multiple disciplines.

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