Production Method 1

81329-32-0

890652-03-6

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ;  12 h, reflux

Reference

New pyrazole derivative 5-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole: Synthesis and assessment of some biological activities

Porfiro de Oliveira, Lanussy; Bueno da Silva, Daiany Priscilla; Florentino, Iziara Ferreira; Fajemiroye, James Oluwagbamigbe; Sardinha de Oliveira, Thiago; et al, Chemical Biology & Drug Design, 2017, 89(1), 124-135

Production Method 2

35344-95-7

890652-03-6

936940-82-8

1015845-52-9

Reaction Conditions

1.1 Reagents: Acetic acid ,  Lithium perchlorate Catalysts: Cyclopropenylium, 1,2,3-tris[(2R,6S)-2,6-dimethyl-1-piperidinyl]-, rel-, perchlo… Solvents: Acetonitrile ;  60 h, rt

Reference

Electrophotocatalysis with a trisaminocyclopropenium radical dication

Huang, He; Strater, Zack M.; Rauch, Michael; Shee, James; Sisto, Thomas J.; et al, Angewandte Chemie, 2019, 58(38), 13318-13322

Production Method 3

81329-32-0

890652-03-6

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ;  12 h, reflux
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized

Reference

Chemoselective and regiospecific formylation of 1-phenyl-1H-pyrazoles through the Duff reaction

de Oliveira, C. H. A.; Mairink, L. M.; Pazini, F.; Liao, L. M.; de Oliveira, A. L.; et al, Synthetic Communications, 2013, 43(12), 1633-1639

Production Method 4

35344-95-7

890652-03-6

Reaction Conditions

1.1 Reagents: Acetic acid ,  Tetrabutylammonium tetrafluoroborate Catalysts: 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone Solvents: Acetonitrile ;  36 h, rt

Reference

Electrophotocatalytic SNAr Reactions of Unactivated Aryl Fluorides at Ambient Temperature and Without Base

Huang, He; Lambert, Tristan H., Angewandte Chemie, 2020, 59(2), 658-662

Production Method 5

81329-32-0

890652-03-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide ;  -5 °C; 1 h, -5 °C; -5 °C → 80 °C
1.2 80 °C; 5 h, 80 °C
1.3 Reagents: Water ;  overnight, cooled
1.4 Reagents: Sodium bicarbonate Solvents: Water ;  pH 5 - 6

Reference

Synthesis and characterization of novel arylformoylpyrazole

Liu, Shu-yun; Ren, Tie-gang; Chen, Hong-bin; Li, Gui-hui, Henan Daxue Xuebao, 2012, 42(2), 154-158

Production Method 6

35344-95-7

890652-03-6

Reaction Conditions

1.1 Catalysts: Antimony pentachloride ,  1820760-34-6 Solvents: Acetonitrile ;  16 h

Reference

Oxidative con-PET catalysis for arene functionalization

Bieszczad, Bartosz; Karl, Tobias A.; Rolka, Alessa B.; Nuernberger, Patrick; Kutta, Roger J.; et al, ChemRxiv, 2022, 1, 1-49

1-(4-Fluorophenyl)-1H-pyrazole-4-carbaldehyde Raw materials

• 1H-Pyrazole-4-carbaldehyde
• 1-(4-Fluorophenyl)pyrazole

1-(4-Fluorophenyl)-1H-pyrazole-4-carbaldehyde Preparation Products

• 1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde (936940-82-8)
• 1-(4-Fluorophenyl)-1H-pyrazole-4-carbaldehyde (890652-03-6)
• 1-(2-Fluorophenyl)-1H-pyrazole-4-carbaldehyde (1015845-52-9)

• 1. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 2. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 3. An autoreduction method to prepare plasmonic gold-embedded polypeptide micelles for synergistic chemo-photothermal therapy?
  Xingjie Wu,Linzhu Zhou,Yue Su,Chang-Ming Dong J. Mater. Chem. B, 2016,4, 2142-2152
• 4. Achieving molecular stability of racemic 4-O-benzyl-myo-inositol-1,3,5-orthoformate through crystal formation?
  Richa Sardessai,Shobhana Krishnaswamy,Mysore S. Shashidhar CrystEngComm, 2012,14, 8010-8016
• 5. An ionic liquid-based synergistic extraction strategy for rare earths?
  Yingbo Li,Nada Mehio,Huizhou Liu,Sheng Dai Green Chem., 2015,17, 2981-2993

• 936940-82-8(1-(3-Fluorophenyl)-1H-pyrazole-4-carbaldehyde)
• 153863-34-4(1-(4-fluorophenyl)-1H-pyrazol-4-ylmethanol)
• 3968-40-9(4-Acetyl-1-phenyl-1H-pyrazole)
• 1134310-63-6(1-(2-Fluorophenyl)-1H-pyrazole-4-carboxylic acid)
• 337957-59-2(1-(4-methylphenyl)-1H-pyrazole-4-carbaldehyde)
• 433920-86-6(4-(4-Methyl-1H-pyrazol-1-yl)benzaldehyde)
• 54605-72-0(1-Phenyl-1H-pyrazole-4-carbaldehyde)
• 138907-82-1(1-(3-fluorophenyl)-1H-pyrazole-4-carboxylic acid)
• 138907-81-0(1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid)
• 1015845-52-9(1-(2-Fluorophenyl)-1H-pyrazole-4-carbaldehyde)