Production Method 1

94616-84-9

2243-82-5

90299-04-0

Reaction Conditions

1.1 Solvents: Tetrahydrofuran
1.2 Reagents: Ammonium hydroxide Solvents: Water

Reference

Organocerium reactions of benzamides and thiobenzamides: a direct synthesis of tertiary carbinamines

Calderwood, David J.; Davies, Roy V.; Rafferty, Paul; Twigger, Helen L.; Whelan, Helen M., Tetrahedron Letters, 1997, 38(7), 1241-1244

Production Method 2

613-46-7

90299-04-0

Reaction Conditions

1.1 Solvents: 2-Methyltetrahydrofuran ,  Tetrahydrofuran ;  30 min, rt
1.2 Reagents: Titanium isopropoxide ;  overnight, rt → 50 °C; 50 °C → rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  15 min, rt
1.4 Reagents: Hydrochloric acid Solvents: Water ;  rt
1.5 Reagents: Sodium hydroxide Solvents: Water ;  rt

Reference

Dual Copper- and Aldehyde-Catalyzed Transient C-H Sulfonylation of Benzylamines

Higham, Joe I.; Ma, Tsz-Kan ; Bull, James A., Organic Letters, 2023, 25(28), 5285-5290

Production Method 3

2459-25-8

90299-04-0

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Diethyl ether ;  15 min, rt
1.2 rt; 1 h, reflux; reflux → 0 °C; 0 °C; 4 - 5 h, 0 °C
1.3 Reagents: Sodium azide Solvents: Dichloromethane ;  rt → -5 °C; -5 °C; 15 min, -5 °C; 1 - 2 h, 0 °C
1.4 Reagents: Ammonium hydroxide Solvents: Water ;  0 °C; 30 min, 0 °C
1.5 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  0 °C; 3 - 4 h, rt
1.6 Reagents: Sodium hydroxide Solvents: Water ;  rt

Reference

Native Amine-Directed ortho-C-H Halogenation and Acetoxylation /Condensation of Benzylamines

Chand-Thakuri, Pratibha; Alahakoon, Indunil; Liu, Daniel; Kapoor, Mohit; Kennedy, John F.; et al, Synthesis, 2022, 54(2), 341-354

Production Method 4

613-46-7

917-54-4

90299-04-0

Reaction Conditions

1.1 Reagents: Cerium trichloride Solvents: Tetrahydrofuran ;  -78 °C; 30 min, -78 °C
1.2 Solvents: Tetrahydrofuran ;  -78 °C; overnight, rt
1.3 Reagents: Ammonium hydroxide Solvents: Water ;  1 h, rt

Reference

Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agent

Gallardo-Macias, Ricardo; Kumar, Pradeep; Jaskowski, Mark; Richmann, Todd; Shrestha, Riju; et al, Bioorganic & Medicinal Chemistry Letters, 2019, 29(4), 601-606

2-(naphthalen-2-yl)propan-2-amine Raw materials

• naphthalene-2-carbonitrile
• Methyl 2-naphthoate
• Cerium, dichloromethyl-
• Methyllithium (1.6M in Diethyl Ether)
• Naphthalene-2-carboxamide

2-(naphthalen-2-yl)propan-2-amine Preparation Products

• 2-(naphthalen-2-yl)propan-2-amine (90299-04-0)

• 1. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 2. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 5. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090

• Solvents and Organic Chemicals Organic Compounds Benzenoids Naphthalenes Naphthalenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Naphthalenes

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