Production Method 1

627525-96-6

1165936-01-5

89694-47-3

175883-60-0

Reaction Conditions

1.1 Reagents: Sodium periodate Solvents: Tetrahydrofuran ,  Water ;  30 min, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  17 h, rt

Reference

Regioselective Synthesis of o-Benzenediboronic Acids via Ir-Catalyzed o-C-H Borylation Directed by a Pyrazolylaniline-Modified Boronyl Group

Yamamoto, Takeshi; Ishibashi, Aoi; Suginome, Michinori, Organic Letters, 2017, 19(4), 886-889

(4-Chloro-3-methoxyphenyl)boronic acid Raw materials

• 2-(4-Chloro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• 2-(3-Chloro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

(4-Chloro-3-methoxyphenyl)boronic acid Preparation Products

• (3-chloro-4-methoxyphenyl)boronic acid (175883-60-0)
• (4-Chloro-3-methoxyphenyl)boronic acid (89694-47-3)

• 1. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 2. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
• 3. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115
• 4. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 5. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099

• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

(4-Chloro-3-Methoxyphenyl)Boronic Acid: A Comprehensive Overview

The compound (4-Chloro-3-Methoxyphenyl)Boronic Acid (CAS No. 89694-47-3) is a significant intermediate in organic synthesis, particularly in the field of medicinal chemistry and materials science. This boronic acid derivative has garnered attention due to its versatility in cross-coupling reactions, such as the Suzuki-Miyaura coupling, which is widely used to construct biaryl structures with high efficiency and precision.

Recent advancements in the synthesis of (4-Chloro-3-Methoxyphenyl)Boronic Acid have focused on improving the reaction conditions and scalability. Researchers have explored various catalysts and solvent systems to enhance the yield and purity of this compound, making it more accessible for large-scale applications. For instance, studies have demonstrated that the use of microwave-assisted synthesis can significantly reduce reaction times while maintaining high product quality.

The structural features of (4-Chloro-3-Methoxyphenyl)Boronic Acid make it an ideal candidate for the construction of complex aromatic systems. The presence of both a chlorine atom and a methoxy group on the aromatic ring introduces unique electronic properties, enabling selective reactivity in various coupling reactions. This dual functionality has been exploited in the development of novel pharmaceutical agents, where precise control over the chemical structure is critical.

In terms of applications, (4-Chloro-3-Methoxyphenyl)Boronic Acid has been extensively used in the synthesis of heterocyclic compounds, which are pivotal in drug discovery. Recent studies have highlighted its role in creating bioactive molecules with potential anti-cancer and anti-inflammatory properties. For example, a research group successfully synthesized a series of boron-containing heterocycles using this boronic acid as a key intermediate, demonstrating its utility in medicinal chemistry.

Moreover, the integration of (4-Chloro-3-Methoxyphenyl)Boronic Acid into polymer science has opened new avenues for material innovation. By incorporating this compound into polymeric frameworks, researchers have developed advanced materials with tailored electronic and mechanical properties. These materials hold promise for applications in electronics, sensors, and energy storage devices.

Looking ahead, the continued exploration of (4-Chloro-3-Methoxyphenyl)Boronic Acid is expected to drive further advancements in both academic research and industrial applications. Its role as a versatile building block in organic synthesis underscores its importance in modern chemistry, making it a subject of ongoing investigation and innovation.

• 279261-81-3((3-chloro-4-ethoxyphenyl)boronic acid)
• 915201-07-9((3-chloro-5-methoxyphenyl)boronic acid)
• 1256355-00-6((4-Chloro-3-(2-methoxyethoxy)phenyl)boronic acid)
• 175883-61-1((3,5-dichloro-4-methoxyphenyl)boronic acid)
• 854778-30-6((2-Chloro-3-methoxyphenyl)boronic acid)
• 175883-60-0((3-chloro-4-methoxyphenyl)boronic acid)
• 900174-62-1((4-Chloro-3-ethoxyphenyl)boronic acid)
• 179898-50-1((3-Chloro-2-methoxyphenyl)boronic acid)
• 681292-77-3(4-Chloro-3-propoxyphenylboronic acid)
• 431942-67-5(2,4-Dichloro-5-methoxyphenylboronic acid)