Production Method 1

93-02-7

90064-47-4

Reaction Conditions

1.1 Reagents: Iodine ,  Silver nitrate Solvents: Methanol ;  overnight, rt

Reference

Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs

Cunningham, Michael J.; Bock, Hailey A.; Serrano, Inis C.; Bechand, Benjamin; Vidyadhara, D. J.; et al, ACS Chemical Neuroscience, 2023, 14(1), 119-135

Production Method 2

93-02-7

90064-47-4

Reaction Conditions

1.1 Reagents: Iodine ,  Silver nitrate Solvents: Methanol ;  12 h, rt
1.2 Reagents: Sodium thiosulfate Solvents: Water ;  rt

Reference

Effect of Conjugation Mode on Intramolecular Charge Transfer in Fabricating Acid-Responsive Fluorophores

Wang, Rong; Ding, Ju; Wang, Yuxiu; Zhang, Yanrong, Chemistry - An Asian Journal, 2019, 14(21), 3883-3892

Production Method 3

93-02-7

90064-47-4

Reaction Conditions

1.1 Reagents: Iodine ,  Silver nitrate Solvents: Methanol ;  overnight, rt

Reference

Comparison of iodination of methoxylated benzaldehydes and related compounds using iodine/silver nitrate and iodine/periodic acid

Hathaway, Bruce A.; White, Kristen L.; McGill, Mark E., Synthetic Communications, 2007, 37(21), 3855-3860

Production Method 4

51560-21-5

90064-47-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ,  Hexane ;  20 min, -10 °C; 1 h, -8 - -5 °C
1.2 6 h, -5 °C → rt

Reference

Alkyloxy substituted organic dyes for high voltage dye-sensitized solar cell: Effect of alkyloxy chain length on open-circuit voltage

Ko, Soo-Byung; Cho, An-Na; Kim, Mi-Jeong; Lee, Chang-Ryul; Park, Nam-Gyu, Dyes and Pigments, 2012, 94(1), 88-98

Production Method 5

93-02-7

90064-47-4

Reaction Conditions

1.1 Reagents: Iodine ,  Silver nitrate Solvents: Methanol ;  rt

Reference

Detection of Amines with Extended Distyrylbenzenes by Strip Assays

Kumpf, Jan; Freudenberg, Jan; Fletcher, Katharyn; Dreuw, Andreas; Bunz, Uwe H. F., Journal of Organic Chemistry, 2014, 79(14), 6634-6645

Production Method 6

51560-21-5

90064-47-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ,  Hexane ;  0 °C
1.2 Solvents: Diethyl ether ;  3 h, rt
1.3 Reagents: Water

Reference

Chromogenic meroterpenoids from the mushrooms Russula ochroleuca and R. Viscida

Sontag, Bernd; Rueth, Matthias; Spiteller, Peter; Arnold, Norbert; Steglich, Wolfgang; et al, European Journal of Organic Chemistry, 2006, (4), 1023-1033

Production Method 7

93-02-7

90064-47-4

Reaction Conditions

1.1 Reagents: Iodine ,  Silver nitrate Solvents: Methanol

Reference

Study of Supramolecular Side-Chain Copolymers Containing Light-Emitting H-Acceptors and Electron-Transporting Dendritic H-Donors

Yang, Po-Jen; Wu, Chung-Wen; Sahu, Duryodhan; Lin, Hong-Cheu, Macromolecules (Washington, 2008, 41(24), 9692-9703

Production Method 8

93-02-7

90064-47-4

Reaction Conditions

1.1 Reagents: Iodine ,  Silver nitrate Solvents: Methanol ;  overnight, rt

Reference

Palladium mediated intramolecular multiple C-X/C-H cross coupling and C-H activation: synthesis of carbazole alkaloids calothrixin B and murrayaquinone A

Kaliyaperumal, Srinivasan A.; Banerjee, Shyamapada; U. K., Syam Kumar, Organic & Biomolecular Chemistry, 2014, 12(32), 6105-6113

Production Method 9

93-02-7

90064-47-4

Reaction Conditions

1.1 Reagents: Iodine Solvents: Methanol

Reference

Selective preparation of 4-(bromo or iodo)-2,5-dimethoxybenzonitrile and 2-(bromo or iodo)-3,6-dimethoxybenzonitrile from 2,5-dimethoxybenzaldehyde

Hathaway, Bruce A.; Taylor, Brian E.; Wittenborn, Jeremy S., Synthetic Communications, 1998, 28(24), 4629-4637

Production Method 10

51560-21-5

90064-47-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ;  5 min, 0 °C; 10 min, 0 °C
1.2 2 h, rt
1.3 Reagents: Water ;  rt

Reference

Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

Ettrup, Anders; Hansen, Martin; Santini, Martin A.; Paine, James; Gillings, Nic; et al, European Journal of Nuclear Medicine and Molecular Imaging, 2011, 38(4), 681-693

Production Method 11

93-02-7

90064-47-4

Reaction Conditions

1.1 Reagents: Iodine ,  Silver nitrate Solvents: Methanol ;  2 h, rt

Reference

Multiple bond-conjugated photoinduced nitric oxide releaser working with two-photon excitation

Hishikawa, Kazuhiro; Nakagawa, Hidehiko; Furuta, Toshiaki; Fukuhara, Kiyoshi; Tsumoto, Hiroki; et al, Bioorganic & Medicinal Chemistry Letters, 2010, 20(1), 302-305

Production Method 12

93-02-7

90064-47-4

Reaction Conditions

1.1 Reagents: Iodine ,  Silver nitrate Solvents: Methanol ;  7 h

Reference

Synthesis of Poly(Arylene Alkenylene)s by Pd-Catalyzed Three-Component Coupling Polycondensation of Diiodoarenes, Non-Conjugated Dienes, and Nucleophiles that Involves Chain Walking Isomerization

Tan, Liyi; Takeuchi, Daisuke ; Osakada, Kohtaro, Journal of Polymer Science, 2019, 57(24), 2535-2542

Production Method 13

93-02-7

90064-47-4

Reaction Conditions

Reference

Acid-Induced Shift of Intramolecular Hydrogen Bonding Responsible for Excited-State Intramolecular Proton Transfer

Wang, Qin; Niu, Yahui; Wang, Rong; Wu, Haoran; Zhang, Yanrong, Chemistry - An Asian Journal, 2018, 13(13), 1735-1743

Production Method 14

93-02-7

90064-47-4

Reaction Conditions

1.1 Reagents: Iodine ,  Silver nitrate Solvents: Methanol ;  7 h, rt

Reference

High performance organic photosensitizers for dye-sensitized solar cells

Im, Hunbae; Kim, Sukwon; Park, Chanmoo; Jang, Seok-Hoon; Kim, Chang-Ju; et al, Chemical Communications (Cambridge, 2010, 46(8), 1335-1337

4-Iodo-2,5-dimethoxybenzaldehyde Raw materials

• 1,4-Diiodo-2,5-dimethoxybenzene
• 2,5-Dimethoxybenzaldehyde

4-Iodo-2,5-dimethoxybenzaldehyde Preparation Products

• 4-Iodo-2,5-dimethoxybenzaldehyde (90064-47-4)

• 1. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 2. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 3. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 4. An amorphous lanthanum–iridium solid solution with an open structure for efficient water splitting?
  Wei Sun,Chenglong Ma,Xinlong Tian,Jianjun Liao,Ji Yang,Chengjun Ge,Weiwei Huang J. Mater. Chem. A, 2020,8, 12518-12525
• 5. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
  R. M. Pemberton,J. P. Hart,T. T. Mottram Analyst, 2001,126, 1866-1871

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Dimethoxybenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Methoxybenzenes Dimethoxybenzenes

• 42298-41-9(5-Iodo-2-methoxybenzaldehyde)
• 139102-37-7(4-iodo-2-methoxybenzaldehyde)
• 135242-70-5(Benzaldehyde, 2,5-dihydroxy-3-iodo-)
• 32024-13-8(3,5-diiodo-2-methoxybenzaldehyde)
• 190131-55-6(Benzaldehyde, 2,5-bis(hexyloxy)-4-iodo-)
• 186358-39-4(Benzaldehyde, 4-iodo-2,5-bis(octyloxy)-)
• 75056-76-7(2,5-Dimethoxy-4-iodotoluene)
• 2314-37-6(3-Iodo-4-methoxybenzaldehyde)
• 70738-04-4(Benzaldehyde, 2-iodo-3,6-dimethoxy-)
• 121404-83-9(4-Iodo-3-methoxybenzaldehyde)