Production Method 1

99-76-3

90812-66-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Water ;  5 min, 100 °C

Reference

Microwave (MW), ultrasound (US) and Combined Synergic MW-US strategies for rapid functionalization of pharmaceutical use phenols

Pawelczyk, Anna; Sowa-Kasprzak, Katarzyna; Olender, Dorota; Zaprutko, Lucjusz, Molecules, 2018, 23(9), 2360/1-2360/15

Production Method 2

35005-30-2

90812-66-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ,  Water

Reference

UV-spectral behavior of some newly synthesized half-esters

Adak, Mohini Mohan, Asian Journal of Chemistry, 1992, 4(4), 920-3

Production Method 3

35005-30-2

90812-66-1

Reaction Conditions

1.1 Catalysts: Esterase

Reference

Aromatic vs aliphatic methyl esters: preferential hydrolysis of latter by pig liver esterase

Basak, Amit; Bhattacharya, Gautam; Mallik, Uttam Kumar, Biotechnology Letters, 1994, 16(12), 1303-4

Production Method 4

79704-02-2

90812-66-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Water
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Use of phosphorus pentoxide. Preparation of half-esters through selective esterification

Banerjee, Amalendu; Adak, Mohini Mohan; Das, Sankar; Banerjee, Santa; Sengupta, Saumitra, Journal of the Indian Chemical Society, 1987, 64(1), 34-7

Production Method 5

99-76-3

90812-66-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  5 min, 85 - 90 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3

Reference

Linked drug-drug conjugates based on triterpene and phenol structures. Rational synthesis, molecular properties, toxicity and bioactivity prediction

Pawelczyk, Anna; Olender, Dorota ; Sowa-Kasprzak, Katarzyna ; Zaprutko, Lucjusz, Arabian Journal of Chemistry, 2020, 13(12), 8793-8806

4-(Carboxymethoxy)benzoic Acid 1-Methyl Ester Raw materials

• Methyl (4-methoxyphenoxy)acetate
• Methyl 4-(2-methoxy-2-oxoethoxy)benzoate
• Methyl Paraben

4-(Carboxymethoxy)benzoic Acid 1-Methyl Ester Preparation Products

• 4-(Carboxymethoxy)benzoic Acid 1-Methyl Ester (90812-66-1)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenoxyacetic acid derivatives

• 23676-08-6(Methyl 4-Ethyloxybenzoate)
• 32122-11-5(Methyl 4-benzyloxybenzoate)
• 73620-18-5(Methyl 2-(4-formylphenoxy)acetate)
• 19360-67-9(4-H2CPA)
• 62290-48-6(Methyl 4-(4-Methylbenzyl)oxybenzenecarboxylate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)