Production Method 1

21279-64-1

89323-09-1

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Methanol ,  Water ;  30 min, 95 °C

Reference

Alkylamino derivatives of pyrazinamide: Synthesis and antimycobacterial evaluation

Servusova, Barbora; Paterova, Pavla; Mandikova, Jana; Kubicek, Vladimir; Kucera, Radim; et al, Bioorganic & Medicinal Chemistry Letters, 2014, 24(2), 450-453

Production Method 2

113305-94-5

89323-09-1

Reaction Conditions

1.1 Catalysts: Manganese oxide (MnO2) ,  Ruthenium Solvents: Water ;  3 h, 60 °C

Reference

An efficient hydration of nitriles with ruthenium-supported heterogeneous catalyst in water under moderate conditions

Hussain, Muhammad Asif; Choi, Eun Ju; Maqbool, Adnan ; Atif, Muhammad; Zeb, Hassan ; et al, Journal of Industrial and Engineering Chemistry (Amsterdam, 2021, 99, 187-195

Production Method 3

59489-71-3

89323-09-1

40155-43-9

Reaction Conditions

1.1 Reagents: Cuprous cyanide Solvents: Ethanol ,  Water
1.2 Reagents: Hydrochloric acid Solvents: Water
1.3 Reagents: Hydrogen sulfide
1.4 Reagents: Sodium hydroxide Solvents: Water
1.5 Reagents: Hydrochloric acid Solvents: Water

Reference

Pyrazine chemistry. IV. Bromination of 2-amino-3-carbomethoxypyrazine

Ellingson, R. C.; Henry, R. L., Journal of the American Chemical Society, 1949, 71, 2798-800

5-Aminopyrazine-2-carboxamide Raw materials

• 5-Chloropyrazine-2-carboxamide
• 5-bromopyrazin-2-amine
• 5-aminopyrazine-2-carbonitrile

5-Aminopyrazine-2-carboxamide Preparation Products

• 5-Aminopyrazine-2-carboxylic acid (40155-43-9)
• 5-Aminopyrazine-2-carboxamide (89323-09-1)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrazines Pyrazine carboxylic acids and derivatives

• 32587-10-3(3-Aminopyrazine-2-carboxamide)
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• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)