Production Method 1

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Imidazole Solvents: Dichloromethane ;  1 h, rt

Reference

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections

Tasdemir, Deniz; Sanabria, David; Lauinger, Ina L.; Tarun, Alice; Herman, Rob; et al, Bioorganic & Medicinal Chemistry, 2010, 18(21), 7475-7485

Production Method 2

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Imidazole Solvents: Dichloromethane ;  3 h, rt
1.2 Reagents: Ammonium chloride Solvents: Ethyl acetate ,  Water ;  rt

Reference

Racemic total synthesis of dactyloidin and demethyldactyloidin through the DL-proline-catalyzed Knoevenagel condensation/[4 + 2] cycloaddition cascade

Tan, Haibo; Liu, Hongxin; Chen, Xinzheng; Chen, Huiyu; Qiu, Shengxiang, Organic & Biomolecular Chemistry, 2015, 13(39), 9977-9983

Production Method 3

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Imidazole Solvents: Dichloromethane

Reference

Nitric oxide-responsive vesicles as a drug delivery system

Li, Zhi-Heng; Tan, Zheng-Li; Ding, Ai-Xiang; Gong, Bing; Lu, Zhong-Lin; et al, Chemical Communications (Cambridge, 2017, 53(25), 3535-3538

Production Method 4

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Imidazole Solvents: Tetrahydrofuran ;  10 min, rt
1.2 rt; 2 h, rt

Reference

Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus

Jana, Santanu ; Sarpe, Vikram A.; Kulkarni, Suvarn S., Organic Letters, 2018, 20(21), 6938-6942

Production Method 5

87184-99-4

89043-32-3

Reaction Conditions

1.1 Reagents: Tetrabutylammonium bromide ,  Methanaminium, chlorodimethyl(phenylthio)-, chloride (1:1) Solvents: Dichloromethane

Reference

[Chloro(phenylthio)methylene]dimethylammonium chloride (CPMA), an efficient reagent for selective chlorination and bromination of primary alcohols

Gomez, L.; Gellibert, F.; Wagner, A.; Mioskowski, C., Tetrahedron Letters, 2000, 41(32), 6049-6052

Production Method 6

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Imidazole Solvents: Dimethylformamide ;  0 °C; 0 °C → 25 °C; 2 h, 25 °C

Reference

Mass Spectrometric Characterization of Protein Modification by the Products of Nonenzymatic Oxidation of Linoleic Acid

Zhu, Xiaochun; Tang, Xiaoxi a; Anderson, Vernon E.; Sayre, Lawrence M., Chemical Research in Toxicology, 2009, 22(8), 1386-1397

Production Method 7

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Imidazole Solvents: Dichloromethane ;  12 h, rt

Reference

Stereoselective construction of sterically hindered oxaspirocycles via chiral bidentate directing group-mediated C(sp3)-O bond formation

Kim, Yechan; Kim, Seoung-Tae; Kang, Dahye; Sohn, Te-ik; Jang, Eunyoung; et al, Chemical Science, 2018, 9(6), 1473-1480

Production Method 8

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Imidazole Solvents: Dimethylformamide

Reference

Synthetic studies towards clerodane diterpenes

Whittle, Alan John, 1981, , ,

Production Method 9

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Imidazole Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  2 h, 0 °C; 0 °C → 25 °C; 12 h, 25 °C
1.2 Reagents: Ammonium chloride Solvents: Water ;  25 °C

Reference

Synthesis of 2-Azabicyclo[m.n.0]-Alkanes and Their Application towards the Synthesis of Strychnos and Stemona Classes of Alkaloids

Majumder, Binoy; Pandey, Ganesh, European Journal of Organic Chemistry, 2020, 2020(25), 3883-3888

Production Method 10

18162-48-6

9016-18-6

89043-32-3

Reaction Conditions

1.1 Reagents: Triethylamine ,  4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  overnight, rt

Reference

Structure Assignment, Total Synthesis, and Antiviral Evaluation of Cycloviracin B1

Fuerstner, Alois; Albert, Martin; Mlynarski, Jacek; Matheu, Maribel; DeClercq, Erik, Journal of the American Chemical Society, 2003, 125(43), 13132-13142

Production Method 11

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane

Reference

Total Synthesis of the Antiviral Glycolipid Cycloviracin B1

Fuerstner, Alois; Mlynarski, Jacek; Albert, Martin, Journal of the American Chemical Society, 2002, 124(35), 10274-10275

Production Method 12

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Imidazole Solvents: Dichloromethane

Reference

Free radical cyclizations onto -C=N-R acceptors: kinetics and synthetic applications and synthesis of taxoid mimics

Tauh, Poonam, 2000, , 62(2),

Production Method 13

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Imidazole Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  overnight, 0 °C; 0 °C → 21 °C
1.2 Reagents: Ammonium chloride Solvents: Water ;  21 °C

Reference

Rate Constants for 5-Exo Secondary Alkyl Radical Cyclizations onto Hydrazones and Oxime Ethers via Intramolecular Competition Experiments

Tauh, Poonam; Fallis, Alex G., Journal of Organic Chemistry, 1999, 64(19), 6960-6968

Production Method 14

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Triethylamine ,  Diisopropylethylamine Solvents: Chloroform ;  10 h, rt

Reference

Design, Synthesis and Evaluation of Fe-S Targeted Adenosine 5'-Phosphosulfate Reductase Inhibitors

Paritala, Hanumantharao; Suzuki, Yuta; Carroll, Kate S., Nucleosides, 2015, 34(3), 199-220

Production Method 15

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  72 h, rt

Reference

Steroids modified at C15. Synthesis and spectra-structure correlations

Baranovskii, A. V.; Khripach, V. A., Russian Journal of General Chemistry, 2011, 81(10), 2142-2150

Production Method 16

98602-83-6

89043-32-3

Reaction Conditions

1.1 Reagents: Lithium bromide Solvents: Tetrahydrofuran ;  overnight, reflux

Reference

Isomerization reactions of allylic alcohols to ketones with the Grubbs reagent

Nakashima, Katsuyuki; Okamoto, Sanae; Sono, Masakazu; Tori, Motoo, Molecules, 2004, 9(7), 541-549

Production Method 17

18162-48-6

33036-62-3

89043-32-3

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  overnight, 23 °C

Reference

Cyclopropenium-Activated Cyclodehydration of Diols

Kelly, Brendan D.; Lambert, Tristan H., Organic Letters, 2011, 13(4), 740-743

1-Bromo-4-(t-butyldimethylsilyloxy)butane Raw materials

• tert-butyl(chloro)dimethylsilane
• 4-(Dimethyl-tert-Butylsilyloxy)butan-1-ol
• Porcine Liver Esterase
• 4-((tert-butyldimethylsilyl)oxy)butyl methanesulfonate
• 4-Bromo-1-butanol (contains varying amounts of THF)

1-Bromo-4-(t-butyldimethylsilyloxy)butane Preparation Products

• 1-Bromo-4-(t-butyldimethylsilyloxy)butane (89043-32-3)

• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 3. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 4. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 5. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474

• 96044-45-0(Silane, [(10-bromodecyl)oxy](1,1-dimethylethyl)dimethyl-)
• 380605-59-4((4-Bromo-1,1-dimethylbutoxy)(1,1-dimethylethyl)dimethylsilane)
• 87184-99-4(4-(Dimethyl-tert-Butylsilyloxy)butan-1-ol)
• 568561-96-6(Silane, [(14-bromotetradecyl)oxy](1,1-dimethylethyl)dimethyl-)
• 96045-13-5(Silane, [(8-bromooctyl)oxy](1,1-dimethylethyl)dimethyl-)
• 89031-84-5((3-Bromopropoxy)-tert-butyldimethylsilane)
• 85514-43-8(Silane, [(5-bromopentyl)oxy](1,1-dimethylethyl)dimethyl-)
• 98008-53-8(Silane, [(11-bromoundecyl)oxy](1,1-dimethylethyl)dimethyl-)
• 828934-45-8(Silane, [(5-bromopentyl)oxy]tris(1-methylethyl)-)
• 129368-70-3((6-Bromohexyloxy)-tert-butyldimethylsilane)