- Microbial oxidation of ebastineSchwartz, H.; Liebig-Weber, A.; Hochstaetter, H.; Boettcher, H., Applied Microbiology and Biotechnology, 1996, 44(6), 731-5
Cas no 90729-42-3 (Carebastine)
Carebastine is a selective, non-sedating antihistamine with potent H1-receptor antagonist properties. It is primarily used in the treatment of allergic conditions, including rhinitis and conjunctivitis, due to its ability to effectively inhibit histamine-mediated inflammatory responses. Carebastine demonstrates high bioavailability and a prolonged duration of action, ensuring sustained therapeutic effects. Its low affinity for central nervous system receptors minimizes drowsiness, a common side effect of first-generation antihistamines. The compound exhibits favorable pharmacokinetics, with rapid absorption and extensive tissue distribution. Carebastine's metabolite, ebastine, further contributes to its efficacy. Its well-characterized safety profile makes it suitable for long-term use in managing chronic allergic disorders.
Carebastine structure
Product Name:Carebastine
CAS No:90729-42-3
MF:C32H37NO4
MW:499.640489339828
MDL:MFCD00865665
CID:827100
PubChem ID:65820
Update Time:2025-05-22
Carebastine Chemical and Physical Properties
Names and Identifiers
-
- 2-(4-(4-(4-(Benzhydryloxy)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoic acid
- Carebastine
- 2-(4-(4-(4-(Benzhydryloxy)piperidin-1-yl)-butanoyl)phenyl)-2-methylpropanoic acid
- C32H37NO4
- Carebastina
- Carebastinum
- UNII-75DLN707DO
- 4-[4-[4-(Diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid (ACI)
- AKOS016010168
- Carebastinum [Latin]
- DTXCID80160737
- BRD-K49554218-001-01-0
- CHEBI:192413
- SCHEMBL18538
- CS-0081566
- Benzeneacetic acid, 4-(4-(4-(diphenylmethoxy)-1-piperidinyl)-1-oxobutyl)-alpha,alpha-dimethyl-
- NS00126598
- 75DLN707DO
- XGHOVGYJHWQGCC-UHFFFAOYSA-N
- 4-[4-[4-(Diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-alpha,alpha-dimethylbenzeneacetic Acid
- MFCD00865665
- Carebastina [Spanish]
- A1-50277
- p-(4-(4-(Diphenylmethoxy)piperidino)butyryl)-alpha-methylhydratropic acid
- 2-[4-[4-(4-benzhydryloxypiperidin-1-yl)butanoyl]phenyl]-2-methylpropanoic acid
- Carebastinum (Latin)
- SR-01000945064
- 2-(4-(4-(4-Benzhydryloxypiperidino)butyryl)phenyl)-2-methylpropionsaeure
- 90729-42-3
- W15627
- Carebastine [INN]
- CHEMBL67654
- HY-121356
- DTXSID60238246
- 2-(4-{4-[4-(Benzhydryloxy)-1-piperidinyl]butanoyl}phenyl)-2-methylpropanoic acid
- BS-29762
- SR-01000945064-1
- Q27266380
- 4-[4-[4-(Diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-a,a-dimethylbenzeneacetic Acid;
-
- MDL： MFCD00865665
- Inchi： 1S/C32H37NO4/c1-32(2,31(35)36)27-17-15-24(16-18-27)29(34)14-9-21-33-22-19-28(20-23-33)37-30(25-10-5-3-6-11-25)26-12-7-4-8-13-26/h3-8,10-13,15-18,28,30H,9,14,19-23H2,1-2H3,(H,35,36)
- InChI Key： XGHOVGYJHWQGCC-UHFFFAOYSA-N
- SMILES： O=C(C(C)(C)C1C=CC(C(CCCN2CCC(OC(C3C=CC=CC=3)C3C=CC=CC=3)CC2)=O)=CC=1)O
Computed Properties
- Exact Mass: 499.27200
- Monoisotopic Mass: 499.272259
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 37
- Rotatable Bond Count: 11
- Complexity: 690
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: 2
- XLogP3: 3.6
- Topological Polar Surface Area: 66.8
Experimental Properties
- Color/Form: Gray white solid
- Density: 1.18
- Melting Point: 178-180°C
- Boiling Point: 657.9°C at 760 mmHg
- Flash Point: 351.7°C
- Refractive Index: 1.608
- PSA: 66.84000
- LogP: 6.22020
Carebastine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM180611-1g |
2-(4-(4-(4-(Benzhydryloxy)piperidin-1-yl)-butanoyl)phenyl)-2-methylpropanoic acid |
90729-42-3 | 95% | 1g |
$1352 | 2021-08-05 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci20638-5mg |
Carebastine |
90729-42-3 | 98% | 5mg |
￥629.00 | 2023-09-09 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci20638-10mg |
Carebastine |
90729-42-3 | 98% | 10mg |
￥940.00 | 2023-09-09 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci20638-25mg |
Carebastine |
90729-42-3 | 98% | 25mg |
￥1340.00 | 2023-09-09 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T10680-1 mg |
Carebastine |
90729-42-3 | 99.06% | 1mg |
￥997.00 | 2022-04-26 | |
| TRC | C183440-5mg |
Carebastine |
90729-42-3 | 5mg |
$ 80.00 | 2023-09-08 | ||
| TRC | C183440-10mg |
Carebastine |
90729-42-3 | 10mg |
$ 121.00 | 2023-04-18 | ||
| TRC | C183440-25mg |
Carebastine |
90729-42-3 | 25mg |
$ 148.00 | 2023-09-08 | ||
| TRC | C183440-50mg |
Carebastine |
90729-42-3 | 50mg |
$ 190.00 | 2023-09-08 | ||
| TRC | C183440-100mg |
Carebastine |
90729-42-3 | 100mg |
$ 413.00 | 2023-04-18 |
Carebastine Production Method
Production Method 1
Reaction Conditions
Reference
Production Method 2
Reaction Conditions
1.1 Solvents: Dimethylformamide , Water ; 7 d, pH 6.5, 30 °C
Reference
- Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastineMazier, Claire; Jaouen, Maryse; Sari, Marie-Agnes; Buisson, Didier, Bioorganic & Medicinal Chemistry Letters, 2004, 14(21), 5423-5426
Production Method 3
Reaction Conditions
1.1 Solvents: Dimethylformamide , Water ; pH 5, 30 °C
Reference
- Biooxidation of methyl group: application to the preparation of alcohol and acid metabolites of terfenadine, ebastine and analoguesEl Ouarradi, Amane; Salard-Arnaud, Isabelle; Buisson, Didier, Tetrahedron, 2008, 64(51), 11738-11744
Carebastine Raw materials
Carebastine Preparation Products
Carebastine Related Literature
-
Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
-
Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
-
Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
-
Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
-
Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
90729-42-3 (Carebastine) Related Products
- 210686-41-2(Hydroxy Ebastine)
- 189064-48-0(Carebastine Methyl Ester)
- 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
- 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
- 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
- 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
- 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
- 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
- 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
- 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
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