Production Method 1

87199-15-3

89951-79-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Palladium diacetate ,  1,1′,1′′,1′′′-[1,2,4,5-Benzenetetrayltetrakis(methylene)]tetrakis[4-piperidinol] Solvents: Ethanol ,  Water ;  1.5 h, rt

Reference

Development of Unimolecular Tetrakis(piperidin-4-ol) as a Ligand for Suzuki-Miyaura Cross-Coupling Reactions: Synthesis of Incrustoporin and Preclamol

Nallasivam, Jothi L.; Fernandes, Rodney A., European Journal of Organic Chemistry, 2015, 2015(16), 3558-3567

Production Method 2

624-31-7

87199-15-3

89951-79-1

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Palladium Solvents: Dimethylformamide ,  Water ;  30 min, 90 °C

Reference

Studies on Pd/NiFe2O4 catalyzed ligand-free Suzuki reaction in aqueous phase: synthesis of biaryls, terphenyls and polyaryls

Borhade, Sanjay R.; Waghmode, Suresh B., Beilstein Journal of Organic Chemistry, 2011, 7, 310-319

Production Method 3

873-63-2

216434-82-1

89951-79-1

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: Palladium diacetate ,  3-(Dicyclohexylphosphino)-1-methyl-2-phenyl-1H-indole Solvents: Dichloromethane ;  rt; 1 - 2 min, heated
1.2 Reagents: Cesium carbonate Solvents: Water ;  18 h, 100 °C

Reference

A general Suzuki-Miyaura coupling of aryl chlorides with potassium aryltrifluoroborates in water catalyzed by an efficient CPCy phendole-phos-palladium complex

Yuen, On Ying; Wong, Shun Man; Chan, Kin Fai; So, Chau Ming; Kwong, Fuk Yee, Synthesis, 2014, 46(20), 2826-2832

Production Method 4

116470-54-3

89951-79-1

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Ethanol ;  rt

Reference

Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469

Christiansen, Elisabeth; Due-Hansen, Maria E.; Urban, Christian; Merten, Nicole; Pfleiderer, Michael; et al, ACS Medicinal Chemistry Letters, 2010, 1(7), 345-349

Production Method 5

57455-06-8

126485-51-6

89951-79-1

Reaction Conditions

1.1 Reagents: Potassium fluoride Catalysts: Di-μ-chlorobis(η3-2-propenyl)dipalladium Solvents: Dimethylformamide

Reference

Highly selective cross-coupling reactions of aryl(halo)silanes with aryl halides: a general and practical route to functionalized biaryls

Hatanaka, Yasuo; Goda, Kenichi; Okahara, Yoshinori, Tetrahedron, 1994, 50(28), 8301-16

Production Method 6

57455-06-8

126485-51-6

89951-79-1

Reaction Conditions

1.1 Reagents: Potassium fluoride Catalysts: Di-μ-chlorobis(η3-2-propenyl)dipalladium Solvents: Dimethylformamide

Reference

Selective synthesis of unsymmetrical biaryls via palladium-catalyzed cross-coupling of arylfluorosilanes with aryl iodides

Hatanaka, Yasuo; Fukushima, Satoshi; Hiyama, Tamejiro, Chemistry Letters, 1989, (10), 1711-14

Production Method 7

3132-99-8

5720-05-8

89951-79-1

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Catalysts: Triphenylphosphine ,  2947562-92-5 Solvents: Isopropanol ,  Tetrahydrofuran ;  9 h, 90 °C
1.2 Reagents: Water ;  20 h, 84 °C

Reference

A naphthalene-based heterobimetallic triazolylidene IrIII/PdII complex: regioselective to regiospecific C-H activation, tandem catalysis and a copper-free Sonogashira reaction

Majumder, Adhir; Naskar, Rajat; Roy, Pallabi; Mondal, Bhaskar; Garai, Somenath; et al, Dalton Transactions, 2023, 52(8), 2272-2281

(4'-Methyl-1,1’-biphenyl-3-yl)methanol Raw materials

• 3-Chlorobenzyl alcohol
• 4-Iodotoluene
• 3-(Hydroxymethyl)phenylboronic acid
• Potassium p-tolyltrifluoroborate
• 3-Bromobenzaldehyde
• 3-Iodobenzyl alcohol
• 4'-Methylbiphenyl-3-carbaldehyde
• Silane, ethyldifluoro(4-methylphenyl)-
• 4-Methylbenzeneboronic Acid

(4'-Methyl-1,1’-biphenyl-3-yl)methanol Preparation Products

• (4'-Methyl-1,1’-biphenyl-3-yl)methanol (89951-79-1)

• 1. An investigation on the interaction modes of a single-strand DNA aptamer and RBP4 protein: a molecular dynamic simulations approach?
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• 198206-29-0((2'-Methyl-[1,1'-biphenyl]-4-yl)methanol)
• 158228-77-4([1,1':3',1''-Terphenyl]-4,4''-dimethanol(9CI))
• 773872-33-6((3'-Methylbiphenyl-4-yl)-methanol)
• 773872-41-6((3'-Methyl-1,1’-biphenyl-3-yl)methanol)
• 885963-84-8([1,1'-Biphenyl]-4-methanol,3',4'-dimethyl-)
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• 69605-90-9(1,1'-Biphenyl-3-ylmethanol)
• 76350-85-1((2'-Methoxy-1,1'-biphenyl-3-yl)methanol)
• 79757-92-9((4'-Methylbiphenyl-4-yl)-methanol)