Production Method 1

891785-28-7

891785-30-1

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Pyridine, hydrofluoride (1:1) Solvents: Water ;  0 °C; > 0 °C; 1.5 h, 0 °C → rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

Kaniskan, H. Umit; Eram, Mohammad S.; Zhao, Kehao; Szewczyk, Magdalena M.; Yang, Xiaobao; et al, Journal of Medicinal Chemistry, 2018, 61(3), 1204-1217

Production Method 2

891785-28-7

891785-30-1

Reaction Conditions

1.1 Reagents: Sodium nitrite
1.2 Reagents: Hydrofluoric acid Solvents: Pyridine

Reference

Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity

Zhu, Gui-Dong; Gong, Jianchun; Claiborne, Akiyo; Woods, Keith W.; Gandhi, Viraj B.; et al, Bioorganic & Medicinal Chemistry Letters, 2006, 16(12), 3150-3155

6-Bromo-3-fluoroisoquinoline Raw materials

• 6-bromoisoquinolin-3-amine

6-Bromo-3-fluoroisoquinoline Preparation Products

• 6-Bromo-3-fluoroisoquinoline (891785-30-1)

• 1. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 2. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
• 3. Aggregation-induced emission based on a fluorinated macrocycle: visualizing spontaneous and ultrafast solid-state molecular motions at room temperature via F?F interactions?
  Mei Zhang,Jingjing Guo,Tingting Liu,Zhanyu He,Majeed Irfan,Zujin Zhao,Zhuo Zeng J. Mater. Chem. C, 2020,8, 14919-14924
• 4. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 5. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804

• 36178-05-9(3-Bromo-2-fluoropyridine)
• 128071-98-7(4-Bromo-2-fluoropyridine)
• 1177269-74-7(4-bromo-2-fluoro-Pyridine hydrochloride)
• 40247-45-8(4-BROMO-2-FLUOROPYRIDINE)
• 179488-06-3(3-bromo-2-fluoroquinoline)
• 8038-90-2(3-Bromo-2,6-difluoropyridine)
• 396-29-2(3-Fluoroisoquinoline)
• 766-11-0(5-Bromo-2-fluoropyridine)
• 903513-58-6(2,6-difluoro-4-bromopyridine)
• 80392-79-6(3-Bromo-2,6-difluoropyridine)