Production Method 1

61-90-5

89836-93-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydrogen ,  Water-d2 Catalysts: Ruthenium ;  72 h, 70 °C; 70 °C → rt
1.2 Reagents: Dowex 50W-X8 ;  pH 5 - 6, rt

Reference

Development and Scale-Up of Stereoretentive α-Deuteration of Amines

Michelotti, Alessia; Rodrigues, Fabien; Roche, Maxime, Organic Process Research & Development, 2017, 21(11), 1741-1744

Production Method 2

61-90-5

89836-93-1

Reaction Conditions

1.1 Reagents: Water-d2 Catalysts: 3,5-Dichlorosalicylaldehyde ,  (4S,5S)-4,5-Dihydro-4,5-di-2-naphthalenyl-1H-imidazol-2-amine Solvents: Chloroform-d ;  23 h, rt

Reference

Catalytic stereoinversion of L-alanine to deuterated D-alanine

Moozeh, Kimia; So, Soon Mog; Chin, Jik, Angewandte Chemie, 2015, 54(32), 9381-9385

Production Method 3

2411258-77-8

89836-93-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  30 min, 80 °C

Reference

Synthesis of enantioenriched α-deuterated α-amino acids enabled by an organophotocatalytic radical approach

Ji, Peng; Zhang, Yueteng; Dong, Yue; Huang, He; Wei, Yongyi; et al, Organic Letters, 2020, 22(4), 1557-1562

Production Method 4

61-90-5

89836-93-1

Reaction Conditions

1.1 Reagents: Deuterium Catalysts: Ruthenium Solvents: Water-d2 ;  36 h, 2 bar, 55 °C

Reference

Enantiospecific C-H activation using ruthenium nanocatalysts

Taglang, Celine; Martinez-Prieto, Luis Miguel; del Rosal, Iker; Maron, Laurent; Poteau, Romuald; et al, Angewandte Chemie, 2015, 54(36), 10474-10477

Production Method 5

61-90-5

89836-93-1

Reaction Conditions

1.1 Reagents: Water-d2 ,  Tryptophanase

Reference

Preparation of α-deuterated L-amino acids by E. coli cells containing tryptophanase

Faleev, N. G.; Ruvinov, S. B.; Saporovskaya, M. B.; Belikov, V. M.; Zakomyrdina, L. N.; et al, Izvestiya Akademii Nauk SSSR, 1989, (10), 2341-3

L-Leucine-2-d1 Raw materials

• Phenylmethyl (2S,4S)-2-(1,1-dimethylethyl)-4-(2-methylpropyl)-5-oxo-3-oxazolidine-4-d-carboxylate
• L-Leucine

L-Leucine-2-d1 Preparation Products

• L-Leucine-2-d1 (89836-93-1)

• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 3. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 4. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 5. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

• 328-39-2((±)-Leucine)
• 72-18-4(L-Valine)
• 328-38-1((2R)-2-amino-4-methylpentanoic acid)
• 70-54-2(DL-Lysine)
• 443-79-8(DL-Isoleucine)
• 327-57-1(L-Norleucine)
• 56-86-0(L-Glutamic acid)
• 61-90-5(L-Leucine)
• 327-56-0(D-(-)-Norleucine)
• 56-87-1(L-Lysine)