Production Method 1

91-16-7

90282-99-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ,  Hexane ;  rt; 48 h, rt
1.2 Reagents: Triethylamine Solvents: Diethyl ether ;  10 min, rt
1.3 Reagents: Trifluoromethanesulfonyl chloride ;  rt; 1 h, rt
1.4 Reagents: Water ;  rt

Reference

Halogenated volatiles from the fungus Geniculosporium and the actinomycete Streptomyces chartreusis

Wang, Tao; Rabe, Patrick; Citron, Christian A.; Dickschat, Jeroen S., Beilstein Journal of Organic Chemistry, 2013, 9, 2767-2777

Production Method 2

91-16-7

90282-99-8

Reaction Conditions

1.1 Reagents: sec-Butyllithium Solvents: Tetrahydrofuran ,  Cyclohexane ;  1 h, -78 °C
1.2 Reagents: Hexachloroethane Solvents: Tetrahydrofuran ;  -78 °C; 2 h, -78 °C → rt
1.3 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

Modular Synthesis of Halogenated Xanthones by a Divergent Coupling Strategy

Meringdal, Jonas W.; Kilian, Alexander; Li, Wingkee C.; Heinemann, Maximilian J. B.; Rausch, Marvin; et al, Journal of Organic Chemistry, 2022, 87(14), 9375-9383

Production Method 3

91-16-7

90282-99-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ;  3 d, rt
1.2 Reagents: Carbon tetrachloride ;  rt
1.3 Reagents: Water ;  rt

Reference

Photoreduction and photosubstitution of haloanisoles

Siegman, John Robert, 1981, , ,

Production Method 4

91-16-7

90282-99-8

16766-27-1

Reaction Conditions

1.1 Reagents: Potassium chloride ,  Hydrogen peroxide Solvents: Acetic acid

Reference

Oxyhalogenation of aromatic compounds in presence of KCl or KBr and H2O2 over zeolites

Narender, N.; Srinivasu, P.; Kulkarni, S. J.; Raghavan, K. V., Studies in Surface Science and Catalysis, 2001, 135, 3745-3750

1-Chloro-2,3-dimethoxybenzene Raw materials

• Veratrole

1-Chloro-2,3-dimethoxybenzene Preparation Products

• 1-Chloro-2,3-dimethoxybenzene (90282-99-8)
• 4-Chloro-1,2-dimethoxybenzene (16766-27-1)

• 1. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 2. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 3. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 4. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 5. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Dimethoxybenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Methoxybenzenes Dimethoxybenzenes

1-Chloro-2,3-Dimethoxybenzene: A Comprehensive Overview

1-Chloro-2,3-Dimethoxybenzene, also known by its CAS number CAS No. 90282-99-8, is a versatile aromatic compound with significant applications in various fields of chemistry. This compound is characterized by its benzene ring substituted with a chlorine atom at position 1 and methoxy groups at positions 2 and 3. The presence of these substituents imparts unique chemical and physical properties to the molecule, making it a valuable intermediate in organic synthesis and a key component in numerous industrial processes.

The synthesis of 1-Chloro-2,3-Dimethoxybenzene typically involves the chlorination of resorcinol derivatives under controlled conditions. Recent advancements in catalytic methods have enabled more efficient and selective synthesis pathways, reducing production costs and minimizing environmental impact. These developments have been documented in several peer-reviewed journals, highlighting the compound's potential for large-scale production.

In terms of chemical properties, 1-Chloro-2,3-Dimethoxybenzene exhibits strong electron-donating effects due to the methoxy groups, which influence its reactivity in various reactions. For instance, the compound is widely used as an intermediate in the preparation of pharmaceuticals, agrochemicals, and advanced materials. Its ability to undergo nucleophilic aromatic substitution reactions makes it particularly useful in synthesizing complex molecules with high precision.

Recent studies have explored the application of 1-Chloro-2,3-Dimethoxybenzene in the field of materials science. Researchers have demonstrated its potential as a precursor for the synthesis of conductive polymers and organic semiconductors. These findings have opened new avenues for its use in electronic devices such as organic light-emitting diodes (OLEDs) and flexible electronics.

The compound's stability under thermal and oxidative conditions has also been a subject of interest. Advanced spectroscopic techniques have been employed to study its degradation pathways, providing insights into its long-term storage and handling requirements. These studies underscore the importance of proper storage conditions to maintain the compound's integrity and functionality.

In conclusion, 1-Chloro-2,3-Dimethoxybenzene (CAS No. 90282-99-8) remains a critical component in modern chemistry due to its diverse applications and unique chemical properties. Ongoing research continues to uncover new opportunities for its use across various industries, solidifying its position as an essential compound in contemporary chemical research and development.

• 77241-44-2(Benzene,chlorotrimethoxy- (9CI))
• 90283-02-6(Benzene,1,4-dichloro-2,3-dimethoxy-)
• 77102-92-2(3-chloro-2-methoxyphenol)
• 77102-93-3(Phenol,3,6-dichloro-2-methoxy-)
• 90283-00-4(Benzene,1,2-dichloro-3,4-dimethoxy-)
• 90283-01-5(Benzene,1,5-dichloro-2,3-dimethoxy-)
• 56680-89-8(3,5-dichloro-2-methoxyphenol)
• 54625-53-5(Benzene,1-chloro-2,3,4-trimethoxy-)
• 18113-22-9( )
• 77102-94-4(Phenol,3,4-dichloro-2-methoxy-)