Production Method 1

38493-59-3

89978-72-3

Reaction Conditions

1.1 Reagents: Triphenylphosphine Solvents: Dichloromethane ;  10 min, rt
1.2 Reagents: Carbon tetrabromide ;  2 h, -78 °C

Reference

Total synthesis of acerogenins E, G and K, and centrolobol

Ogura, Tetsuhiro; Usuki, Toyonobu, Tetrahedron, 2013, 69(13), 2807-2815

Production Method 2

104-93-8

89978-72-3

22002-45-5

Reaction Conditions

1.1 Reagents: Sodium bromide ,  Hydrogen bromide Solvents: Chloroform ,  Water ;  10 - 25 °C

Reference

Nuclear versus side-chain bromination of 4-methoxy toluene by an electrochemical method

Kulangiappar, K.; Anbukulandainathan, M.; Raju, T., Synthetic Communications, 2014, 44(17), 2494-2502

Production Method 3

22002-45-5

89978-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide

Reference

Design, synthesis and biological evaluation as immunosuppressant of amino alcohol derivatives containing thioether

Li, Yanjie; Li, Yongqiang; Yang, Liu; Liu, Zhi; Zhang, Ruimeng; et al, Materials Express, 2021, 11(5), 773-780

Production Method 4

38493-59-3

89978-72-3

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Diethyl ether ;  rt → 4 °C; 30 min, 4 °C; 1.5 h, 4 °C; 4 °C → rt; 15 h, rt

Reference

Stereoselective synthesis of bromine- and fluorine-substituted (S)-tyrosines and N-BOC-protected derivatives

Sagiyan, A. S.; Babayan, E. P.; Geolchanyan, A. V.; Oganesyan, A. M.; Pripadchev, D. A.; et al, Hayastani Kimiakan Handes, 2007, 60(1), 61-72

Production Method 5

104-93-8

89978-72-3

Reaction Conditions

1.1 Reagents: Sodium bromide Catalysts: Hydrogen bromide Solvents: Chloroform ,  Water ;  15 °C

Reference

Electrochemical Method for the Preparation of Dibromomethyl, Bis(bromomethyl), and Bis(dibromomethyl) Arenes

Kulangiappar, K.; Karthik, G.; Kulandainathan, M. Anbu, Synthetic Communications, 2009, 39(13), 2304-2309

Production Method 6

22002-45-5

89978-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Carbon tetrachloride ;  4 h, reflux

Reference

Design, synthesis and biological evaluation of substituted aminopyridazin-3(2H)-ones as G0/G1-phase arresting agents with apoptosis-inducing activities

Ge, Bing-Chen; Feng, Hong-Fang; Cheng, Yu-Fang; Wang, Hai-Tao; Xi, Bao-Ming; et al, European Journal of Medicinal Chemistry, 2017, 141, 440-445

2-bromo-4-(bromomethyl)-1-methoxybenzene Raw materials

• 4-Methylanisole
• 3-Bromo-4-methoxy toluene
• 3-Bromo-4-methoxybenzyl Alcohol

2-bromo-4-(bromomethyl)-1-methoxybenzene Preparation Products

• 2-bromo-4-(bromomethyl)-1-methoxybenzene (89978-72-3)
• 3-Bromo-4-methoxy toluene (22002-45-5)

• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
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• 2. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
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• 3. Evolution and characterization of a benzylguanine-binding RNA aptamer?
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• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl halides Benzyl bromides

• 103260-55-5(2-Bromo-1-ethoxy-4-methylbenzene)
• 51699-89-9(2,6-Dibromo-4-methylanisole)
• 59297-29-9(3-Bromo-5-methoxybenzyl Bromide)
• 89722-16-7(Naphthalene, 1-bromo-5-(bromomethyl)-2-methoxy-)
• 948550-74-1(4-Bromo-3,5-dimethoxybenzyl Bromide)
• 95740-49-1(1-bromo-2-methoxy-4-methylbenzene)
• 34841-06-0(3-Bromo-4-methoxybenzaldehyde)
• 74447-73-7(3-Bromo-4-methoxybiphenyl)
• 22002-45-5(3-Bromo-4-methoxy toluene)
• 108989-36-2(3,3'-Dibromo-4,4'-dimethoxybiphenyl)