Production Method 1

89794-02-5

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Boron trifluoride etherate ,  Gold trichloride Solvents: 1,2-Dichloroethane ;  11 h, 60 °C

Reference

Gold-catalyzed halogenation of aromatics by N-halosuccinimides

Mo, Fanyang; Yan, Jerry Mingtao; Qiu, Di; Li, Fei; Zhang, Yan; et al, Angewandte Chemie, 2010, 49(11), 2028-2032

Production Method 2

39478-78-9

89794-02-5

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  1.5 h, 80 °C; 80 °C → 40 °C
1.2 Reagents: Cuprous chloride ;  30 min, 40 °C
1.3 Reagents: Sodium nitrite Solvents: Water ;  30 min, 40 °C; 40 °C → 60 °C; 2.5 h, 60 °C

Reference

Synthesis of 4-bromo-2-chlorotoluene

Xue, Xuming; Zhao, Haoyu; Jiang, Tao, Zhongguo Yiyao Gongye Zazhi, 2006, 37(9), 588-589

Production Method 3

89794-02-5

Reaction Conditions

1.1 Reagents: Bromine

Reference

Qualitative studies on chromatographic peaks of monobromination products of o-chlorotoluene

Zhang, Lin, Hunan Shifan Daxue Ziran Kexue Xuebao, 1987, 10(1), 57-61

Production Method 4

89794-02-5

54932-72-8

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: 2-Propenoic acid, 2-methyl-, 3-(trimethoxysilyl)propyl ester, polymer with 1-eth… (on silica-supported iron oxide magnetic nanoparticles, gold chloride complex) Solvents: 1,2-Dichloroethane ;  15 h, 60 °C

Reference

A new recoverable Au(III) catalyst supported on magnetic polymer nanocomposite for aromatic bromination

Li, Bai; Gao, Linfeng; Bian, Fengling; Yu, Wei, Tetrahedron Letters, 2013, 54(9), 1063-1066

4-Bromo-2-chloro-1-methylbenzene Raw materials

• 5-Bromo-2-methylaniline

4-Bromo-2-chloro-1-methylbenzene Preparation Products

• 4-Bromo-2-chloro-1-methylbenzene (89794-02-5)
• 5-Bromo-2-chlorotoluene (54932-72-8)

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  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Chlorobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Chlorobenzenes
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 115615-19-5(2-Bromo-4,6-dichlorotoluene)
• 89720-77-4(4-Bromo-1-(bromomethyl)-2-chlorobenzene)
• 204930-37-0(5-Bromo-1,3-dichloro-2-methylbenzene)
• 933585-12-7(1-Bromo-2-chloro-3,5-dimethylbenzene)
• 62356-27-8(2-Bromo-6-chlorotoluene)
• 206559-40-2(5-Bromo-2-chloro-m-xylene)
• 329944-72-1(3-Bromo-5-chlorotoluene)
• 54932-72-8(5-Bromo-2-chlorotoluene)
• 185315-49-5(4-Bromo-2-chloro-1-(chloromethyl)benzene)
• 97329-43-6(3-Bromo-2-chlorotoluene)