- Design, synthesis and in vitro activity of quinazolone glycine transporter-1 inhibitorsJiang, Neng; Jiang, Jian-qin; Shen, Jian-hua, Zhongguo Yaoke Daxue Xuebao, 2012, 43(3), 199-203
Cas no 895132-31-7 (1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine)
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine is a versatile intermediate in organic synthesis, particularly valuable for the preparation of pharmacologically active compounds. The Boc (tert-butoxycarbonyl) group provides excellent protection for the piperidine nitrogen, enabling selective functionalization under mild conditions. The cyano and cyclopropylmethyl substituents at the 4-position enhance its utility in constructing complex heterocyclic frameworks, often found in drug discovery. This compound exhibits high stability and compatibility with a range of reaction conditions, making it a reliable building block for medicinal chemistry applications. Its well-defined structure and purity ensure consistent performance in multi-step synthetic routes, particularly in the development of CNS-targeting and antiviral agents.
895132-31-7 structure
Product Name:1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine
CAS No:895132-31-7
MF:C15H24N2O2
MW:264.363264083862
MDL:MFCD11849800
CID:1942321
Update Time:2025-06-23
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine Chemical and Physical Properties
Names and Identifiers
-
- 1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine
- 1,1-Dimethylethyl 4-cyano-4-(cyclopropylmethyl)-1-piperidinecarboxylate (ACI)
- tert-Butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate
-
- MDL： MFCD11849800
- Inchi： 1S/C15H24N2O2/c1-14(2,3)19-13(18)17-8-6-15(11-16,7-9-17)10-12-4-5-12/h12H,4-10H2,1-3H3
- InChI Key： ILNVEWHRASLBNI-UHFFFAOYSA-N
- SMILES： N#CC1(CCN(C(OC(C)(C)C)=O)CC1)CC1CC1
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| CHENG DOU FEI BO YI YAO Technology Co., Ltd. | FC12943-5g |
tert-butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate |
895132-31-7 | 95% | 5g |
$1275 | 2023-09-07 | |
| Chemenu | CM131507-1g |
tert-butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate |
895132-31-7 | 95+% | 1g |
$309 | 2021-08-05 | |
| Chemenu | CM131507-5g |
tert-butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate |
895132-31-7 | 95+% | 5g |
$926 | 2021-08-05 | |
| Chemenu | CM131507-1g |
tert-butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate |
895132-31-7 | 95%+ | 1g |
$365 | 2023-03-07 | |
| Apollo Scientific | OR451121-1g |
1-Boc-4-cyano-4-(cyclopropylmethyl)-piperidine |
895132-31-7 | 1g |
￡900.00 | 2023-09-02 | ||
| Advanced ChemBlocks | P35316-250MG |
1-Boc-4-cyano-4-(cyclopropylmethyl)-piperidine |
895132-31-7 | 95% | 250MG |
$190 | 2023-09-15 | |
| Advanced ChemBlocks | P35316-1G |
1-Boc-4-cyano-4-(cyclopropylmethyl)-piperidine |
895132-31-7 | 95% | 1G |
$480 | 2023-09-15 | |
| Advanced ChemBlocks | P35316-5G |
1-Boc-4-cyano-4-(cyclopropylmethyl)-piperidine |
895132-31-7 | 95% | 5G |
$1,630 | 2023-09-15 | |
| 1PlusChem | 1P00H4UV-250mg |
1-BOC-4-CYANO-4-(CYCLOPROPYLMETHYL)-PIPERIDINE |
895132-31-7 | 97% | 250mg |
$143.00 | 2024-04-20 | |
| 1PlusChem | 1P00H4UV-500mg |
1-BOC-4-CYANO-4-(CYCLOPROPYLMETHYL)-PIPERIDINE |
895132-31-7 | 97% | 500mg |
$216.00 | 2024-04-20 |
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Potassium bis(trimethylsilyl)amide Solvents: Tetrahydrofuran ; cooled; 40 °C; 2 h, 40 °C
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Lithium bis(trimethylsilyl)amide Solvents: Tetrahydrofuran ; 25 °C
1.2 -
1.2 -
Reference
- Discovery of GlyT1 inhibitors with improved pharmacokinetic propertiesWolkenberg, Scott E.; Zhao, Zhijian; Wisnoski, David D.; Leister, William H.; O'Brien, Julie; et al, Bioorganic & Medicinal Chemistry Letters, 2009, 19(5), 1492-1495
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine Raw materials
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine Preparation Products
1-Boc-4-Cyano-4-(Cyclopropylmethyl)-Piperidine Related Literature
-
Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
-
Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
-
Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
-
Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
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