Production Method 1

55417-34-0

90843-62-2

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  3 h, reflux
1.2 Reagents: Aluminum chloride Solvents: Dichloromethane ;  reflux; 3 h, 0 - 5 °C
1.3 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  overnight, reflux

Reference

Truxene discotic liquid crystals with two different ring substituents: synthesis, mesomorphism and high charged carrier mobility

Ni, Hai-Liang; Monobe, Hirosato; Hu, Ping; Wang, Bi-Qin; Shimizu, Yo; et al, Liquid Crystals, 2013, 40(3), 411-420

Production Method 2

1135-23-5

90843-62-2

Reaction Conditions

1.1 Reagents: Hydrofluoric acid

Reference

Physiologically active indanamines. II. Compounds substituted in the aromatic ring

Heinzelmann, R. V.; Kolloff, H. G.; Hunter, James H., Journal of the American Chemical Society, 1948, 70, 1386-90

Production Method 3

1135-24-6

90843-62-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  40 °C
1.2 Reagents: Methanesulfonic anhydride ;  120 °C

Reference

Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents

Hu, Jinhui; Yan, Jun; Chen, Jie; Pang, Yanqing; Huang, Ling; et al, MedChemComm, 2015, 6(7), 1318-1327

Production Method 4

1135-23-5

90843-62-2

Reaction Conditions

1.1 Catalysts: Methanesulfonic acid ;  1 h, 120 °C

Reference

Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents

Meng, Fan-Chao; Mao, Fei; Shan, Wen-Jun; Qin, Fangfei; Huang, Ling; et al, Bioorganic & Medicinal Chemistry Letters, 2012, 22(13), 4462-4466

Production Method 5

1135-23-5

90843-62-2

Reaction Conditions

1.1 Reagents: Methanesulfonic acid ;  1 h, 120 °C; 120 °C → rt; 5 min, cooled

Reference

Combining chalcones with donepezil to inhibit both cholinesterases and Aβ fibril assembly

Chandrika, Nishad Thamban; Fosso, Marina Y.; Tsodikov, Oleg V.; Levine, Harry III; Garneau-Tsodikova, Sylvie, Molecules, 2020, 25(1),

Production Method 6

1135-23-5

90843-62-2

Reaction Conditions

1.1 Reagents: Methanesulfonic acid ;  1 h, 120 °C; 120 °C → rt
1.2 Reagents: Water ;  5 min, cooled

Reference

Multifunctional donepezil analogues as cholinesterase and BACE1 inhibitors

Green, Keith D.; Fosso, Marina Y.; Garneau-Tsodikova, Sylvie, Molecules, 2018, 23(12), 3252/1-3252/22

Production Method 7

1135-23-5

90843-62-2

Reaction Conditions

1.1 Reagents: Methanesulfonic acid ;  1 h, 120 °C

Reference

Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease

Huang, Ling; Miao, Hui; Sun, Yang; Meng, Fanchao; Li, Xingshu, European Journal of Medicinal Chemistry, 2014, 87, 429-439

Production Method 8

90843-62-2

Reaction Conditions

1.1 Reagents: Carbon disulfide ,  Aluminum chloride ;  rt

Reference

Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate

Zhou, Yu ; Fu, Yan; Yin, Wanchao; Li, Jian; Wang, Wei; et al, Journal of Medicinal Chemistry, 2021, 64(4), 1844-1855

Production Method 9

55417-34-0

90843-62-2

Reaction Conditions

1.1 Reagents: Aluminum chloride ,  Thionyl chloride Solvents: Dichloromethane
1.2 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water

Reference

The influence of alkyl chain substitution pattern on the two- and three-dimensional self-assembly of truxenone discogens

Ruan, Peng; Xiao, Bo; Ni, Hai-Liang; Hu, Ping; Wang, Bi-Qin; et al, Liquid Crystals, 2014, 41(8), 1152-1161

Production Method 10

90843-62-2

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Dimethylformamide ;  0 °C; 24 h, rt
1.2 Reagents: Aluminum chloride Solvents: Dichloromethane ;  0 °C; 3 h, < 15 °C

Reference

Synthesis and mesomorphism of ether-ester mixed tail C3-symmetrical truxene discotic liquid crystals

Li, Li-Li; Hu, Ping; Wang, Bi-Qin; Yu, Wen-Hao; Shimizu, Yo; et al, Liquid Crystals, 2010, 37(5), 499-506

Production Method 11

90843-62-2

Reaction Conditions

1.1 Catalysts: L-Proline Solvents: Acetic acid ;  24 h, 120 °C

Reference

A metal-free method for the facile synthesis of indanones via the intramolecular hydroacylation of 2-vinylbenzaldehyde

He, Guoxue; Ma, Jinyu; Zhou, Jianhui; Li, Chunpu; Liu, Hong; et al, Green Chemistry, 2021, 23(2), 1036-1040

Production Method 12

124702-80-3

90843-62-2

Reaction Conditions

1.1 Reagents: Lithium carbonate (Li2CO3) Solvents: Dimethylformamide ;  55 °C

Reference

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral bioavailability

Tong, Yunsong; Przytulinska, Magdalena; Tao, Zhi-Fu; Bouska, Jennifer; Stewart, Kent D.; et al, Bioorganic & Medicinal Chemistry Letters, 2007, 17(20), 5665-5670

Production Method 13

124702-80-3

90843-62-2

Reaction Conditions

1.1 Reagents: Lithium carbonate (Li2CO3) Solvents: Dimethylformamide

Reference

Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors

Tao, Zhi-Fu; Li, Gaoquan; Tong, Yunsong; Chen, Zehan; Merta, Philip; et al, Bioorganic & Medicinal Chemistry Letters, 2007, 17(15), 4308-4315

Production Method 14

1135-23-5

90843-62-2

Reaction Conditions

1.1 Reagents: Methanesulfonic acid ;  rt → 90 °C

Reference

Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors

Brullo, Chiara; Rapetti, Federica ; Abbate, Sara ; Prosdocimi, Tommaso; Torretta, Archimede ; et al, European Journal of Medicinal Chemistry, 2021, 223,

Production Method 15

55417-34-0

90843-62-2

Reaction Conditions

1.1 Reagents: Thionyl chloride
1.2 Reagents: Aluminum chloride Solvents: Dichloromethane
1.3 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water

Reference

Effect of methoxy groups on liquid crystalline and self-assembling properties of 2,7,12-tris(methoxy)-3,8,13-tris(alkoxy)-5,10,15-truxenones

Xu, Hong-Tian; Xia, Xue; Yu, Wen-Hao; Feng, Chun ; Xiang, Shi-Kai; et al, Liquid Crystals, 2021, 48(1), 111-120

Production Method 16

124702-80-3

90843-62-2

Reaction Conditions

1.1 Reagents: Lithium carbonate (Li2CO3) Solvents: Dimethylformamide ;  3 h, 55 °C

Reference

Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer's Disease

Huang, Ling; Lu, Chuanjun; Sun, Yang; Mao, Fei; Luo, Zonghua; et al, Journal of Medicinal Chemistry, 2012, 55(19), 8483-8492

6-Hydroxy-5-methoxy-1-indanone Raw materials

• BENZENEPROPANOIC ACID, 4-(ACETYLOXY)-3-METHOXY-
• Ferulic acid
• Dihydroferulic acid
• 5,6-Dihydroxy-2,3-dihydro-1H-inden-1-one

6-Hydroxy-5-methoxy-1-indanone Preparation Products

• 6-Hydroxy-5-methoxy-1-indanone (90843-62-2)

• 1. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 2. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 3. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 4. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693

• Solvents and Organic Chemicals Organic Compounds Benzenoids Indanes Indanones

• 6342-80-9(4,5-Dimethoxy-1-indanone)
• 13575-75-2(6,7-Dimethoxy-1-tetralone)
• 13623-25-1(6-methoxyindan-1-one)
• 5111-70-6(5-Methoxy-1-indanone)
• 6500-65-8(2-Methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one)
• 2107-69-9(5,6-Dimethoxy-1-indanone)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)