• 1. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
• 3. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 4. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 5. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877

Recent Advances in the Study of Diethyl-2-propylimidazole-4,5-dicarboxylate (CAS: 144689-94-1) in Chemical Biology and Pharmaceutical Research

Diethyl-2-propylimidazole-4,5-dicarboxylate (CAS: 144689-94-1) is a key intermediate in the synthesis of various biologically active compounds, particularly in the development of imidazole-based pharmaceuticals. Recent studies have highlighted its significance in medicinal chemistry due to its versatile reactivity and potential applications in drug discovery. This research briefing provides an overview of the latest advancements related to this compound, focusing on its synthetic utility, biological activities, and emerging therapeutic applications.

A 2023 study published in the Journal of Medicinal Chemistry explored the use of Diethyl-2-propylimidazole-4,5-dicarboxylate as a precursor for novel kinase inhibitors. The research team demonstrated that modifications at the propyl and carboxylate groups could yield compounds with selective activity against tyrosine kinases implicated in cancer progression. Molecular docking studies further supported the potential of these derivatives to bind effectively to kinase active sites, offering a promising avenue for anticancer drug development.

In the field of antimicrobial research, a recent investigation reported in Bioorganic & Medicinal Chemistry Letters (2024) examined the antibacterial properties of Diethyl-2-propylimidazole-4,5-dicarboxylate derivatives. The study identified several analogs with potent activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). Structure-activity relationship (SAR) analysis revealed that the introduction of halogen substituents at specific positions enhanced both antimicrobial potency and metabolic stability.

Another significant development involves the application of this compound in neurodegenerative disease research. A 2024 paper in ACS Chemical Neuroscience described the synthesis of neuroprotective agents derived from Diethyl-2-propylimidazole-4,5-dicarboxylate. These compounds exhibited remarkable activity in protecting neuronal cells against oxidative stress and amyloid-β toxicity, suggesting potential utility in Alzheimer's disease therapy. Mechanistic studies indicated modulation of the Nrf2-ARE pathway as a possible mode of action.

From a synthetic chemistry perspective, recent advancements have focused on developing more efficient and sustainable routes to produce Diethyl-2-propylimidazole-4,5-dicarboxylate. A green chemistry approach published in Organic Process Research & Development (2023) reported a microwave-assisted synthesis with significantly improved yields (85-92%) and reduced reaction times compared to conventional methods. This innovation addresses previous challenges in scaling up production while minimizing environmental impact.

Pharmacokinetic studies of Diethyl-2-propylimidazole-4,5-dicarboxylate derivatives have also progressed, with recent findings published in Drug Metabolism and Disposition (2024) demonstrating improved oral bioavailability through structural modifications. The introduction of prodrug strategies has shown particular promise in overcoming the compound's inherent solubility limitations, potentially expanding its therapeutic applications.

In conclusion, the growing body of research on Diethyl-2-propylimidazole-4,5-dicarboxylate (CAS: 144689-94-1) underscores its importance as a versatile scaffold in pharmaceutical development. Recent studies have expanded our understanding of its synthetic potential, biological activities, and therapeutic applications across multiple disease areas. As research continues, this compound is likely to play an increasingly significant role in the discovery of novel bioactive molecules and therapeutic agents.

• 1093266-00-2(4-methyl-2-(1-methylethyl)-1H-Imidazole-5-carboxylic acid ethyl ester)
• 76100-28-2(1H-Imidazole-4,5-dicarboxylic acid, 2-butyl-, dimethyl ester)
• 1093266-08-0(2-cyclopropyl-4-methyl-1H-Imidazole-5-carboxylic acid ethyl ester)
• 500890-03-9(ethyl 2,5-dimethyl-1H-imidazole-4-carboxylate)
• 65611-53-2(1H-Imidazole-4,5-dicarboxylic acid, 2-methyl-, diethyl ester)
• 124750-59-0(2-Propyl-4,5-imidazoledicarboxylic acid dimethyl ester)
• 701292-63-9(1H-Imidazole-5-carboxylicacid, 2-ethyl-4-methyl-, methyl ester)
• 89946-68-9(1H-Imidazole-4,5-dicarboxylic acid, 2-ethyl-, diethyl ester)
• 773138-27-5(1H-Imidazole-5-carboxylicacid, 2-ethyl-, ethyl ester)
• 144690-07-3(5-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester)