• 1. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
• 2. An amplified fluorescence detection of T4 polynucleotide kinase activity based on coupled exonuclease III reaction and a graphene oxide platform?
  Ni-Na Sun,Fengli Qu,Xiaobing Zhang,Shufang Zhang,Jinmao You Analyst, 2015,140, 1827-1831
• 3. An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy
  Michael Kappl,Paul M. Young,Daniela Traini,Sanyog Jain RSC Adv., 2016,6, 25789-25798
• 4. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
  R. M. Pemberton,J. P. Hart,T. T. Mottram Analyst, 2001,126, 1866-1871
• 5. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Imidazoles Substituted imidazoles

1H-Imidazole-4,5-Dicarboxylic Acid, 2-Ethyl-, Diethyl Ester (CAS No: 89946-68-9)

The compound 1H-imidazole-4,5-dicarboxylic acid, 2-ethyl-, diethyl ester (CAS No: 89946-68-9) is a significant organic compound with a unique structure and diverse applications. This compound belongs to the imidazole family of heterocyclic compounds, which are widely studied in various fields due to their versatile properties. The imidazole ring serves as the core structure of this molecule, with two carboxylic acid groups attached at the 4 and 5 positions and an ethyl group at the 2 position. The diethyl ester functionality further enhances its chemical reactivity and solubility properties.

Recent studies have highlighted the potential of 1H-imidazole-4,5-dicarboxylic acid derivatives in drug design and material science. For instance, researchers have explored the use of this compound as a precursor for synthesizing bioactive molecules with anti-inflammatory and antioxidant properties. The diethyl ester groups in the molecule play a crucial role in modulating its pharmacokinetic profile, making it a promising candidate for drug delivery systems.

The synthesis of 1H-imidazole-4,5-dicarboxylic acid, 2-ethyl-, diethyl ester involves a multi-step process that typically includes nucleophilic substitution and esterification reactions. The choice of reagents and reaction conditions is critical to ensure high yields and purity. Recent advancements in catalytic methods have enabled more efficient synthesis pathways, reducing production costs and environmental impact.

In terms of physical properties, this compound exhibits a melting point of approximately 120°C and is soluble in common organic solvents such as dichloromethane and ethyl acetate. Its imidazole core contributes to its aromatic stability, while the ester groups enhance its hydrophobicity. These properties make it suitable for applications in polymer chemistry, where it can be used as a building block for constructing functional polymers with tailored mechanical and thermal properties.

One of the most exciting developments involving this compound is its role in the synthesis of advanced materials for energy storage applications. Researchers have demonstrated that derivatives of 1H-imidazole-4,5-dicarboxylic acid can be used as precursors for carbon-based materials with high surface area and conductivity. These materials show promise in improving the performance of supercapacitors and lithium-ion batteries.

Moreover, the diethyl ester functionality of this compound has been exploited in the development of novel coatings and adhesives. Its ability to form cross-linked networks upon exposure to UV light makes it ideal for use in photoresists and other advanced materials. Recent studies have also explored its application in biomedical engineering, where it has been used as a scaffold for tissue engineering due to its biocompatibility and degradability.

In conclusion, 1H-imidazole-4,5-dicarboxylic acid, 2-ethyl-, diethyl ester (CAS No: 89946-68-9) is a versatile compound with a wide range of applications across multiple disciplines. Its unique chemical structure and functional groups make it an invaluable tool in drug discovery, material science, and industrial chemistry. As research continues to uncover new potential uses for this compound, its significance in both academic and industrial settings is expected to grow further.

• 1093266-00-2(4-methyl-2-(1-methylethyl)-1H-Imidazole-5-carboxylic acid ethyl ester)
• 76100-28-2(1H-Imidazole-4,5-dicarboxylic acid, 2-butyl-, dimethyl ester)
• 1093266-08-0(2-cyclopropyl-4-methyl-1H-Imidazole-5-carboxylic acid ethyl ester)
• 146650-89-7(4-methyl-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester)
• 500890-03-9(ethyl 2,5-dimethyl-1H-imidazole-4-carboxylate)
• 65611-53-2(1H-Imidazole-4,5-dicarboxylic acid, 2-methyl-, diethyl ester)
• 144689-94-1(Diethyl-2-propylimidazole-4,5-dicarboxylate)
• 124750-59-0(2-Propyl-4,5-imidazoledicarboxylic acid dimethyl ester)
• 701292-63-9(1H-Imidazole-5-carboxylicacid, 2-ethyl-4-methyl-, methyl ester)
• 773138-27-5(1H-Imidazole-5-carboxylicacid, 2-ethyl-, ethyl ester)