- All-Red-Light Photoswitching of Indirubin Controlled by Supramolecular InteractionsThumser, Stefan; Koettner, Laura; Hoffmann, Nadine; Mayer, Peter; Dube, Henry, Journal of the American Chemical Society, 2021, 143(43), 18251-18260
Cas no 906748-38-7 ((Z)-2,3’-Biindolinylidene-2’,3-dione)
906748-38-7 structure
Product Name:(Z)-2,3’-Biindolinylidene-2’,3-dione
CAS No:906748-38-7
MF:C16H10N2O2
MW:262.262803554535
MDL:MFCD00956441
CID:1954065
PubChem ID:329825288
Update Time:2024-10-26
(Z)-2,3’-Biindolinylidene-2’,3-dione Chemical and Physical Properties
Names and Identifiers
-
- (3e)-3-(3-oxo-1,3-dihydro-2h-indol-2-ylidene)-1,3-dihydro-2h-indo L-2-one
- 3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one; [Δ2,3′-Biindoline]-2′,3-dione (7CI,8CI)
- C.I. 73200
- Couroupitine B
- Indigo red
- Indigopurpurin
- NSC 105327
- Indirubin
- [2,3'-Biindolinylidene]-2',3-dione
- (Z)-[2,3'-biindolinylidene]-2',3-dione
- 3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one
- (E)-[2,3'-biindolinylidene]-2',3-dione
- 1LXW6D3W2Z
- 2H-Indol-2-one, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-
- (Z)-[2,3 inverted exclamation mark -Biindolinylidene]-2 inverted exclamation mark ,3-dione
- V86L8P74GI
- (3Z)-3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one (ACI)
- (2Z)-2-(2-Oxoindolin-3-ylidene)indolin-3-one
- (2′Z)-Indirubin
- (3Z)-3-(3-Oxoindolin-2-ylidene)indolin-2-one
- CCG-100673
- KBio2_005586
- PD003207
- AKOS015895136
- KBio3_000839
- 1ST157073
- NC00308
- AC-29931
- HMS1362H11
- 906748-38-7
- 3-(1,3-dihydro-3-oxo-2h-indol-2-ylidene)-1,3-dihydro-2h-indol-2-on
- MLS006010732
- s2386
- KBioGR_000450
- MLS002473308
- 2-(2-oxo-1H-indol-3-ylidene)-1H-indol-3-one
- [.DELTA.2,3-dione
- BiomolKI_000069
- BDBM50349806
- Indirubin (NSC 105327; Couroupitine B)
- NCGC00163356-04
- Q-100514
- 2H-Indol-2-one,3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-
- NS00011738
- MLS001424211
- SW197688-2
- SMR004701694
- AC1180
- cid_5318433
- CS-12423
- SR-01000759396
- 3-(3-indolinone-2-ylidene)-indolin-2-one
- Isoindirubine
- BRN 0088279
- AB00639939-06
- 397242-72-7
- LS-14462
- UNII-1LXW6D3W2Z
- NCGC00163356-01
- BDBM7392
- NSC-827101
- (3z)-3-(3-oxo-1,3-dihydro-2h-indol-2-ylidene)-1,3-dihydro-2h-indol-2-one
- HMS2234G06
- 3-(3-oxoindolin-2-ylidene)indolin-2-one
- UNM-0000305766
- CHEMBL35349
- Q27164070
- (3E)-3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one
- (2'Z)-Indirubin, >=98% (HPLC)
- INDIRUBIN [WHO-DD]
- FD9058
- KBioSS_000450
- CHEBI:92322
- (E)-3-(3-oxoindolin-2-ylidene)indolin-2-one
- Indirubin,(S)
- Isoindirubin
- 479-41-4
- AKOS032455876
- I0868
- MLS000759416
- IndirubinCouroupitine B; Indigopurpurin
- SR-01000759396-5
- DTXSID201026053
- Indirubin [MI]
- CHEMBL259664
- Indirubin 3E-form [MI]
- NCGC00163356-02
- 2H-Indol-2-one,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-
- BI164578
- BSPBio_001110
- HMS3656O13
- C.I. 75790
- CPD000466311
- BCP28869
- MFCD00221745
- (delta2,3'-Biindoline)-2',3-dione
- SY058396
- (Z)-[2,3invertedexclamationmark-Biindolinylidene]-2invertedexclamationmark,3-dione
- NSC105327
- 2-(2-hydroxy-1H-indol-3-yl)indol-3-one
- NSC827101
- Bio2_000875
- (delta(sup 2,3')-BIINDOLINE)-2',3-DIONE
- HMS3369O15
- SCHEMBL27678
- 5-24-08-00507 (Beilstein Handbook Reference)
- HMS1990H11
- NS00101121
- BRD-K17894950-001-03-6
- DA-54305
- CS-3682
- KBio3_000840
- EM-A05-INDIRUBIN
- HMS3403H11
- CHEMBL1276127
- Q1661452
- Indirubin derivative, 1
- Isoindogotin
- EX-A347
- 3-(1,3-dihydro-3-oxo-2h-indol-2-ylidene)-1,3-dihydro-2h-indol-2-one
- Indirubin?
- SCHEMBL9899338
- 2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-dihydro-1H-indol-3-one
- HY-N0117
- BDBM50023867
- CHEMBL3185783
- BCP9000788
- DB-179341
- UNII-V86L8P74GI
- SMR000466311
- KBio2_003018
- Indirubin- Bio-X
- BRD-K17894950-001-04-4
- DTXSID501026052
- IDI1_002150
- SDCCGSBI-0634263.P002
- NCGC00179302-02
- NCGC00163356-03
- HMS1792H11
- BMK1-G9
- BiomolKI2_000073
- INDARUBICIN
- Bio2_000395
- HMS2051H20
- KBio2_000450
- MFCD00956441
- CCG-267073
- HMS3393H20
- AKOS028108775
- 2H-Indol-2-one, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-, (3E)-
- (Z)-[2,3-Biindolinylidene]-2,3-dione
- CCG-101058
- AC-8003
- DB12379
- SB64698
- BRD-K17894950-001-14-3
- NSC-105327
- CRDNMYFJWFXOCH-UHFFFAOYSA-N
- (3Z)-3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one
- (Z)-2,3’-Biindolinylidene-2’,3-dione
-
- MDL： MFCD00956441
- Inchi： 1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13-
- InChI Key： CRDNMYFJWFXOCH-YPKPFQOOSA-N
- SMILES： O=C1NC2C=CC=CC=2/C/1=C1\C(=O)C2C=CC=CC=2N\1
- BRN： 0088279
Computed Properties
- Exact Mass: 262.074227566g/mol
- Monoisotopic Mass: 262.074227566g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 20
- Rotatable Bond Count: 1
- Complexity: 448
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 65.4
- XLogP3: 2.7
(Z)-2,3’-Biindolinylidene-2’,3-dione Security Information
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Storage Condition：2-8°C
(Z)-2,3’-Biindolinylidene-2’,3-dione Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | Y08875-1g |
(Z)-[2,3’-Biindolinylidene]-2’,3-dione |
906748-38-7 | 95% | 1g |
￥3829.0 | 2023-09-05 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | Y08875-5g |
(Z)-[2,3’-Biindolinylidene]-2’,3-dione |
906748-38-7 | 95% | 5g |
￥10509.0 | 2023-09-05 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | Y08875-250mg |
(Z)-[2,3’-Biindolinylidene]-2’,3-dione |
906748-38-7 | 95% | 250mg |
￥1939.0 | 2023-09-05 | |
| TRC | H326370-2.5mg |
(Z)-[2,3’-Biindolinylidene]-2’,3-dione |
906748-38-7 | 2.5mg |
$ 70.00 | 2022-06-04 | ||
| TRC | H326370-5mg |
(Z)-[2,3’-Biindolinylidene]-2’,3-dione |
906748-38-7 | 5mg |
$ 95.00 | 2022-06-04 | ||
| TRC | H326370-25mg |
(Z)-[2,3’-Biindolinylidene]-2’,3-dione |
906748-38-7 | 25mg |
$ 340.00 | 2022-06-04 | ||
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | Z920755-5mg |
(Z)-[2,3’-Biindolinylidene]-2’,3-dione |
906748-38-7 | 98% (HPLC) | 5mg |
￥843.30 | 2022-08-31 | |
| abcr | AB527110-250 mg |
(Z)-[2,3'-Biindolinylidene]-2',3-dione; . |
906748-38-7 | 250MG |
€278.00 | 2022-07-29 | ||
| abcr | AB527110-1 g |
(Z)-[2,3'-Biindolinylidene]-2',3-dione; . |
906748-38-7 | 1g |
€503.00 | 2022-07-29 | ||
| Key Organics Ltd | CS-12423-0.25g |
(Z)-[2,3′-Biindolinylidene]-2′,3-dione |
906748-38-7 | >95% | 0.25g |
￡264.00 | 2025-02-08 |
(Z)-2,3’-Biindolinylidene-2’,3-dione Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Sodium carbonate Solvents: Methanol ; 2 h, 22 °C
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Triethylamine , Sodium sulfate Solvents: Isopropanol , Tetrahydrofuran ; 51 h, 30 °C
Reference
- Syntheses of indirubins by aldol condensation of isatins with indoxyl anion generated in situ by lipase-catalyzed deacetylation of indoxyl acetateSugai, Takeshi; Hanaya, Kengo; Higashibayashi, Shuhei, Heterocycles, 2020, 100(1), 129-136
Production Method 3
Reaction Conditions
1.1 Reagents: Sodium carbonate Solvents: Methanol ; 2 - 3 h, rt
Reference
- Discovery of orally active indirubin-3'-oxime derivatives as potent type 1 FLT3 inhibitors for acute myeloid leukemiaJeong, Pyeonghwa; Moon, Yeongyu; Lee, Je-Heon; Lee, So-Deok; Park, Jiyeon; et al, European Journal of Medicinal Chemistry, 2020, 195,
Production Method 4
Reaction Conditions
1.1 Reagents: Sodium carbonate Solvents: Methanol ; 22 h, rt
Reference
- Design, synthesis and biological evaluation of bisindole derivatives as anticancer agents against Tousled-like kinasesLee, Sung-Bau; Chang, Ting-Yu; Lee, Nian-Zhe ; Yu, Zih-Yao; Liu, Chi-Yuan; et al, European Journal of Medicinal Chemistry, 2022, 227,
Production Method 5
Reaction Conditions
1.1 Reagents: Sodium carbonate Solvents: Methanol ; 48 h, rt
Reference
- Acylideneoxoindoles: A new class of reversible inhibitors of human transglutaminase 2Kloeck, Cornelius; Jin, Xi; Choi, Kihang; Khosla, Chaitan; Madrid, Peter B.; et al, Bioorganic & Medicinal Chemistry Letters, 2011, 21(9), 2692-2696
Production Method 6
Reaction Conditions
1.1 Solvents: Tetrahydrofuran ; 2 h, reflux
Reference
- The behaviour of bis(diphenylphosphino)alkanes towards different active centresEwies, Ewies F.; El-Sayed, Naglaa F.; Boulos, Leila S., Journal of Chemical Research, 2016, 40(7), 417-421
Production Method 7
Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Methanol ; 5 h, rt
Reference
- A theoretical and spectroscopic (NMR and IR) study of indirubin in solution and in the solid stateAlkorta, Ibon ; Elguero, Jose ; Dardonville, Christophe ; Reviriego, Felipe ; Santa Maria, Dolores; et al, Journal of Physical Organic Chemistry, 2020, 33(4),
Production Method 8
Reaction Conditions
1.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Solvents: Acetonitrile , Water ; 16 h, rt
Reference
- Formation of tryptanthrin compounds upon Oxone-induced dimerization of indole-3-carbaldehydesNelson, Amber C.; Kalinowski, Emily S.; Jacobson, Taylor L.; Grundt, Peter, Tetrahedron Letters, 2013, 54(50), 6804-6806
(Z)-2,3’-Biindolinylidene-2’,3-dione Raw materials
(Z)-2,3’-Biindolinylidene-2’,3-dione Preparation Products
(Z)-2,3’-Biindolinylidene-2’,3-dione Related Literature
-
Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
-
Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
-
Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
-
Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
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