- Microwave hydrogenations: large-size, high pressure microwave reactorHeller, Eberhard; Gutmann, Amelie; Hiltensperger, Georg; Lautenschlaeger, Werner; Lohse, Martin J.; et al, G.I.T. Laboratory Journal, 2013, 17(1-2), 32-33
Cas no 90071-62-8 (tert-butyl (2R)-pyrrolidine-2-carboxylate)
Tert-butyl (2R)-pyrrolidine-2-carboxylate is a chiral pyrrolidine derivative widely utilized as a key intermediate in organic synthesis and pharmaceutical applications. Its tert-butyl ester group enhances stability and facilitates selective deprotection under mild conditions, making it valuable for peptide and heterocycle synthesis. The (2R)-configuration ensures stereochemical precision, which is critical for asymmetric synthesis and the development of enantiomerically pure compounds. This compound is particularly useful in the preparation of bioactive molecules, including protease inhibitors and other pharmacologically active agents. Its high purity and well-defined stereochemistry make it a reliable building block for research and industrial-scale applications.
90071-62-8 structure
Product Name:tert-butyl (2R)-pyrrolidine-2-carboxylate
CAS No:90071-62-8
MF:C9H17NO2
MW:171.23678278923
MDL:MFCD00083683
CID:803649
PubChem ID:6931635
Update Time:2025-06-08
tert-butyl (2R)-pyrrolidine-2-carboxylate Chemical and Physical Properties
Names and Identifiers
-
- (R)-tert-Butyl pyrrolidine-2-carboxylate
- D-Proline tert-Butyl Ester
- D-Proline t-butyl ester
- D-PROLINE T-BUTYL ESTER HYDROCHLORIDE,
- D-Proline,1,1-dimethylethyl ester
- D-PROLINE-OTBU
- H-D-PRO-OTBU
- H-D-Pro-OtBu(syrup)
- H-D-Pro-OtBu.HCl
- H-d-pro-otbuhcl
- (R)-Pyrrolidine-2-carboxylic acid tert-butyl ester
- D-Proline, 1,1-dimethylethyl ester
- tert-butyl (2R)-pyrrolidine-2-carboxylate
- H-Pro-OtBu
- tert-butyl D-prolinate
- h-D-pro-otbu, AldrichCPR
- 1,1-dimethylethyl D-prolinate
- KM2898
- 2-Methyl-2-propanyl D-prolinate
- 2-Methyl-2-propanyl-D-prolinat
- D-Prolinate de 2-méthyl-2-propanyle
- H-D-Pro-OtBu (syrup)
- H-D-Pro-OtBu · HCl
- L-Proline tert-butyl ester; (2S)-2-(tert-Butoxycarbonyl)pyrrolidine
- SS-9688
- tert-butyl (2S)-pyrrolidine-2-carboxylate
- D-Proline 1,1-dimethylethyl ester (ACI)
- H-D-Pro-OBu-t
- tert-Butyl (R)-pyrrolidine-2-carboxylate
-
- MDL： MFCD00083683
- Inchi： 1S/C9H17NO2/c1-9(2,3)12-8(11)7-5-4-6-10-7/h7,10H,4-6H2,1-3H3/t7-/m1/s1
- InChI Key： XJJBXZIKXFOMLP-SSDOTTSWSA-N
- SMILES： C([C@@H]1NCCC1)(=O)OC(C)(C)C
Computed Properties
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 12
- Rotatable Bond Count: 3
- Complexity: 172
- XLogP3: 1.1
- Topological Polar Surface Area: 38.3
Experimental Properties
- Density: 0.995±0.06 g/cm3 (20 oC 760 Torr),
- Boiling Point: 219.2±33.0 oC (760 Torr),
- Flash Point: 86.4±25.4 oC,
- Solubility: Slightly soluble (16 g/l) (25 o C),
tert-butyl (2R)-pyrrolidine-2-carboxylate Security Information
- Hazard Category Code： 22-37/38-41-51
- Safety Instruction： 26-39
-
Hazardous Material Identification：
tert-butyl (2R)-pyrrolidine-2-carboxylate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM304051-5g |
H-D-Pro-OtBu |
90071-62-8 | 95% | 5g |
$297 | 2021-06-09 | |
| TRC | P755875-500mg |
D-Proline tert-Butyl Ester |
90071-62-8 | 500mg |
$207.00 | 2023-05-17 | ||
| TRC | P755875-2.5g |
D-Proline tert-Butyl Ester |
90071-62-8 | 2.5g |
$ 655.00 | 2022-06-03 | ||
| Apollo Scientific | OR964379-250mg |
H-D-Pro-otbu |
90071-62-8 | 98% | 250mg |
￡110.00 | 2024-05-23 | |
| Apollo Scientific | OR964379-1g |
H-D-Pro-otbu |
90071-62-8 | 98% | 1g |
￡200.00 | 2024-05-23 | |
| abcr | AB314224-1 g |
H-D-Pro-OtBu; 95% |
90071-62-8 | 1 g |
€110.00 | 2023-07-19 | ||
| abcr | AB314224-5 g |
H-D-Pro-OtBu; 95% |
90071-62-8 | 5 g |
€297.00 | 2023-07-19 | ||
| abcr | AB314224-10 g |
H-D-Pro-OtBu; 95% |
90071-62-8 | 10 g |
€518.00 | 2023-07-19 | ||
| abcr | AB314224-25 g |
H-D-Pro-OtBu; 95% |
90071-62-8 | 25 g |
€858.00 | 2023-07-19 | ||
| Fluorochem | 209560-1g |
H-D-Pro-Otbu |
90071-62-8 | 95% | 1g |
￡43.00 | 2022-02-28 |
tert-butyl (2R)-pyrrolidine-2-carboxylate Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Hydrogen Solvents: Methanol ; 10 min, 10 bar, 80 °C
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Trifluoroacetic acid Solvents: Ethanol , Water ; 1 h, rt
1.2 Reagents: Hydrogen Catalysts: Palladium ; 24 h, 40 °C
1.3 Reagents: Sodium bicarbonate Solvents: Water ; basified
1.2 Reagents: Hydrogen Catalysts: Palladium ; 24 h, 40 °C
1.3 Reagents: Sodium bicarbonate Solvents: Water ; basified
Reference
- Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylationKano, Taichi; Kumano, Takeshi; Sakamoto, Ryu; Maruoka, Keiji, Organic & Biomolecular Chemistry, 2013, 11(2), 271-278
tert-butyl (2R)-pyrrolidine-2-carboxylate Raw materials
- 1,2-Pyrrolidinedicarboxylicacid, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester,(2R)-
- 1,3-Dioxolane-2-butanoic acid, α-[(diphenylmethylene)amino]-, 1,1-dimethylethyl ester, (αR)-
tert-butyl (2R)-pyrrolidine-2-carboxylate Preparation Products
tert-butyl (2R)-pyrrolidine-2-carboxylate Suppliers
Amadis Chemical Company Limited
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Audited Supplier
(CAS:90071-62-8)tert-butyl (2R)-pyrrolidine-2-carboxylate
Order Number:A860914
Stock Status:in Stock
Quantity:25g/10g/5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 08:26
Price ($):508.0/307.0/176.0
Email:[email protected]
tert-butyl (2R)-pyrrolidine-2-carboxylate Related Literature
-
Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
-
Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
-
Jason Wan Lab Chip, 2020,20, 4528-4538
-
Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
-
Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
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Recommended suppliers
Amadis Chemical Company Limited
(CAS:90071-62-8)tert-butyl (2R)-pyrrolidine-2-carboxylate
Purity:99%/99%/99%
Quantity:25g/10g/5g
Price ($):508.0/307.0/176.0