Production Method 1

57319-65-0

89877-62-3

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water ;  0 °C
1.2 Reagents: Cuprous cyanide Solvents: Water ;  0 °C; 0 °C → rt; 3.5 h, rt

Reference

Discovery of Potent Indenoisoquinoline Topoisomerase I Poisons Lacking the 3-Nitro Toxicophore

Beck, Daniel E.; Abdelmalak, Monica; Lv, Wei; Reddy, P. V. Narasimha; Tender, Gabrielle S.; et al, Journal of Medicinal Chemistry, 2015, 58(9), 3997-4015

Production Method 2

1975-54-8

89877-62-3

Reaction Conditions

1.1 Reagents: Tetrabutylammonium bromide ,  Sodium persulfate Solvents: Acetonitrile ;  18 h, 80 °C

Reference

Peroxydisulfate-Mediated Transition-Metal-Free Oxidative C(sp3)-H Bond Lactonization

Nozawa-Kumada, Kanako; Kurosu, Satoshi; Shigeno, Masanori ; Kondo, Yoshinori, Asian Journal of Organic Chemistry, 2019, 8(7), 1080-1083

Production Method 3

1446757-51-2

89877-62-3

82104-74-3

Reaction Conditions

1.1 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Catalysts: 2-Iodo-3,4,5,6-tetramethylbenzoic acid Solvents: Acetonitrile ,  Water ;  8 h, 30 °C

Reference

Facile organocatalytic domino oxidation of diols to lactones by in situ-generated TetMe-IBX

Jhulki, Samik; Seth, Saona; Mondal, Manas; Moorthy, Jarugu Narasimha, Tetrahedron, 2014, 70(13), 2286-2293

6-Cyanophthalide Raw materials

• 6-amino-1,3-dihydro-2-benzofuran-1-one
• 5-Cyano-2-methylbenzoic acid
• Benzonitrile, 3,4-bis(hydroxymethyl)-

6-Cyanophthalide Preparation Products

• 5-Cyanophthalide (82104-74-3)
• 6-Cyanophthalide (89877-62-3)

• 1. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 2. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 5. An approach to the structure and vibrational analysis of cis- and trans-3-chlorostyrene through IR/Raman and INS spectroscopies and theoretical ab initio/DFT calculations?
  J. M. Granadino-Roldán,M. Fernández-Gómez,A. Navarro,T. Pe?a Ruiz,U. A. Jayasooriya Phys. Chem. Chem. Phys., 2004,6, 1133-1143

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isocoumarans Phthalides
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isocoumarans Isobenzofuranones Phthalides

• 82104-74-3(5-Cyanophthalide)
• 220389-17-3(Ethyl 4-cyano-2-methylbenzoate)
• 1261852-00-9(ethyl 2-cyano-3-methylbenzoate)
• 65975-31-7(5,6-Isobenzofurandicarbonitrile, 1,3-dihydro-1-oxo-)
• 374905-57-4(5-Isobenzofurancarbonitrile, 1,3-dihydro-4,6-dimethyl-3-oxo-)
• 90483-95-7(1-oxo-1,3-dihydroisobenzofuran-4-carbonitrile)
• 53935-68-5(5,6,7-Trimethyl-1-oxo-1,3-dihydro-2-benzofuran-4-carbonitrile)
• 53935-69-6(4,6,7-Trimethyl-1-oxo-1,3-dihydro-2-benzofuran-5-carbonitrile)
• 374905-59-6(4-Isobenzofurancarbonitrile, 1,3-dihydro-5,7-dimethyl-1-oxo-)
• 6525-45-7(Ethyl 2-cyanobenzoate)