Production Method 1

905587-42-0

905587-41-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol

Reference

Use of Immobilized Amine Transaminase from Vibrio fluvialis under Flow Conditions for the Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)-ethanamine

Semproli, Riccardo; Vaccaro, Gianmarco; Ferrandi, Erica E. ; Vanoni, Marta; Bavaro, Teodora ; et al, ChemCatChem, 2020, 12(5), 1359-1367

Production Method 2

905587-42-0

905587-41-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  3 h, 18 - 25 °C

Reference

Discovery of 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway

Ioannidis, Stephanos; Lamb, Michelle L.; Wang, Tao; Almeida, Lynsie; Block, Michael H.; et al, Journal of Medicinal Chemistry, 2011, 54(1), 262-276

Production Method 3

905587-44-2

905587-41-9

Reaction Conditions

1.1 Reagents: Ammonium acetate ,  Sodium cyanoborohydride Solvents: Methanol ;  24 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 10, rt

Reference

Direct Asymmetric Reductive Amination of Alkyl (Hetero)Aryl Ketones by an Engineered Amine Dehydrogenase

Kong, Weixi; Liu, Yunting; Huang, Chen; Zhou, Liya; Gao, Jing; et al, Angewandte Chemie, 2022, 61(21),

1-(5-fluoropyrimidin-2-yl)ethan-1-amine Raw materials

• 1-(5-fluoropyrimidin-2-yl)ethan-1-one
• 2-(1-Azidoethyl)-5-fluoropyrimidine

1-(5-fluoropyrimidin-2-yl)ethan-1-amine Preparation Products

• 1-(5-fluoropyrimidin-2-yl)ethan-1-amine (905587-41-9)

• 1. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 2. Distinct roles of SNARE-mimicking lipopeptides during initial steps of membrane fusion?
  Alena Koukalová,?árka Pokorná,Aimee L. Boyle,Nestor Lopez Mora,Alexander Kros,Martin Hof,Radek ?achl Nanoscale, 2018,10, 19064-19073
• 3. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 4. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 5. Enantiomorphic symmetry breaking in crystallization of molten sodium chlorate?
  Martin R. Ward,Gary W. Copeland,Andrew J. Alexander Chem. Commun., 2010,46, 7634-7636

• 935667-21-3((1S)-1-(5-fluoropyrimidin-2-yl)ethanamine hydrochloride)
• 944906-24-5(1-(pyrimidin-2-yl)ethan-1-amine)
• 1314394-77-8((5-Fluoropyrimidin-2-yl)methanamine hydrochloride)
• 1414958-45-4(1-(5-Fluoropyrimidin-2-yl)ethan-1-amine hydrochloride)
• 1196155-99-3((5-fluoropyrimidin-2-yl)methanamine)
• 1616809-52-9(1-pyrimidin-2-ylethanamine;hydrochloride)
• 2138337-19-4(1-(pyrimidin-2-yl)ethan-1-amine dihydrochloride)
• 1373223-30-3(C-(5-Fluoro-pyrimidin-2-yl)-methylamine dihydrochloride)
• 1202070-40-3((R)-1-(5-Fluoropyrimidin-2-yl)ethan-1-amine Hydrochloride)
• 905587-29-3((1S)-1-(5-fluoropyrimidin-2-yl)ethan-1-amine)