Production Method 1

25574-11-2

90562-10-0

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  5 min, rt
1.2 Reagents: Methanesulfonyl chloride ;  1 h, rt
1.3 Reagents: Methylmagnesium bromide Solvents: Diethyl ether ,  Toluene ;  rt; 1 h, rt
1.4 Reagents: Methanol ;  rt

Reference

Halogenation Reactions of Alkyl Alcohols Employing Methyl Grignard Reagents

Hirbawi, Nadia ; Lin, Patricia C. ; Jarvo, Elizabeth R., Journal of Organic Chemistry, 2022, 87(18), 12352-12369

Production Method 2

1643-30-7

90562-10-0

Reaction Conditions

1.1 Reagents: (Dimethyl sulfide)trihydroboron Solvents: Tetrahydrofuran ;  0 °C; 18 h, rt
1.2 Reagents: Water ;  rt
1.3 Reagents: Carbon tetrabromide ,  Triphenylphosphine Solvents: Dichloromethane ;  0 °C; 18 h, rt
1.4 Reagents: Sodium chloride Solvents: Water ;  rt

Reference

Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity

Yamashita, Yasunobu; Tanaka, Ken-ichiro; Yamakawa, Naoki; Asano, Teita; Kanda, Yuki; et al, Bioorganic & Medicinal Chemistry, 2019, 27(15), 3339-3346

Production Method 3

25574-11-2

90562-10-0

Reaction Conditions

1.1 Reagents: Carbon tetrabromide ,  Triphenylphosphine Solvents: Tetrahydrofuran ;  15 min, 0 °C; 15 min, rt

Reference

Development of Prodrug 4-Chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl Benzoate (TG100801): A Topically Administered Therapeutic Candidate in Clinical Trials for the Treatment of Age-Related Macular Degeneration

Palanki, Moorthy S. S.; Akiyama, Hideo; Campochiaro, Peter; Cao, Jianguo; Chow, Chun P.; et al, Journal of Medicinal Chemistry, 2008, 51(6), 1546-1559

Production Method 4

25574-11-2

90562-10-0

Reaction Conditions

1.1 Reagents: Carbon tetrabromide ,  Triphenylphosphine Solvents: Tetrahydrofuran ;  0 °C; 4 h, rt

Reference

Syntheses and evaluation of a homologous series of aza-vesamicol as improved radioiodine-labeled probes for sigma-1 receptor imaging

Ogawa, Kazuma ; Masuda, Ryohei; Mishiro, Kenji; Wang, Mengfei; Kozaka, Takashi; et al, Bioorganic & Medicinal Chemistry, 2019, 27(10), 1990-1996

Production Method 5

25574-11-2

90562-10-0

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Tetrahydrofuran ;  heated

Reference

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-substituted phenyl alkyl triazole-based compounds as potential inhibitors of 17α-hydroxylase/17,20-lyase (P45017α)

Owen, Caroline P.; Dhanani, Sachin; Patel, Chirag H.; Ahmed, Sabbir, Letters in Drug Design & Discovery, 2007, 4(7), 479-483

Production Method 6

25574-11-2

90562-10-0

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide ,  Triphenylphosphine Solvents: Dichloromethane ;  60 min, 0 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Mo-Based Oxidizers as Powerful Tools for the Synthesis of Thia- and Selenaheterocycles

Franzmann, Peter; Beil, Sebastian B. ; Schollmeyer, Dieter; Waldvogel, Siegfried R., Chemistry - A European Journal, 2019, 25(8), 1936-1940

Production Method 7

1124-14-7

90562-10-0

Reaction Conditions

1.1 Reagents: tert-Butanol ,  Boron tribromide Solvents: Dichloromethane ;  25 h, 22 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  0 °C

Reference

Boron tribromide as a reagent for anti-Markovnikov addition of HBr to cyclopropanes

Gieuw, Matthew H.; Chen, Shuming; Ke, Zhihai; Houk, K. N.; Yeung, Ying-Yeung, Chemical Science, 2020, 11(35), 9426-9433

Production Method 8

25574-11-2

90562-10-0

Reaction Conditions

1.1 Reagents: Carbon tetrabromide ,  Triphenylphosphine Solvents: Tetrahydrofuran ;  15 min, 0 °C; 8 h, rt

Reference

Nickel-Catalyzed Cross-Coupling of Potassium Aryl- and Heteroaryltrifluoroborates with Unactivated Alkyl Halides

Molander, Gary A.; Argintaru, O. Andreea; Aron, Ioana; Dreher, Spencer D., Organic Letters, 2010, 12(24), 5783-5785

Production Method 9

25574-11-2

90562-10-0

Reaction Conditions

1.1 Reagents: Carbon tetrabromide ,  Triphenylphosphine Solvents: Dichloromethane ;  0 °C; 0 °C → 25 °C; 3 h, 25 °C

Reference

Selective Piperidine Synthesis Exploiting Iodine-Catalyzed Csp3-H Amination under Visible Light

Zhang, Hongwei; Muniz, Kilian, ACS Catalysis, 2017, 7(6), 4122-4125

Production Method 10

40640-98-0

90562-10-0

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride
1.2 Reagents: Carbon tetrabromide ,  Triphenylphosphine

Reference

4-Alkyloxyimino Derivatives of Uridine-5'-triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y2, P2Y4, and P2Y6 Receptors

Jayasekara, P. Suresh; Barrett, Matthew O.; Ball, Christopher B.; Brown, Kyle A.; Hammes, Eva; et al, Journal of Medicinal Chemistry, 2014, 57(9), 3874-3883

Production Method 11

1200-07-3

90562-10-0

Reaction Conditions

1.1 Reagents: Ethanol ,  Hydrogen ion ;  reflux
1.2 Reagents: Hydrogen Catalysts: Palladium
1.3 Reagents: Oxygen Solvents: Tetrahydrofuran ;  reflux
1.4 Reagents: Phosphorus tribromide Solvents: Diethyl ether ;  reflux

Reference

Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17α-Hydroxylase/17,20-Lyase (P45017α)

Shahid, Imran; Patel, Chirag H.; Dhanani, Sachin; Owen, Caroline P.; Ahmed, Sabbir, Journal of Steroid Biochemistry and Molecular Biology, 2008, 110(1-2), 18-29

Production Method 12

25574-11-2

90562-10-0

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Tetrahydrofuran ;  reflux

Reference

Synthesis, biochemical evaluation and rationalization of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17α-hydroxylase/17,20-lyase (P45017α)

Patel, Chirag H.; Dhanani, Sachin; Owen, Caroline P.; Ahmed, Sabbir, Bioorganic & Medicinal Chemistry Letters, 2006, 16(18), 4752-4756

1-Bromo-4-(3-bromopropyl)benzene Raw materials

• 3-(4-Bromophenyl)propan-1-ol
• 1-bromo-4-cyclopropyl-benzene
• 3-(4-bromophenyl)propanoic acid
• 4-Bromocinnamic acid
• Ethyl 3-(4-bromophenyl)propanoate

1-Bromo-4-(3-bromopropyl)benzene Preparation Products

• 1-Bromo-4-(3-bromopropyl)benzene (90562-10-0)

• 1. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 2. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 5. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Bromobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Bromobenzenes

• 588-93-2(1-Bromo-4-propylbenzene)
• 89506-95-6(Benzene, 1-bromo-4-(8-bromooctyl)-)
• 67386-74-7(1-Bromo-4-(4-bromo-2-methylbutyl)benzene)
• 109757-61-1(1-bromo-3-(3-bromo-propyl)-benzene)
• 909551-10-6(Benzene, 1-bromo-4-(10-bromodecyl)-)
• 19829-56-2(1-Bromo-4-2-(4-bromophenyl)ethylbenzene)
• 14310-24-8(Benzene,1-bromo-4-(2-phenylethyl)-)
• 107396-49-6(Benzene, 1-bromo-4-(5-bromohexyl)-)
• 1075-28-1(1-bromo-2-(3-bromopropyl)benzene)
• 88999-91-1(Benzene, 1-bromo-4-(4-bromobutyl)-)