Production Method 1

414868-41-0

90226-87-2

Reaction Conditions

1.1 Reagents: Hydrogen Solvents: Ethanol ,  Water

Reference

Antihypertensive agents. III. Dialkylaminoalkoxypiperidines and related compounds

Shapiro, Seymour L.; Soloway, Harold; Shapiro, Harris J.; Freedman, Louis, Journal of Organic Chemistry, 1960, 25, 291-3

(1-Ethylpiperidin-4-YL)methanol Raw materials

• 1-Ethyl-4-(hydroxymethyl)pyridin-1-ium

(1-Ethylpiperidin-4-YL)methanol Preparation Products

• (1-Ethylpiperidin-4-YL)methanol (90226-87-2)

• 1. An investigation on the second-order nonlinear optical response of cationic bipyridine or phenanthroline iridium(iii) complexes bearing cyclometallated 2-phenylpyridines with a triphenylamine substituent?
  David B. Cordes,Alexandra M. Z. Slawin,Stefania Righetto,Denis Jacquemin,Eli Zysman-Colman,Véronique Guerchais Dalton Trans., 2018,47, 8292-8300
• 2. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 3. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 4. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 5. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Comprehensive Overview of (1-Ethylpiperidin-4-YL)methanol (CAS No. 90226-87-2): Properties, Applications, and Industry Insights

(1-Ethylpiperidin-4-YL)methanol (CAS No. 90226-87-2) is a versatile organic compound with a growing presence in pharmaceutical and chemical research. Its molecular structure, featuring a piperidine ring substituted with an ethyl group and a hydroxymethyl moiety, makes it a valuable intermediate in synthetic chemistry. This compound has garnered attention due to its potential applications in drug discovery, particularly in the development of central nervous system (CNS) therapeutics and enzyme inhibitors.

In recent years, the demand for piperidine derivatives like (1-Ethylpiperidin-4-YL)methanol has surged, driven by advancements in medicinal chemistry and high-throughput screening. Researchers are increasingly exploring its role in modulating neurotransmitter receptors, a hot topic in neurological disorder research. The compound’s lipophilicity and hydrogen-bonding capacity contribute to its bioavailability, a critical factor in drug design optimization.

The synthesis of 90226-87-2 typically involves reductive amination or N-alkylation strategies, with yields optimized through catalytic hydrogenation. Its purity is often verified via HPLC and NMR spectroscopy, ensuring compliance with Good Manufacturing Practices (GMP). These analytical techniques are frequently searched by professionals seeking quality control protocols for pharmaceutical intermediates.

Beyond pharmaceuticals, (1-Ethylpiperidin-4-YL)methanol finds utility in agrochemical formulations and material science. Its derivatization into ionic liquids has been studied for green chemistry applications, aligning with the global push for sustainable solvents. This aligns with trending searches on eco-friendly chemical alternatives and biodegradable additives.

Safety profiles of CAS 90226-87-2 emphasize proper handling under fume hoods and personal protective equipment (PPE), topics frequently queried in laboratory safety databases. Regulatory status varies by region, but it generally falls under standard industrial chemical classifications.

Future research directions for (1-Ethylpiperidin-4-YL)methanol include its potential in chiral synthesis and catalysis, areas dominating organic chemistry forums. As AI-driven molecular modeling accelerates discovery, this compound’s structure-activity relationships (SAR) remain a key focus for computational chemists.

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