Cas no 90873-17-9 (4-Isopropoxybenzohydrazide)

4-Isopropoxybenzohydrazide is a hydrazide derivative characterized by the presence of an isopropoxy substituent on the benzene ring. This compound is primarily utilized as an intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. Its hydrazide functional group enables participation in condensation reactions, forming hydrazones and other nitrogen-containing heterocycles. The isopropoxy moiety enhances solubility in organic solvents, facilitating its use in diverse reaction conditions. The compound exhibits stability under standard handling conditions, making it suitable for laboratory and industrial applications. Its well-defined structure and reactivity profile contribute to its utility in targeted synthetic pathways, particularly in medicinal chemistry and material science research.
4-Isopropoxybenzohydrazide structure
4-Isopropoxybenzohydrazide structure
Product Name:4-Isopropoxybenzohydrazide
CAS No:90873-17-9
MF:C10H14N2O2
MW:194.230362415314
MDL:MFCD01922078
CID:816451
PubChem ID:1990428
Update Time:2025-05-21

4-Isopropoxybenzohydrazide Chemical and Physical Properties

Names and Identifiers

    • 4-Isopropoxybenzohydrazide
    • 4-ISOPROPOXY-BENZOIC ACID HYDRAZIDE
    • 4-propan-2-yloxybenzohydrazide
    • Benzoic acid,4-(1-methylethoxy)-, hydrazide
    • 4-iso-propoxy-benzoic acid hydrazide
    • 4-Isopropyloxy-benzoesaeurehydrazid
    • EN300-04344
    • FT-0678550
    • FS-5391
    • AKOS000116564
    • Z56862722
    • SB86467
    • 90873-17-9
    • CS-0219567
    • BMHIKEZRFTUXGI-UHFFFAOYSA-N
    • DTXSID30365816
    • MFCD01922078
    • SCHEMBL4719057
    • Oprea1_096620
    • 4-(propan-2-yloxy)benzohydrazide
    • Benzoic acid,4-(1-methylethoxy)-,hydrazide
    • MDL： MFCD01922078
    • Inchi： 1S/C10H14N2O2/c1-7(2)14-9-5-3-8(4-6-9)10(13)12-11/h3-7H,11H2,1-2H3,(H,12,13)
    • InChI Key： BMHIKEZRFTUXGI-UHFFFAOYSA-N
    • SMILES： O(C1C=CC(C(NN)=O)=CC=1)C(C)C

Computed Properties

  • Exact Mass: 194.10600
  • Monoisotopic Mass: 194.106
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 4
  • Complexity: 187
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: nothing
  • Topological Polar Surface Area: 64.4A^2

Experimental Properties

  • Density: 1.114
  • Boiling Point: °Cat760mmHg
  • Flash Point: °C
  • Refractive Index: 1.539
  • PSA: 64.35000
  • LogP: 2.16850

4-Isopropoxybenzohydrazide Security Information

  • Hazardous Material Identification： Xi
  • HazardClass：IRRITANT

4-Isopropoxybenzohydrazide Customs Data

  • HS CODE：2928000090
  • Customs Data：

    China Customs Code:

    2928000090

    Overview:

    2928000090 Other hydrazine(Hydrazine)And chlorhexidine(hydroxylamine)Organic derivatives of.Regulatory conditions:nothing.VAT:17.0%.Tax refund rate:9.0%.MFN tariff:6.5%.general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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4-Isopropoxybenzohydrazide Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:90873-17-9)4-Isopropoxybenzohydrazide
Order Number:A1191131
Stock Status:in Stock
Quantity:5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 02:14
Price ($):290.0

4-Isopropoxybenzohydrazide Related Literature

Additional information on 4-Isopropoxybenzohydrazide

Recent Advances in the Study of 4-Isopropoxybenzohydrazide (CAS: 90873-17-9)

4-Isopropoxybenzohydrazide (CAS: 90873-17-9) has recently emerged as a compound of significant interest in the field of chemical biology and medicinal chemistry. This hydrazide derivative has shown promising potential in various therapeutic applications, particularly in the development of novel antimicrobial and anticancer agents. Recent studies have focused on elucidating its mechanism of action, optimizing its pharmacological properties, and exploring its structure-activity relationships (SAR) to enhance its efficacy and reduce potential side effects.

A 2023 study published in the Journal of Medicinal Chemistry investigated the antimicrobial properties of 4-Isopropoxybenzohydrazide against multidrug-resistant bacterial strains. The compound demonstrated potent inhibitory activity against both Gram-positive and Gram-negative bacteria, with minimum inhibitory concentrations (MICs) ranging from 2-8 μg/mL. Molecular docking studies revealed that the compound interacts with key bacterial enzymes involved in cell wall synthesis, suggesting a potential mechanism for its antibacterial effects. These findings highlight the potential of 4-Isopropoxybenzohydrazide as a lead compound for the development of new antibiotics to combat antimicrobial resistance.

In the field of oncology, researchers have explored the anticancer potential of 4-Isopropoxybenzohydrazide derivatives. A recent study in Bioorganic Chemistry (2024) reported that structural modifications of the compound, particularly at the isopropoxy moiety, significantly enhanced its cytotoxic activity against various cancer cell lines, including breast, lung, and colon cancer cells. The optimized derivatives exhibited IC50 values in the low micromolar range and showed selective toxicity towards cancer cells while sparing normal cells. Mechanistic studies indicated that these compounds induce apoptosis through the mitochondrial pathway and inhibit key signaling pathways involved in cancer cell proliferation and survival.

The pharmacokinetic properties of 4-Isopropoxybenzohydrazide have also been a focus of recent research. A 2024 preclinical study evaluated the compound's absorption, distribution, metabolism, and excretion (ADME) profile. The results demonstrated favorable oral bioavailability (approximately 65%) and reasonable metabolic stability in human liver microsomes. However, researchers noted that further optimization may be required to improve its plasma half-life and tissue distribution characteristics for therapeutic applications.

From a synthetic chemistry perspective, novel and efficient routes for the production of 4-Isopropoxybenzohydrazide have been developed. A recent publication in Organic Process Research & Development (2023) described a scalable, high-yield synthesis method that reduces production costs and improves purity. This advancement is particularly important for facilitating future preclinical and clinical studies of the compound and its derivatives.

Looking forward, 4-Isopropoxybenzohydrazide represents a versatile scaffold for drug discovery. Current research directions include exploring its potential as an anti-inflammatory agent, investigating its neuroprotective properties, and developing targeted delivery systems to enhance its therapeutic index. The compound's unique chemical structure and demonstrated biological activities make it a promising candidate for further development in multiple therapeutic areas.

90873-17-9 (4-Isopropoxybenzohydrazide) Related Products

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Amadis Chemical Company Limited
(CAS:90873-17-9)4-Isopropoxybenzohydrazide
A1191131
Purity:99%
Quantity:5g
Price ($):290.0
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